切换至 "中华医学电子期刊资源库"

中华介入放射学电子杂志 ›› 2025, Vol. 13 ›› Issue (02) : 152 -163. doi: 10.3877/cma.j.issn.2095-5782.2025.02.009

基础研究

经颈静脉肝内门体分流术与肝性脑病相关研究的文献计量学分析
王聪1, 姜华1, 彭文凯1, 汪祖鑫1, 李松蔚1,()   
  1. 1. 650101 云南昆明,昆明医科大学第二附属医院肿瘤多学科诊疗中心放射介入组
  • 收稿日期:2024-07-24 出版日期:2025-05-25
  • 通信作者: 李松蔚
  • 基金资助:
    昆明医科大学第二附属医院院内临床研究项目(ynIIT2022009)

Bibliometric analysis of studies related to TIPS and hepatic encephalopathy

Cong Wang1, Hua Jiang1, Wenkai Peng1, Zuxin Wang1, Songwei Li1,()   

  1. 1. Platform for Interventional Radiology, Multidisciplinary Center for Diagnosis and Treatment of Cancer, The Second Affiliated Hospital of Kunming Medical University, Yunnan Kunming 650101, China
  • Received:2024-07-24 Published:2025-05-25
  • Corresponding author: Songwei Li
引用本文:

王聪, 姜华, 彭文凯, 汪祖鑫, 李松蔚. 经颈静脉肝内门体分流术与肝性脑病相关研究的文献计量学分析[J/OL]. 中华介入放射学电子杂志, 2025, 13(02): 152-163.

Cong Wang, Hua Jiang, Wenkai Peng, Zuxin Wang, Songwei Li. Bibliometric analysis of studies related to TIPS and hepatic encephalopathy[J/OL]. Chinese Journal of Interventional Radiology(Electronic Edition), 2025, 13(02): 152-163.

目的

通过文献计量学分析探讨经颈静脉肝内门体分流术(transjugular intrahepatic portosystemic shunt, TIPS)与肝性脑病研究热点和未来趋势,为该领域学术研究提供借鉴。

方法

检索Web of science 数据库2014 年至2023 年间TIPS 与肝性脑病相关文献,运用VOS viewer、Bibliometrix及Citespase 软件进行分析。

结果

检索后共纳入文献454 篇,近10 年发文量总体呈上升趋势。中国发文量最多,其中中国第四军医大学是最高产的研究机构,中国的韩国宏、熊斌、王磊是发文最多的作者。危险因素分析、肌少症、营养不良是目前该领域的研究热点。

结论

中国在TIPS 与肝性脑病研究领域的贡献突出,但高质量文献数量有待提高。未来应重视TIPS 术后肝性脑病危险因素分析和预测模型构建相关研究,特别是肌少症和营养不良作为当前研究热点,值得进一步关注。

Objective

To explore the hotspots and future trends of research related to TIPS and hepatic encephalopathy through bibliometrics for academic research in this field.

Methods

The Web of Science database was searched for literature related to TIPS and hepatic encephalopathy published between 2014 and 2023, and the data were counted and analyzed using VOSviewer, Bibliometrix, and CiteSpace software.

Results

A total of 454 articles were included in the search, and there was a general upward trend in the number of articles published in the past 10 years.China had the highest number of publications; the Fourth Military Medical University of China was the most prolific institution, and Guohong Han, Bin Xiong,and Lei Wang from China were the authors with the most publications.Risk factor analysis, myasthenia gravis, and dystrophy are the current research hotspots in this field.

Conclusion

China's contribution to the research field of TIPS and hepatic encephalopathy is outstanding, but the number of high-quality studies needs to be improved.In the future, attention should be paid to studies related to risk factors and predictive models of hepatic encephalopathy after TIPS, especially myasthenia gravis and malnutrition, as the current research hotspots in this field deserve further attention.

