To investigate the effectiveness and safety of biliary stenting combined with¹²⁵I seeds strand in treatment of malignant biliary-enteric anastomotic stricture.

21 patients with biliary-enteric anastomotic stricture treated by ¹²⁵I seeds strand combined with metallic stent implantation were analyzed retrospectively. The procedural success rate, stent patency time, survival time and complications were recorded.

The median time of postoperative malignant biliary-enteric anastomotic stricture was 8 (3~78) months. 14 patients were implanted with single stent, 7 patients with double stents. The diameter of stents was (8~10) mm and the length of stents was (40~80) mm. The mean number of¹²⁵I implanted was (17.43 ± 5.65) (10~30). The levels of total bilirubin, direct bilirubin, alkaline phosphatase, gamma glutamyl peptidase, glutamic oxalacetic transaminase and glutamic pyruvic transaminase were lower post-operation than pre-operation, the decrease levels of total bilirubin, direct bilirubin, alkaline phosphatase, gamma glutamyl peptidase had significant statistical differences (P < 0.05), but the others had no statistical differences (P > 0.05). There werect no significant differences in tumor markers (AFP, CEA, CA125, CA199) before and after operation (P > 0.05). The complications include 4 cases (19.0%, 4/21) of controllable bleeding of bile duct, 1 case (4.8%, 1/21) of 125I seeds strand migration, 1 case (4.8%, 1/21) of bile duct stent fracture. The median stent patency time was (121.00 ± 17.55) (95%CI: 86.61~155.39) days and the median overall survival was (231.00 ± 45.61) (95%CI: 141.60~320.40) days.

¹²⁵I seeds strand combined with metallic stent implantation is safe and effective in the treatment of malignant biliary-enteric anastomotic stricture.