Abstract:
Objective
To explore the clinical efficacy and safety of drug-eluting bead bronchial artery chemoembolization （D-BACE） in the treatment of rare non-small cell lung cancer （NSCLC）.
Methods
The clinical data of 8 patients with pathologically confirmed rare NSCLC who underwent D-BACE treatment were analyzed. The types of cancer included adenoid cystic carcinoma （3 cases），lymphoepithelioma-like carcinoma （2 cases）， SMACAR4-deficient lung cancer （2 cases）， and pulmonary sarcomatoid carcinoma （one case）. The clinical efficacy and safety of D-BACE were evaluated by observing objective response rate， disease control rate， progression-free survival （PFS）， and overall survival （OS）.Adverse reactions during the treatment process were also recorded and assessed.
Results
The average age of the patients was （51.0±3.4） years， with 5 males and 3 females. Among them， 1 patient underwent surgical resection in combination with D-BACE， 4 patients received chemotherapy and immunotherapy in combination with D-BACE， and 3 patients were treated with anlotinib in combination with D-BACE. After the first D-BACE treatment， the objective response rate was 25% （2/8）， and the disease control rate was 87.5% （7/8）. The median follow-up time was 18 months， with a median PFS of 6 months. The median OS has not yet been reached. Common adverse reactions included mild local pain （2 cases， 25%）， nausea and vomiting （2 cases， 25%）， fever （1 case， 12.5%）， and chest numbness （1 case， 12.5%）. All adverse reactions were mild and self-limited or relieved after symptomatic medication treatment. No serious complications were observed.
Conclusion
The combination of D-BACE and systemic treatment for rare non-small cell lung cancer is safe and feasible. However， further studies are needed to evaluate its long-term efficacy as the median overall survival has not yet been reached. The clinical value of D-BACE as a selective local treatment option warrants further exploration.
Key words:
Non-small cell lung cancer,
Drug-eluting beads,
Bronchial arterial chemoembolization
Wei Cui, Yi Deng, Suyi Ye, Jing Li, Xiaoming Chen, Jing Zhang, Rongde Xu. Clinical efficacy and safety of drug-eluting bead bronchial artery chemoembolization in the treatment of rare non-small cell lung cancer[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2024, 12(04): 303-310.