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Chinese Journal of Interventional Radiology(Electronic Edition) ›› 2024, Vol. 12 ›› Issue (04): 380-385. doi: 10.3877/cma.j.issn.2095-5782.2024.04.016

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Novel molecular targeted therapy for sporadic venous malformations

Guangwei Wang1, Guilian Li2, Yong Wang2,()   

  1. 1.The Second Clinical College of Hainan Medical University,Hainan Haikou 570311
    2.Department of Interventional Radiology and Vascular Surgery,The Second Affiliated Hospital of Hainan Medical University,Hainan Haikou 570311,China
  • Received:2024-03-28 Online:2024-11-25 Published:2024-12-19
  • Contact: Yong Wang

Abstract:

Sporadic Venous Malformations (SVMs) is the most common type of venous malformations. It mainly presents with isolated and sporadic abnormal dilatation and malformations,accounting for more than 90% of all venous malformations. In recent years, the molecular mechanism of the pathogenesis of vascular malformations and related signal transduction pathways have been studied more and more thoroughly. Multiple pathogenic genes and related pathogenic signal pathways of SVMs have been confirmed, such as TIE2 and PIK3CA. For SVMs that are ineffective to conventional treatment, a variety of targeted drugs, such as Sirolimus and Apelisib, can control the development of SVMs, significantly improve the clinical symptoms of patients, and improve the quality of life, showing a good application prospect in the treatment of SVMs.

Key words: Sporadic Venous malformations, Targeted therapy, Sirolimus, Alpelisib, Afatinib

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