图1 TIPS 与HE 相关研究文献年发文量分布情况 注:TIPS:经颈静脉肝内门体分流术;HE:肝性脑病。
表1 WOS 数据库TIPS 与HE 相关研究文献发文量、平均被引次数、总链接强度前12 位的国家
图2 国家/地区间合作情况网络
图3 国家/地区间合作情况-时间叠加网络
表2 TIPS 与HE 研究领域相关文献发文量、总被引次数、总关联强度前15 位的科研机构
排名 机构名称 发文量 机构 总被引次数 机构名称 总关联强度
1 第四军医大学 (中国) 24 第四军医大学 (中国) 970 第四军医大学 (中国) 386
2 首都医科大学 (中国) 21 波恩大学 (德国) 522 波恩大学 (德国) 170
3 华中科技大学 (中国) 18 罗马大学 (意大利) 391 罗马大学 (意大利) 140
4 四川大学 (中国) 15 西安交通大学 (中国) 235 华中科技大学(中国) 132
5 华中科技大学同济医学院协和医院(中国) 15 巴塞罗那大学 (西班牙) 230 四川大学 (中国) 127
6 罗马大学 (意大利) 14 四川大学 (中国) 190 首都医科大学 (中国) 118
7 南方医科大学 (中国) 12 首都医科大学 (中国) 181 西安交通大学 (中国) 116
8 南京大学 (中国) 12 巴塞罗那临床医疗中心(西班牙) 181 南方医科大学 (中国) 111
9 加州大学洛杉矶分校 (美国) 9 南京大学 (中国) 159 华中科技大学同济医学院协和医院 (中国) 108
10 昆明医科大学 (中国) 9 克利夫兰诊所医学中心 (美国) 158 摩德纳和雷焦的艾米利亚大学(意大利) 101
11 波恩大学(中国) 8 南方医科大学(中国) 144 南京大学(中国) 99
12 中山纪念医院 (中国) 8 山东大学(中国) 139 加州大学洛杉矶分校(美国) 97
13 伊利诺伊大学(美国) 8 昆明医科大学(中国) 137 中山纪念医院 (中国) 94
14 山东大学(中国) 8 加州大学洛杉矶分校(美国) 134 昆明医科大学(中国) 92
15 巴塞罗那大学(西班牙) 8 索邦大学(法国) 128 克利夫兰诊所医学中心(美国) 86
图4 机构间合作情况网络
图5 机构间合作情况-时间叠加网络
表3 TIPS 与HE 研究领域发文量、被引频次前15 位的期刊
表4 TIPS 与HE 研究领域发文量、被引次数、平均被引次数排名前10 的作者
图6 活跃作者合作情况网络
图7 活跃作者合作情况-时间叠加网络
表5 TIPS 与HE 研究领域总被引次数排名前10 的文献信息
排名 作者 发表时间 文章题目 期刊 类型 总被引次数 年平均被引次数
1 sauerbruch,et al[10] 2015 Prevention of rebleeding from esophageal varices in patients with cirrhosis receiving small-diameter stents versus hemodynamically controlled medical therapy gastroenterology 论著 159 17.7
2 holster,et al[11] 2016 Covered transjugular intrahepatic portosystemic shunt versus endoscopic therapy plus B-blocker for prevention of variceal rebleeding hepatology 论著 133 16.6
3 perarnau,et al[12] 2014 Covered vs uncovered stents for transjugular intrahepatic portosystemic shunt a randomized controlled trial journal of hepatology 论著 130 13.0
4 nardelli,et al[13] 2017 Sarcopenia is risk factor for development of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt placement clinical gastroenterology and hepatology 论著 124 17.7
5 Hernandez-Gea,et al[14] 2019 Preemptive-TIPS Improves Outcome in High-Risk Variceal Bleeding: An Observational Study Hepatology 论著 119 23.8
6 吕勇, 等[15] 2019 Early tips with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis: arandomised controlled trial lancet gastroenterology & hepatology 论著 118 23.6
7 王秋和, 等[16] 2017 Eight milimetre covered tips does not compromise shunt function but reduces hepatic encephalopathy in preventing variceal rebleeding journal of hepatology 论著 109 15.6
8 吕勇, 等[17] 2018 Covered tips versus endoscopic band ligation plus propranolol for the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis: a randomised controlled trial gut 论著 104 17.3
9 praktikrjo, et al[18] 2018 Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis hepatology 论著 104 17.3
10 柏明, 等[19] 2014 Tips improves liver transplantation-free survival in cirrhotic patients with refractory ascites: an updated meta-analysis world journal of gastroenterology 综述 93 9.3
图8 TIPS 与HE 研究领域关键词共现网络 注:TIPS: 经颈静脉肝内门体分流术; HE:肝性脑病。
图9 TIPS 与HE 研究领域关键词共现-时间叠加网络 注:TIPS: 经颈静脉肝内门体分流术; HE:肝性脑病。
图10 TIPS 与HE 研究领域热点研究主题变化趋势图谱 注:TIPS: 经颈静脉肝内门体分流术; HE:肝性脑病。
图11 TIPS 与HE 研究领域关键词突现图谱 注:TIPS:经颈静脉肝内门体分流术;HE:肝性脑病。
[1]
