To evaluate the efficacy and safety of transcatheter interventional therapy combined with targeted and immune therapy versus targeted and immune therapy alone in the treatment of unresectable hepatocellular carcinoma.

A systematic review and meta-analysis conforming to PRISMA guidelines were conducted by searching the Cochrane Library, PubMed, and Embase databases up to January 2026. Relevant literature was collected, and two researchers conducted literature screening and quality assessment according to the inclusion and exclusion criteria. The meta-analysis was performed using RevMan 5.3.

A total of 18 studies were included, involving 3 168 patients, with 1 794 in the combination therapy group and 1,374 in the single targeted-immunotherapy group. The combination therapy group showed higher complete response rate (OR=2.69, 95% CI: 1.45–4.99), objective response rate (OR=2.75, 95% CI: 2.35–3.22), and disease control rate (OR=2.61, 95% CI: 1.78–3.83), as well as longer progression-free survival (HR=0.56, 95% CI: 0.48–0.65) and overall survival (HR=0.5, 95% CI: 0.44–0.57). Regarding safety, the combination therapy group had significantly higher rates of elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST), hyperbilirubinemia, nausea/vomiting, and abdominal pain.

The findings suggest that the transcatheter interventional therapy combined with targeted immunotherapy can improve the local control rate and long-term survival rate of unresectable HCC.

To investigate the efficacy and safety of transcatheter arterial chemoembolization combined with hepatic arterial infusion chemotherapy in the treatment of unresectable hepatocellular carcinoma.

Search for articles published in PubMed, Embase, Web of Science, CNKI, Wanfang and VIP databases from January 1, 2015 to December 31, 2025 that discuss the treatment of unresectable hepatocellular carcinoma with TACE combined with HAIC. Extract relevant data such as objective response rate, disease control rate, overall survival, progression-free survival, and adverse events, and conduct a Meta-analysis using Review Manager 5.4 software.

A total of 7 articles were included. The meta-analysis results showed that the TACE combined with HAIC group had better outcomes in terms of ORR、DCR、OS、PFS compared to the TACE group. For any grade adverse events, The risk of adverse reactions in the TACE combined with HAIC group was higher than that in the TACE group. For grade 3-4 adverse events, The risk of pain and elevated alanine aminotransferase in the TACE combined with HAIC group was higher than that in the TACE group.

Based on the current evidence, the combination of TACE and HAIC may improve the tumor response rate and prolong survival time, its safety remains to be investigated. However, further confirmation is required from prospective, multicenter, randomized controlled trials.

Coronary artery disease (CAD) is a major global public health concern, and interventional therapy has become an important approach for its diagnosis and treatment. In recent years, artificial intelligence (AI) has increasingly been applied to the integrated analysis of coronary multimodal imaging and clinical data. AI can extract and analyze multimodal imaging features, assisting physicians in lesion identification, plaque analysis, and functional assessment. It can also integrate perioperative clinical information for risk stratification and prognostic prediction. AI may be applied throughout the entire process of interventional treatment for CAD, including preoperative decision-making, intraoperative guidance, and postoperative management, thereby providing support for optimizing interventional strategies and risk stratification. This article reviews the research progress of AI in interventional treatment and prognostic evaluation of CAD, with the aim of providing a reference for precision interventional therapy and intelligent management of CAD.

Superior vena cava syndrome (SVCS) comprises the clinical manifestations of partial or complete obstruction of the superior vena cava and its major tributaries. Standard care is based on chemoradiotherapy; however, minimally invasive, highly effective endovascular interventions have become the preferred option for patients with critical compression. This review integrates current evidence on malignant SVCS, mapping its clinical presentation, diagnostic work-up and therapeutic landscape, and critically appraises the efficacy and oncological impact of contemporary endovascular techniques.

To evaluate the efficacy and safety of iodine-125 (¹²⁵I) seed strand combined with biliary self-expandable metallic stent (SEMS) versus SEMS alone in unresectable Bismuth Ⅲ–Ⅲ hilar cholangiocarcinoma (HCCA).

This retrospective study included 60 patients with unresectable Bismuth type III/IV HCCA treated at First Affiliated Hospital of Xinjiang Medical University from June 2019 to January 2025. Thirty-two patients received ¹²⁵I seed strand plus biliary SEMS (combined group) and 28 received SEMS alone (control group). Postoperative liver function, adverse events, stent patency, and overall survival were compared between groups.

