To evaluate the clinical therapeutic effect and safety of treatment of liver cancer complicated by main portal vein tumor thrombus (MPVTT) through transcatheter arterial chemoembolization (TACE) combined with percutaneous 125I radioactive seeds implantation sequential.

Among patients with liver cancer complicated by PVTT who were given interventional therapy at our hospital, 48 of them were diagnosed as liver cancer complicated by MPVTT and given percutaneous 125I radioactive seeds implantation sequential for portal vein tumor thrombus within one week after TACE operation. During the follow-up visit for 12-24 months, the changes of various clinical indicators and iconography before and after sequential therapy were compared to evaluate its therapeutic effect and safety.

48 Patients have been given totally 215 TACE therapies, 4.5 therapies for each patient in average, and 16 seeds were implanted into each patient in average, with the technical success rate of 100%. The treatment-related death did not occur in the whole group, and the objective remission rate of intrahepatic focal was 37.3% (18/48). The tumor thrombus averagely retracted by 3.9mm in imaging recheck after 3 months. 15 patients were with complete remission (CR), 25 patients with partial remission (PR), 6 patients with stable disease (SD), and 2 patients with progressive disease (PD), and the total remission rate (CR+PR) was 83.3%. 41 patients (85.4%) had portal vein trunk inner diameter recovered for above 80%. The 1-year and 2-year survival rate was respectively 47.9% and 33.33%, and the median survival time was (15.8±3.8) months. Compare the liver function and blood routine test results of 48 patients 3 months after operation with those during operation, P=0.028, and all the differences showed no statistical significance.

Treatment of liver cancer complicated by main portal vein tumor thrombus (MPVTT) through transarterial chemoembolization (TACE) combined with percutaneous 125I radioactive seeds implantation sequential is safety and effective.