Zhao Y, Wang Y, Xu J.Predictive accuracy comparison of prognostic scoring systems for survival in patients undergoing tips placement: a systematic review and meta-analysis [J].Acad Radiol, 2024, 31(9):3688-3710.
[2]
Fonio P, Discalzi A, Calandri M, et al.Incidence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt (TIPS) according to its severity and temporal grading classification [J].Radiol Med, 2017, 122(9): 713-721.
[3]
Rose CF, Amodio P, Bajaj JS, et al.Hepatic encephalopathy:Novel insights into classification, pathophysiology and therapy[J].J Hepatol, 2020, 73(6): 1526-1547.
[4]
Rudler M, Weiss N, Bouzbib C, et al.Diagnosis and management of hepatic encephalopathy [J].Clin Liver Dis, 2021, 25(2): 393-417.
[5]
Santisteban-Espejo A, Moral-Munoz JA, Campos A, et al.The challenge of discovering the threshold concepts of medical research areas: a bibliometrics-based approach [J].Med Hypotheses, 2020, 143: 110099.
[6]
Zhang J, Luo Z, Zhang R, et al.The transition of surgical simulation training and its learning curve: a bibliometric analysis from 2000 to 2023 [J].Int J Surg, 2024,110(6):3326-3337.
[7]
Li S, Huang Z, Zhu T, et al.Trends and hotspots in acupuncture treatment of rat models of stroke: a bibliometric analysis from 2004 to 2023 [J].Front Neurosci, 2024, 18: 1383283.
[8]
Cao W, Jin M, Zhou W, et al.Forefronts and hotspots evolution of the nanomaterial application in anti-tumor immunotherapy:a scientometric analysis [J].J Nanobiotechnology, 2024, 22(1):30.
[9]
Chen Y, Lin M, Zhuang D.Wastewater treatment and emerging contaminants: Bibliometric analysis [J].Chemosphere, 2022,297: 133932.
[10]
Sauerbruch T, Mengel M, Dollinger M, et al.Prevention of rebleeding from esophageal varices in patients with cirrhosis receiving small-diameter stents versus hemodynamically controlled medical therapy [J].Gastroenterology, 2015, 149(3):660-668.e1.
[11]
Holster IL, Tjwa ET, Moelker A,· et al.Covered transjugular intrahepatic portosystemic shunt versus endoscopic therapy +β-blocker for prevention of variceal rebleeding [J].Hepatology,2016, 63(2): 581-589.
[12]
Perarnau JM, Le Gouge A, Nicolas C, et al.Covered vs.uncovered stents for transjugular intrahepatic portosystemic shunt: a randomized controlled trial [J].J Hepatol, 2014, 60(5):962-968.
[13]
Nardelli S, Lattanzi B, Torrisi S, et al.Sarcopenia is risk factor for development of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt placement [J].Clin Gastroenterol Hepatol, 2017, 15(6): 934-946.
[14]
Hernández-Gea V, Procopet B, Giráldez Á, et al.Preemptive-TIPS improves outcome in high-risk variceal bleeding: an observational study [J].Hepatology, 2019, 69(1): 282-293.
[15]
Lv Y, Yang Z, Liu L, et al.Early TIPS with covered stents versus standard treatment for acute variceal bleeding in patients with advanced cirrhosis: a randomised controlled trial [J].Lancet Gastroenterol Hepatol, 2019, 4(8): 587-598.
[16]
Wang Q, Lv Y, Bai M, et al.Eight millimetre covered TIPS does not compromise shunt function but reduces hepatic encephalopathy in preventing variceal rebleeding [J].J Hepatol,2017, 67(3): 508-516.
[17]
