To investigate the risk factors of dysphagia after endovascular treatment (EVT) in patients with acute anterior circulation ischemic stroke (AIS).

From January 2020 to March 2022, AIS patients who underwent EVT were eligible for inclusion in the study, and divided retrospectively into dysphagia group and non-dysphagia group according to the postoperative water swallow test in the diagnosis of patients with dysphagia. Univariate and multivariate Logistic regression were used to analyze the related factors of dysphagia.

A total of 197 patients were included, 77 (39.09%) patients developed dysphagia after EVT. There were statistically significant differences in successful reperfusion, symptomatic cerebral hemorrhage and good prognosis at 90 days between the two groups (P < 0.05). Univariate Logistic regression analysis showed that successful reperfusion, symptomatic intracerebral hemorrhage and good prognosis at 90 days were independent risk factors for dysphagia after intravascular therapy (OR = 0.321, 3.743, 2.425; P < 0.05); Multivariate Logistic regression analysis showed that symptomatic cerebral hemorrhage was an independent risk factor for dysphagia after intravascular therapy (OR = 2.889; P < 0.05).

Dysphagia in AIS patients after EVT is markedly related to the transformation of symptomatic hemorrhage, and the occurrence of dysphagia is related to poor clinical prognosis.

To explore the prognostic value of the hypoperfusion intensity ratio (HIR) on 90-day clinical outcome after mechanical thrombectomy (MT) for acute ischemic stroke with large vessel occlusion (AIS-LVO) in elderly (≥80 years) patients.

We retrospectively analyzed the clinical data and imaging materials of the patients with large vessel occlusion, who received mechanical thrombectomy at the First Affiliated Hospital of Nanjing Medical University of China between January 2020 and January 2023. The HIR was defined as the T_max (time to maximum ) > 10 s lesion volume divided by the T_max > 6 s lesion volume. According to the modified Rankin scale (mRS) score 90 d after operation, the patients were divided into favorable prognosis (mRS score ≤2) group and poor prognosis (mRS score 3~6) group. The clinical and imaging data of the 2 groups were compared. The influencing factors of the prognosis 90 d after operation were determined by multivariate logistic regression analysis.

A total of 93 patients were enrolled in this study, including 22 cases in the good prognosis group and 71 cases in the poor prognosis group. Compared with the patients in the poor prognosis group, the patients in the good prognosis group had a smaller core infarction volume, lower HIR and lower baseline National Institute of Health stroke scale ( NIHSS ) score with significant differences (all P < 0.05). Multivariate Logistic regression analysis showed that HIR (OR = 1.424, 95%CI: 1.022~1.984; P = 0.037), collateral scoring (OR = 0.491, 95%CI: 0.263~0.91; P = 0.025) and baseline NIHSS (OR = 1.221, 95%CI: 1.077~1.385; P = 0.002) were independent predictors for prognosis of patients with anterior circulation AIS-LVO 90 d after MT aged ≥80 years.

Low HIR was a predictor for favorable outcome in AIS patients aged ≥80 years.

To investigate the percutaneous transluminal angioplasty (PTA) Safety, efficacy, and clinical efficacy related factor analysis of renal vascular hypertension (RVH) caused by renal artery stenosis in children.

The clinical data from January 2017 to July 2023, a total of 31 cases were included, including 19 cases of Fibromuscular dysplasia(FMD) and 12 cases of Takayasu arteritis (TA). The treatment efficacy and related factors were evaluated by comparing the signs and blood pressure before and after surgery.

A total of 48 PTA sessions were performed, and the follow-up time was from 0.5 to 6.6 years, among which 17 patients were cured, and 7 patients had improved symptoms.24 patients (77.4%) after percutaneous angioplasty, including 16 children with long-term benefit with FMD and 8 children with TA; the ineffective patients had high basal systolic pressure (155 mmHg vs 181 mmHg) and high proportion of vascular non-focal lesions (85.7% vs 16.7%); moreover, all ineffective patients with other symptoms (100%), and the differences were statistically significant. Both univariate and multivariate regression analysis found that focal renal artery lesions were a protective factor for the effect of PTA treatment, and the surgical response rate in patients with focal lesions was 30 times that in patients with non-focal lesions (OR = 30, P = 0.005).

Percutaneous transluminal angioplasty is safe and effective with good long-term follow-up. Patients with focal renal artery lesions had relatively good results after surgery.

To explore the effect of platelet-rich gel (PRG) combined with endovascular angioplasty in promoting the repair of diabetic foot ulcer and angiogenesis, and find a long-term effective treatment for diabetic foot.