Technical success was 100% in both groups, and jaundice was clearly relieved postprocedure. Improvements in liver function tests and overall adverse event rates did not differ significantly between groups (P>0.05). Median overall survival was longer in the combined group (9.00 months; 95% CI: 6.25–11.75) than in the control group (6.00 months; 95% CI: 5.17–6.83; P<0.05). Median stent patency was also longer in the combined group (7.00 months; 95% CI: 3.67–10.33) versus the control group (5.00 months; 95% CI: 3.70–6.30; P<0.05).

Placement of ¹²⁵I seed strand combined with biliary SEMS is safe and feasible for unresectable Bismuth III–IV HCCA. It effectively relieves biliary obstruction and prolongs stent patency and patient survival.

To investigate the relationship between C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and puncture-related lower extremity arterial thrombosis following abdominal aortic balloon occlusion combined with caesarean section in patients with placenta accreta spectrum (PAS).

A retrospective analysis was conducted on baseline data, serological indicators, and perioperative indicators of PAS patients treated at our hospital. Univariate and multivariate logistic regression analyses were performed to identify relevant factors. Receiver operating characteristic (ROC) curves were plotted to evaluate predictive value.

The levels of CRP, NLR, D-dimer, and the amount of red blood cells transfused intraoperatively in the thrombus group differed significantly from those in the non-thrombus group (P < 0.05). Logistic regression analysis indicated that CRP, NLR, and D-dimer were associated with puncture-related lower extremity arterial thrombosis following balloon occlusion and cesarean section in PAS patients, with AUC values of 0.752, 0.710, and 0.703, respectively.

CRP and NLR were associated with early puncture-related lower extremity arterial thrombosis following abdominal aortic balloon occlusion and cesarean section in PAS patients.

To compare post-procedural events (procedure-related complications plus events of uncertain attribution) and outcomes between splenic artery aneurysm (SAA) sac embolization and combined embolization (various combinations of outflow tract, sac, and inflow tract).

A retrospective study of 53 SAA patients (June 2022–June 2024) was conducted. Patients were divided into sac embolization group (n=25) and combined embolization group (n=28). Baseline data, post-procedural events, and outcomes were compared.

The sac embolization group had significantly lower overall post-procedural events at 3 months and 1 year (P<0.05). No significant difference was found in procedure-related complications (dissection, pancreatitis, splenic infarction) between groups (P>0.05). At 3-month follow-up, no recanalization or rupture occurred in either group. At 1-year follow-up, no abnormalities were seen in the sac embolization group, while one case of partial coil migration occurred in the combined group (P>0.05).

Both interventional techniques are safe and effective, with no significant difference in procedure-related complication risk. The difference in overall post-procedural events is mainly attributed to non-procedure-specific events (e.g., deep vein thrombosis, ileus). Technique selection should be individualized based on anatomical conditions

To evaluate the predictive value of contrast injection pressure during hysterosalpingography (HSG) for non-in vitro fertilization (IVF)-assisted pregnancy.

This study enrolled 318 patients with tubal infertility who underwent HSG at Women's Hospital of Nanjing Medical University between January 2024 and February 2025. Injection pressure at contrast spillage from the fimbrial end during HSG was recorded. Patients were followed for 1 year. Among them, 267 reached the endpoint and 243 completed follow-up. The association between injection pressure and pregnancy was analyzed.

The competing risk model showed that injection pressure had a significant negative effect on non-IVF pregnancy (P=0.001). ROC curve analysis showed that the area under the curve of injection pressure for predicting non-IVF pregnancy was 0.715(95% CI: 0.651-0.778, P<0.001), and the exploratory threshold was 45 kPa. When divided into low-pressure group (≤45 kPa, n=141) and high-pressure group (>45 kPa, n=69) according to 45 kPa, the non-IVF pregnancy rate in the high-pressure group was significantly lower than that in the low-pressure group (P=0.004).

Injection pressure during HSG is inversely associated with pregnancy. The exploratory threshold of 45 kPa may serve as a potential reference for generating clinical hypotheses regarding risk stratification, providing direction for individualized precision medicine. However, validation through multicenter prospective studies is required.

To investigate the influencing factors of hemorrhagic transformation (HT) in patients with acute anterior circulation ischemic stroke after intravenous thrombolysis with alteplase combined with bridging mechanical thrombectomy.

Clinical data of 177 patients with acute anterior circulation ischemic stroke undergoing bridging therapy from November 2022 to July 2024 were retrospectively analyzed. Patients were divided into HT group (n=93) and non-HT group (n=84) according to the presence or absence of postoperative hemorrhage. Univariate and multivariate Logistic regression analyses were performed to identify independent risk factors for HT.