Lv Y, Qi X, He C, et al.Covered TIPS versus endoscopic band ligation plus propranolol for the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis: a randomised controlled trial [J].Gut, 2018, 67(12): 2156-2168.
[18]
Praktiknjo M, Book M, Luetkens J, et al.Fat-free muscle mass in magnetic resonance imaging predicts acute-on-chronic liver failure and survival in decompensated cirrhosis [J].Hepatology,2018, 67(3): 1014-1026.
[19]
Bai M, Qi XS, Yang ZP, et al.TIPS improves liver transplantation-free survival in cirrhotic patients with refractory ascites: an updated meta-analysis [J].World J Gastroenterol,2014, 20(10): 2704-2714.
[20]
Ferral H, Gomez-Reyes E, Fimmel CJ.Post-transjugular intrahepatic portosystemic shunt follow-up and management in the VIATORR era [J].Tech Vasc Interv Radiol, 2016, 19(1): 82-88.
[21]
Triantafyllou T, Aggarwal P, Gupta E, et al.Polytetrafluoroethylenecovered stent graft versus bare stent in transjugular intrahepatic portosystemic shunt: systematic review and meta-analysis [J].J Laparoendosc Adv Surg Tech A, 2018, 28(7): 867-879.
[22]
Zhu P, Dong S, Sun P, et al.Expanded polytetrafluoroethylene(ePTFE)-covered stents versus bare stents for transjugular intrahepatic portosystemic shunt in people with liver cirrhosis [J].Cochrane Database Syst Rev, 2023, 8(8): Cd012358.
[23]
Berengy MS, Abd El-Hamid Hassan EM, Ibrahim AH, et al.Safety and efficacy of transjugular intrahepatic portosystemic shunts vs endoscopic band ligation plus propranolol in patients with cirrhosis with portal vein thrombosis: a systematic review and meta-analysis [J].J Gastrointest Surg, 2024, 28(3): 316-326.
[24]
黄俊, 江晶晶, 邵慧娟, 等.1990—2019年我国酒精性肝病的疾病负担分析 [J].现代预防医学, 2023, 50(20): 3800-3805,3811.
[25]
Nardelli S, Vizzutti F, Marra F, et al.Reply to: “post-TIPS OHE: are we really making a mountain out of a molehill?” [J].J Hepatol, 2024, 81(3):e118-e119.
[26]
Nicoară-Farcău O, Han G, Rudler M, et al.Pre-emptive TIPS in high-risk acute variceal bleeding.An updated and revised individual patient data meta-analysis [J].Hepatology, 2024,79(3): 624-635.
[27]
Lv Y, Bai W, Zhu X, et al.Development and validation of a prognostic score to identify the optimal candidate for preemptive TIPS in patients with cirrhosis and acute variceal bleeding [J].Hepatology, 2024, 79(1): 118-134.
[28]
Thiele M, Villesen IF, Niu L, et al.Opportunities and barriers in omics-based biomarker discovery for steatotic liver diseases [J].J Hepatol, 2024, 81(2):345-359.
[29]
Trebicka J, Hernaez R, Shawcross DL, et al.Recent advances in the prevention and treatment of decompensated cirrhosis and acute-on-chronic liver failure (ACLF) and the role of biomarkers[J].Gut, 2024, 73(6): 1015-1024.
[30]
Bullock AF, Patterson MJ, Paton LW, et al.Malnutrition,sarcopenia and cachexia: exploring prevalence, overlap, and perceptions in older adults with cancer [J].Eur J Clin Nutr, 2024,78(6): 486-493.
[31]
Kontogianni MD.Editorial: Adequate protein intake is more crucial than the profile of amino acids intake for sarcopenia prevention during the earlier stages of liver cirrhosis [J].Aliment Pharmacol Ther, 2024, 59(10): 1288-1289.
[32]
Cheng K, Li C, Wu H.Sarcopenia: it is time to attach more importance to this stealth killer in patients who are critically ill[J].Anaesthesia, 2024, 79(9):994-995.