A total of 271 patients were eligible for enrollment from 2020 to 2023 in Guangzhou Panyu Central Hospital, who met the enrollment conditions were randomly divided into3 groups. Diabetic foot ulcer in control group was covered with routine disinfection and ordinary adjuvant. In the interventional group, the diabetic foot was treated by endovascular angioplasty, ulcers were covered with ordinary adjuvant. In the PRG + interventional group, PRG was evenly applied to the surface of superficial ulcers, and endovascular angioplasty was used to treat vascular occlusion. Rutherford scale, Wagner scale, foot skin color, skin temperature, ankle-brachial index, ulcer repair area was observed before and after treatment.

A total of 271 patients were included in this study, including 97 cases in the control group, 92 cases in the intervention group, and 82 cases in the PRG + intervention group. There were no significant differences in gender, age, Rutherford grade, Wagner grade, foot skin color, skin temperature, ankle-brachial index, number of vascular occlusion, and ulcer area among the three groups before treatment (P > 0.05). At 1 month and 6 months after treatment, the Rutherford grade and Wagner grade of the patients in PRG + intervention group were significantly reduced, and the skin color and skin temperature of the feet had statistical differences compared with the control group and intervention group (P < 0.05). Especially after 6 months of treatment, the Ankle-brachial index (0.88 ± 0.06), ulcer repair area (4.79 ± 0.32) cm² and ulcer healing rate (68.3%) in PRG + intervention group were significantly different from those in the other two groups (P < 0.05).

PRG combined with endovascular angioplasty has obvious effect in the treatment of diabetic foot ulcer, which can improve the microcirculation in the lower limb ischemic area and promote tissue repair. This method is a new therapeutic model for diabetic foot which is long-term effective, safe and reliable treatment.

To observe the effect of bilateral internal iliac artery balloon occlusion and uterine artery embolization in cesarean section of patients with pernicious placenta previa.

From March 2015 to November 2021, a total of 93 cases of placenta previa who underwent cesarean section assisted by bilateral internal iliac artery balloon occlusion at Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine were enrolled. Prior to the caesarean section, the balloons were prepositioned in the bilateral internal iliac arteries. Once the fetus was successfully delivered, the bilateral balloons were manually dilated by pushing the contrast agent to block the blood flow in the bilateral internal iliac arteries. Subsequently, in cases of uncontrolled hemorrhage during routine placenta dissection, a procedure referred to as "primary embolization" of the bilateral internal iliac and uterine arteries was conducted using gelatin sponge particles. In cases where uterine artery reperfusion occurred or incomplete embolization was observed during internal iliac artery angiography after abdominal wall closure, additional gelatin sponge particles were introduced to enhance the efficacy of the initial "primary embolization". This technique was referred to as "secondary embolization". The patients' intraoperative blood loss, blood transfusion, postoperative hospital stay, hysterectomy and fetal condition were observed.

All 93 cases underwent successful prepositioning of balloons within the bilateral internal iliac arteries prior to cesarean section. Among these cases, ten (10.8%) required dual uterine artery embolizations with gelatin sponge particles during and after the cesarean section, while 83 cases (89.2%) received a single embolization following abdominal closure. All patients successfully underwent cesarean section, and 96 live fetuses were delivered. The mean preoperative hemoglobin concentration was 110 g/L, which decreased to a median of 97 g/L postoperatively. The median intraoperative blood loss and transfusion volume were 1 475 mL and 1 150 mL, respectively. Placenta accreta, placenta increta, and placenta percreta were diagnosed in 30 cases (32.3%), 49 cases (52.7%), and 8 cases (8.6%), respectively. Hysterectomy was performed in eight patients (8.6%).

Cesarean section assisted with bilateral internal iliac artery balloon occlusion is an effective modality for the treatment of pernicious placenta previa. The utility of "secondary embolization" for uterine artery is an effective supplementary way to strengthen the effect of balloons occlusion in the procedure of cesarean section.

To evaluate the clinical efficacy and safety of interventional treatment for delayed hemorrhage after gastric and pancreatic-biliary surgery.

The clinical data of 24 patients with delayed hemorrhage after gastric and pancreatic-biliary surgery treated by the authors' hospital from January 2016 to June 2021 were retrospectively analyzed. The primary endpoints were the technical success and the clinical efficacy rate, and the secondary endpoints were interventional treatment-related complications.

