Abstract:

Objective

To explore the method of using anhydrous ethanol combined with Glubran-2 gel to treat Puig type Ⅲ venous malformation， and evaluate its clinical efficacy and safety.

Methods

The clinical data of 76 patients with Puig type Ⅲ venous malformation admitted to our hospital from January 2019 to January 2022 were retrospectively analyzed.The treatment of venous malformations was all percutaneous local treatment， using anhydrous ethanol combined with Glubran-2 glue.Among the 76 patients， there were 35 males and 41 females， aged 3-16 years （median age： 7 years）.The follow-up period ranged from 25 to 67 months （median follow-up time was 47 months）.

Results

The 76 patients recived local treatment for 1-3 times， with an average of （2.69±0.61） times.By the end of the follow-up period， 43 cases were cured， 26 cases showed significant relief，4 cases showed partial relief， and 3 cases were ineffecive.All patients had transient swelling of the lesion after surgery， with 4 cases of postoperaive hematuria and 3 cases of local tension blisters.No serious complications such as skin ulceration or ectopic embolism occurred.

Conclusion

The combination of anhydrous ethanol and Glubran-2 glue for the treatment of Puig type Ⅲ venous malformation is simple， safe， and reliable， with fewer complications.

Key words: Venous malformation, Anhydrous ethanol, Glubran-2 glue