[33]
Jindal A, Jagdish RK.Sarcopenia: ammonia metabolism and hepatic encephalopathy [J].Clin Mol Hepatol, 2019, 25(3):270-279.
[34]
Tuo S, Yeo YH, Chang R, et al.Prevalence of and associated factors for sarcopenia in patients with liver cirrhosis: a systematic review and meta-analysis [J].Clin Nutr, 2024,43(1):84-94.
[35]
Najm A, Niculescu AG, Grumezescu AM, et al.Emerging therapeutic strategies in sarcopenia: an updated review on pathogenesis and treatment advances [J].Int J Mol Sci, 2024,25(8): 4300.
[36]
Shi W, Xu W, Fan N, et al.Body compositions correlate with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a multicentre cohort study [J].J Clin Gastroenterol, 2025, 59(3):262-268.
[37]
Li Y, Guo Y, Wang X, et al.Association between sarcopenia and hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis: a systematic review and meta-analysis [J].Abdom Radiol (NY), 2024,49(2):575-585.
[38]
Tsien C, Shah SN, McCullough AJ, et al.Reversal of sarcopenia predicts survival after a transjugular intrahepatic portosystemic stent [J].Eur J Gastroenterol Hepatol, 2013, 25(1): 85-93.
[39]
Artru F, Miquet X, Azahaf M, et al.Consequences of TIPSS placement on the body composition of patients with cirrhosis and severe portal hypertension: a large retrospective CT-based surveillance [J].Aliment Pharmacol Ther, 2020, 52(9): 1516-1526.
[1] 孙宁, 王光毅, 朱丽菁, 冯苹, 何靖文, 张礼科, 易琟, 邱晨月, 伍国胜. 基于CiteSpace吸入性损伤研究现状和趋势的可视化分析[J/OL]. 中华损伤与修复杂志(电子版), 2025, 20(01): 22-29.
[2] 奚卫, 王闻卿, 刘玥, 王亚楠, 许学斌. 胃肠炎继发脓毒症感染创伤弧菌ST14514的病原学诊断与文献病例回顾分析[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(05): 293-302.
[3] 肖琦钦, 赵文丽, 任明君, 林丽丽, 刘尧, 苏展. 我国颞下颌关节专业学位论文的发展及演进分析[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(04): 250-256.
[4] 王子萌, 郑智, 闫笑生, 翟育豪, 张海翘, 徐瑞, 陈光勇, 刘小野, 尹杰, 张军. 胃癌前哨淋巴结研究的文献计量学与可视化分析[J/OL]. 中华普通外科学文献(电子版), 2025, 19(01): 34-41.
[5] 叶美妮, 刘思嘉, 臧玉玮, 刘云建. 肝硬化门静脉血栓形成的研究进展[J/OL]. 中华普通外科学文献(电子版), 2024, 18(05): 379-384.
[6] 刘阳, 郑宏, 孙碧红, 苑倩, 杨培, 郭海英, 李玉红. 基于CiteSpace 对毛囊干细胞在脱发领域相关文献的可视化分析[J/OL]. 中华细胞与干细胞杂志(电子版), 2025, 15(01): 30-40.
[7] 石洋, 郭辉, 李坚. 门静脉高压症TIPS操作规范及其手术相关并发症处理[J/OL]. 中华肝脏外科手术学电子杂志, 2025, 14(03): 372-378.
[8] 李月刚, 关旭, 赵志勋, 权继传, 庄孟, 汤坚强. 结直肠癌NOSES手术的国际研究现状[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(04): 321-328.
[9] 牛萌煊, 贺方正, 秦鑫, 王韦韦, 韩鹏飞, 李园. 单侧双通道内镜技术的全球研究趋势:一项文献计量学和可视化研究[J/OL]. 中华老年骨科与康复电子杂志, 2025, 11(03): 178-185.
[10] 方海丽, 王俊, 栾琳. HBV 相关慢加急性肝衰竭患者诱发肝性脑病风险列线图模型构建与验证应用[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(02): 144-148.
[11] 王玉琳, 王中华, 刘子文, 吕梦鑫, 于源滋, 李涛, 胡锦华, 张小茜. 肝硬化消化道出血患者经颈静脉肝内门体分流术前后肠道微生态的宏基因组学分析[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(02): 135-143.
[12] 张耕毓, 唐冲, 张昆, 张辉, 张清华, 刘家帮. 股骨头坏死髓芯减压术的文献计量学分析及单中心病例报道[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 771-780.
[13] 漆琳, 洪婷, 魏欣, 胡鸿, 蒲嘉骐, 廖运国, 邓兴, 李超, 邓丹, 唐梓瑜, 冯志鹏, 邱世香. 构建肝脏体模实施经颈静脉肝内门体分流术训练的方法学研究[J/OL]. 中华介入放射学电子杂志, 2025, 13(01): 62-67.
[14] 徐伟伟, 陈柳静, 吴帅, 刘佳. 文献计量学视角下我国消化科绩效管理发展情况分析[J/OL]. 中华胃食管反流病电子杂志, 2024, 11(04): 201-207.
[15] 陈娜娜, 韩莹, 胥青芝. 基于文献计量学的脑卒中吞咽障碍康复护理研究进展与临床热点趋势分析[J/OL]. 中华脑血管病杂志(电子版), 2025, 19(02): 100-108.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?