The responsible arteries were identified by angiography in all cases, and the diagnostic positive rate was 100%. Embolization failed in two cases which underwent the second surgery, and the overall technical success rate was 91.7%.15 cases were cured and discharged after treatment. The second interventional treatment was performed in 4 cases with recurrent bleeding, and 3 patients died during hospitalization. The overall clinical efficacy rate was 62.5%. The interventional treatment-related complications included liver ischemia in 5 cases, liver infarction in 2 cases and spleen infarction in 2 cases. The overall complication rate was 37.5%. The cases were divided into the extrahepatic hepatic artery group (n = 11) and the other artery group (n = 13) according to different responsible arteries. There was no significant difference in the technical success rate and the clinical efficacy rate between the two groups (P > 0.05), but the difference of the interventional treatment-related complication rate between the two groups was significant (P = 0.033).

Interventional treatment could be the first choice for delayed hemorrhage after gastric and pancreatic-biliary surgery due to its high diagnostic positive rate, definite therapeutic effect and rare serious complications.

To evaluate the safety and efficacy of transarterial chemoembolization using drug eluting bead (DEB) <150 μm (DCBeadM1^®) combined with sintilimab and bevacizumab in the treatment of unresectable middle/advanced-stage hepatocellular carcinoma (HCC).

Clinical data of 34 patients with unresectable middle/advanced-stage HCC treated with DC Bead M1 combined with sintilimab and bevacizumab in the First Affiliated Hospital of Xinjiang Medical University from April 2021 to October 2022 were retrospectively analyzed. Among them, 29 patients were male and5 female, aged from 33 to 72 years with a median age of 59 years. The informed consents of all patients were obtained and the local ethical committee approval was received. According to the modified response evaluation criteria in solid tumors (mRECIST), the tumor response was evaluated. The adverse events of the combined therapy were observed. The progression-free survival and objective response rate of patients were analyzed.

All patients experienced varying degrees of adverse event ranging from gradeⅠto grade Ⅲafter combination therapy, with postoperative pain being the most significant. No grade Ⅴor fatal adverse events occurred. The follow-up time ranged from 3 to 18 months, with a median of 15 months. The median progression-free survival time were 15 months. The objective response rate at postoperative 1, 3, 6, 12 months were 70.6%, 76.5%, 61.8%, 50.0% and disease control rate were 100%, 94.1%, 82.4%, 67.7%, respectively.

DC Bead M1 combined with sintilimab and bevacizumab shows good safety and tolerance in the treatment of unresectable middle/advanced-stage HCC, which can bring favorable objective response rate and progression-free survival.

To investigate the preparation, physicochemical characterization of iron-copper-based metal-organic frameworks (Fe-Cu MOFs) nanomaterials combined with microwave ablation in treating Hepatocellular Carcinoma.

Fe-Cu MOFs nanomaterials were synthesized by hydrothermal method, their physicochemical characteristics were observed, and the microwave sensitization ability was evaluated by measuring the microwave heating effect of different concentrations (0, 2, 6, 10 mg/mL)in vitro. In addition, biocompatibility was evaluated at the cellular level, and the inhibitory effect of combined therapy with microwave ablation on cell proliferation was explored. Subsequently, a subcutaneous tumor model in H22 Hepatocellular Carcinoma mice was established to evaluate the inhibitory effect of Fe-Cu MOFs combined with MW on tumor growth.

Fe-Cu MOFs nanomaterials with a faceted structure and a particle size of (182.28 ± 0.79) nm was successfully synthesized. The heating effect under microwave irradiation increased with the duration and concentration of the nanomaterials. Fe-Cu MOFs combined with microwave irradiation notably suppressed tumor cell proliferation. In vivo studies showed that mice treated with Fe-Cu MOFs and microwaves exhibited higher tumor site temperatures and significantly reduced tumor volumes compared to microwave-only treatment.

Fe-Cu MOFs nanomaterials have good microwave sensitization properties, which can effectively improve the therapeutic effect of microwave ablation in Hepatocellular Carcinoma.

To evaluate the systematic evaluation of the safety and efficacy of catheter directed thrombolysis in patients with lower extremity deep venous thrombosis.

In September 2021, systematic reviews/meta-analyses were retrieved from CNKI, WanFang Medical Platform, Web of Science, EBSCO, Cochrane Library, PubMed, Databases@OVID and other databases. The search strategy is a combination of Chinese/English free words and subject words and the Zotero software was used to manage references. Two researchers used AMSTAR2 and GRADE respectively to evaluate the quality of literature and outcome indicators.