The incidence of HT was 52.5% among 177 patients. Multivariate analysis showed that higher admission National Institutes of Health Stroke Scale (NIHSS) score and multiple thrombectomy passes were independent risk factors for postoperative HT (P<0.05). For prognosis, the 90-day favorable prognosis rate (modified Rankin Scale score ≤2) was significantly lower in HT group than in non-HT group (43.0% vs. 58.3%, P<0.05).

High baseline NIHSS score on admission and multiple thrombectomy passes are independent risk factors for HT in acute anterior circulation ischemic stroke patients after bridging therapy.

To explore the influencing factors of poor prognosis after mechanical thrombectomy for anterior circulation stroke and to construct prediction model.

Patients with anterior circulation ALVOS who underwent mechanical thrombectomy from January 2020 to December 2024 were divided into good prognosis group and poor prognosis group based on the 90-day postoperative prognosis. The baseline data, surgical conditions, and perioperative complications were analyzed. A clinical prediction model was constructed and its accuracy and efficacy were verified.

A total of 528 patients were enrolled. Logistic regression analysis indicated that age, time of consultation, D-dimer, NIHSS score, number of thrombectomy, symptomatic intracranial hemorrhage, and successful reperfusion were independent influencing factors for poor prognosis (P< 0.05). Based on the above factors, a prediction model was constructed, and the calibration curve and decision curve showed that the model had good efficacy.

The model constructed for anterior circulation ALVOS based on age, time of consultation, D-dimer, baseline NIHSS score, number of thrombectomy, successful reperfusion, and symptomatic intracranial hemorrhage has good predictive efficacy for poor prognosis.

To compare the efficacy, complications, and postoperative discomfort of totally implantable access ports (TIAP) implanted via the subclavian vein (SCV) versus the internal jugular vein (IJV) in cancer patients, and to analyze factors associated with catheter malposition.

A total of 724 cancer patients were prospectively enrolled and non-randomly assigned to the subclavian vein (SCV) group (n=224) or the internal jugular vein (IJV) group (n=500) according to the venous access approach. Blind puncture success rate, operative time, complications, and postoperative discomfort grade scores were compared between the two groups. Firth-corrected logistic regression was used to analyze factors associated with catheter malposition.

The IJV group had a higher blind puncture success rate (P<0.001) but longer operative time (P<0.001) than the SCV group. The SCV group showed a higher incidence of catheter malposition (P<0.001) but better postoperative discomfort scores (P<0.05). Firth regression indicated that the IJV approach was associated with a lower risk of malposition (P=0.005); older age (P=0.027) and obesity (BMI≥28, P=0.038) were also associated factors.

The IJV approach offers a higher blind puncture success rate and lower malposition risk, while the SCV approach is associated with shorter operative time and milder patient-reported discomfort. Clinical selection should be individualized.

Investigating the impact of the retrieval hook orientation of inferior vena cava filters implanted via the femoral vein and the choice of femoral vein approach during retrieval on the number of capture attempts.

26 patients with lower limb deep vein thrombosis with or without pulmonary embolism were treated by inserting an inferior vena cava filter through the femoral vein. After anticoagulation and thrombectomy, the inferior vena cava filter was removed. Among them, there were 9 cases of retrieving filters through the contralateral femoral vein approach with the opening direction of the retrieval hook, and 17 cases through the ipsilateral approach. Following the removal of the filter, the patients underwent oral anticoagulant therapy for a duration of six months and were subjected to regular follow-up examinations.

26 patients successfully removed the filters. Nine cases were retrieved from the contralateral femoral vein via the retrieval hook opening direction, with 7-12 captures, while 17 cases were retrieved from the ipsilateral approach, with 1-4 captures. The difference was statistically significant (P<0.001).

When retrieving a filter via the femoral venous approach, selecting the same side as the opening direction of the femoral venous access can significantly reduce the number of captures, making. It can serve as a reference for selecting the approach when retrieving the biconical inferior vena cava filter via the femoral vein.

To develop the "Expert Consensus on Nursing Standards for Uterine Fibroid Arterial Embolization Intervention (2026 Edition)" (hereinafter referred to as the "Consensus"), aiming to standardize perioperative nursing care for patients undergoing transarterial embolization for uterine fibroids. Through systematic literature retrieval, based on domestic and international relevant medical and nursing guidelines, expert consensus, combined with evidence-based evidence and clinical practice experience, a draft consensus was formed. Fifty-five experts and scholars in interventional vascular medicine and related fields were invited to repeatedly revise the draft, continuously improving it to form the final consensus. The Consensus covers preoperative specialized nursing assessment for uterine fibroids, risk factor interventions, patient-controlled analgesia management, preoperative preparation, postoperative care, prevention and nursing strategies for complications, and pre-discharge health education.

