Clinical efficacy and safety analysis of bronchial artery chemoembolization with drug-loaded microspheres in the treatment of refractory non-small cell lung cancer

doi:10.3877/cma.j.issn.2095-5782.2024.04.004

Abstract

Abstract:

Objective

To investigate the clinical efficacy and safety of drug-loaded microspheres bronchial artery chemoembolization （D-BACE） in treating refractory non-small cell lung cancer （NSCLC）.

Methods

A retrospective analysis was conducted on 17 patients with stage Ⅲ～Ⅳ refractory NSCLC underwent D-BACE combined with systemic treatment （chemotherapy， targeted therapy， immunotherapy）from June 2018 to December 2022. The number of D-BACE treatments， median progression-free survival（PFS）， overall survival （OS）， disease control rate （DCR）， objective response rate （ORR）， and safety were recorded.

Results

The median number of D-BACE treatments was 1， ranging from 1 to 7 times. The ORR was 17.6%， and the DCR was 64.7%. The OS was 19.0 months， and the PFS was 9.5 months. No severe complications were observed； mild complications included chest numbness in 5 cases （29.4%）， pain in 8 cases （47.0%）， and nausea and vomiting in 5 cases （29.4%）.

Conclusion

D-BACE combined with systemic treatment can effectively control refractory NSCLC with minor adverse reactions， warranting further exploration and promotion.

Key words: Refractory non-small cell lung cancer, Drug-eluting beads, Bronchial arterial chemo embolization, Interventional radiology

Wei Cui, Suyi Ye, Yi Deng, Xiaoming Chen, Jing Zhang, Jing Li, Rongde Xu. Clinical efficacy and safety analysis of bronchial artery chemoembolization with drug-loaded microspheres in the treatment of refractory non-small cell lung cancer[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2024, 12(04): 311-316.

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URL: https://zhjrfsxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-5782.2024.04.004

https://zhjrfsxdzzz.cma-cmc.com.cn/EN/Y2024/V12/I04/311

Figures/Tables 4

指标	数据
年龄（岁， $\bar{x}$ ±s）	62.0±8.60
性别［例（%）］
男性	14（82.3）
女性	3（17.7）
ECOG评分［例（%）］
0	12（70.6）
1	2（11.8）
2	3（17.6）
吸烟史［例（%）］
是	9（52.9）
否	8（47.1）
TNM分期［例（%）］
Ⅲ	9（52.9）
Ⅳ	8（47.1）
既往治疗［例（%）］
化疗	14（82.3）
免疫治疗	5（29.4）
靶向治疗	6（35.3）
放疗	3（17.6）
局部治疗（粒子、MWA）	6（35.3）
几线治疗［例（%）］
2	9（52.9）
3	5（29.4）
＞3	3（17.6）
病理类型［例（%）］
腺癌	8（47.1）
鳞癌	8（47.1）
肉瘤样癌	1（5.9）
肿瘤位置［例（%）］
中央型	9（52.9）
外周型	8（47.1）
EGFR状态［例（%）］
野生型	13（76.5）
突变型	4（23.5）

指标	数据
年龄（岁， $\bar{x}$ ±s）	62.0±8.60
性别［例（%）］
男性	14（82.3）
女性	3（17.7）
ECOG评分［例（%）］
0	12（70.6）
1	2（11.8）
2	3（17.6）
吸烟史［例（%）］
是	9（52.9）
否	8（47.1）
TNM分期［例（%）］
Ⅲ	9（52.9）
Ⅳ	8（47.1）
既往治疗［例（%）］
化疗	14（82.3）
免疫治疗	5（29.4）
靶向治疗	6（35.3）
放疗	3（17.6）
局部治疗（粒子、MWA）	6（35.3）
几线治疗［例（%）］
2	9（52.9）
3	5（29.4）
＞3	3（17.6）
病理类型［例（%）］
腺癌	8（47.1）
鳞癌	8（47.1）
肉瘤样癌	1（5.9）
肿瘤位置［例（%）］
中央型	9（52.9）
外周型	8（47.1）
EGFR状态［例（%）］
野生型	13（76.5）
突变型	4（23.5）

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