A total of 8 RCT/NRSI systematic evaluations were included. The evaluation results of AMSTAR2 showed that 1 article was of high quality, 1 article was of intermediate quality,3 articles were of low quality and 3 articles were of extremely low quality. GRADE evaluation results showed 0 advanced evidences, accounting for 0%; 7 pieces of intermediate evidence, accounting for 23.33%,16 pieces of low-level evidence, accounting for 53.33%, and 7 pieces of extremely low-level evidence, accounting for 23.33%.

The infusion method, time and dose of thrombolytic drugs are the influencing factors of bleeding related safety. The main evidence of effectiveness was the rate of venous patency and the incidence of post-thrombotic syndrome. However, the relevant evidence is limited, which still needs further study.

To explore the effect of gradient compression stockings (GCS) combined with intermittent pneumatic compression (IPC) in the prevention of lower extremity deep vein thrombosis (LEDVT) in elderly patients with corona virus disease 2019 (COVID-19).

Sixty elderly patients with COVID-19 in our hospital from November 2022 to January 2023 were selected and randomly divided into observation group and control group through an online random number generator, with 30 cases in each group. The control group was given routine preventive intervention, while the observation group was given GCS combined with IPC inflation and compression intervention on the basis of routine intervention. The activated partial thromboplastin time (APTT), thrombin time (TT), bilateral femoral vein blood flow velocity, serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), patient satisfaction, occurrence rate of lower limb edema, and incidence rate of LEDVT were compared between the two groups.

There was no statistically significant difference in general data between the two groups of patients (P > 0.05). APTT, TT and bilateral femoral vein blood flow velocity in observation group were higher than those in control group, with statistically significant difference (P < 0.05). The incidence of lower limb swelling and LEDVT, TNF-α and IL-6 levels observation group were lower than those in control group (P < 0.05). The satisfaction of patients in observation group was significantly higher than that in control group (P < 0.05).

GCS combined with IPC can improve the coagulation function of elderly patients with COVID-19, reduce inflammatory reaction, increase the blood flow velocity of bilateral femoral veins, and significantly reduce the incidence of LEDVT.

To investigate and analyze the cognition level of VTE and its influencing factors of the elderly in the communities, so as to provide scientific support for developing and implementing VTE prevention strategies among the elderly in the communities.

A total of 910 community elderly people (age≥60 years ) from 5 regions in Hunan province were selected by stratified random sampling method. The general information questionnaire, the VTE cognition level questionnaire, the training willingness questionnaire and the Padua Thrombosis Risk Assessment Form were used to conduct the investigation. Multiple linear regression was used to analyze the influencing factors of VTE cognitive level.

Among the elderly in communities, 7.96% were at high-risk of VTE, 16.59% were aware of VTE, and 64.38% were willing to receive training. There were statistically significant differences in cognitive level scores among study subjects with different age, educational level, VTE history, training willingness, and body mass index (BMI) (P < 0.05). The results of multiple linear regression analysis showed that educational level, BMI, and training willingness were the main influencing factors of VTE cognitive level (P < 0.05).

The proportion of high-risk VTE population among the elderly in communities in Hunan Province was high, while the cognitive level was low, and they had a strong willingness to receive training. The elderly with low educational level or high BMI have a lower level of VTE cognition. The ones with strong training willingness have a higher level of VTE cognition. It is urgent to take a series of measures to improve cognitive level, and developing early prevention of VTE among the elderly in the communities.

To explore the application of KTH integrated intervention mode in nursing care of patients with liver cancer undergoing continuous hepatic artery infusion chemotherapy (HAIC).

Clinical data of 100 liver cancer patients undergoing HAIC in the Department of Interventional Therapy from January 2022 to March 2023 were prospectively collected. They were randomly assigned to either the observation group or the control group. The control group received routine nursing care, while the observation group received the KTH Integrated Intervention Model in addition to routine care. The postoperative self-efficacy and quality of life were compared between the two groups.

Before intervention, there was no significant difference in general self-efficacy scale (GSES) scores and quality of life scores between the two groups (P > 0.05). After intervention, the GSES score of the observation group was higher than that of the control group, with statistically significant difference (P < 0.05). The quality of life scores of the observation group and the control group were higher than those before intervention, and the observation group was higher than that of the control group, with statistically significant differences (P < 0.05).

The use of the KTH integrated intervention model in patients with hepatocellular cancer during continuous perfusion chemotherapy can enhance the self-efficacy of patients after nursing care and improve their quality of life.