To investigate the effects of Mindfulness-Based Stress Reduction (MBSR) therapy under a mobile health service model on the psychological resilience and self-efficacy of caregivers with home-bound disabled elders undergoing percutaneous transhepatic cholangial drainage recovery (PTCD).

The study enrolled 110 primary caregivers of disabled elders who underwent PTCD between March 2024 and May 2025 within a designated district of Shanghai. Participants were randomly assigned using a digital random table to either an intervention group or a control group (n=55). The experimental group received a self-developed mobile nursing information support mini-program equipped with "MBSR training," while the control group received routine postoperative psychological care. Both groups were assessed before and after intervention using the Psychological Resilience Scale, Self-Efficacy Scale, and Depression-Anxiety-Stress Scale.

Following the intervention, the experimental group demonstrated significantly higher total scores on psychological resilience and self-efficacy compared to both the control group and baseline levels (P<0.05). In contrast, the control group showed only a statistically significant difference in the strength dimension of the psychological resilience scale compared to baseline (P<0.05), while other dimensions were not statistically significant (P>0.05). Among the three dimensions of negative emotions (depression, anxiety, and stress), the experimental group scored significantly lower than the control group only in the stress dimension (P<0.05).No statistically significant differences were observed in the other dimensions (P>0.05).

The mobile nursing information support mini-program equipped with “MBSR training” can enhance the psychological resilience and self-efficacy among caregivers of disabled elders undergoing PTCD, demonstrating significant potential for broad social application.

To explore the factors influencing clinical nurses' participation in case writing and the corresponding rectification strategies.

A questionnaire survey was conducted via WeChat mini-program in June 2025, targeting 1 461 clinical nurses nationwide. Data on their participation in case writing was collected, and logistic regression analysis was employed to assess the influencing factors of case writing participation frequency.

The frequency of case writing among the included clinical nurses was positively correlated with their cognitive level, training needs, and attitude scores (P<0.05). Logistic regression analysis revealed that working in a public hospital, having a higher cognitive level, and a higher training needs score were facilitating factors for clinical nurses to participate in case writing frequently; whereas being a charge nurse and working in an emergency department or pediatric department were hindering factors (P<0.05).

The nature of the work unit, cognitive level of case writing, training needs, professional title, and department are independent influencing factors for clinical nurses' participation in case writing. The study proposes to construct a three-in-one intervention pathway of "structured training system-organizational support mechanism-job adaptability optimization" to systematically enhance the participation and quality of clinical nurses' case writing.

Inferior pancreaticoduodenal artery aneurysms (IPDAA) are rare visceral aneurysms with diverse clinical presentations. We report the case of a 59-year-old man who initially presented with symptoms of intestinal obstruction, with imaging findings suggestive of duodenal stenosis. A subsequent progressive decrease in hemoglobin level prompted further evaluation with contrast-enhanced computed tomography, which revealed multiple ruptured IPDAAs associated with an abdominal hematoma compressing the duodenum and resulting in mechanical obstruction. The aneurysms were successfully treated with transcatheter arterial embolization. After the procedure, the patient's obstructive symptoms resolved, and follow-up imaging demonstrated gradual hematoma absorption and resolution of duodenal edema. This case highlights that IPDAA may present atypically as duodenal obstruction.

This case report describes the diagnosis and treatment of a 6-year-old child with hyperimmunoglobulin E syndrome (HIES) complicated by pulmonary artery pseudoaneurysm (PAPA). The child presented with hemoptysis, and chest computed tomography angiography (CTA) confirmed the diagnosis of PAPA. During interventional embolization, neither systemic arteriography nor main pulmonary artery angiography revealed the aneurysm; however, superselective angiography of the left lower pulmonary artery branch via a microcatheter successfully visualized the aneurysmal sac, which was then embolized with coils. Hemoptysis ceased after the procedure. The child underwent unrelated hematopoietic stem cell transplantation three months later and has remained free of hemoptysis during 18 months of follow-up, with imaging showing stable coil position and no recurrence of PAPA. This case highlights that in children with HIES presenting with hemoptysis, PAPA should be highly suspected. Interventional treatment requires combined systemic and multi-level pulmonary artery angiography for accurate localization, and active management of the underlying disease is crucial for preventing recurrence.