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中华介入放射学电子杂志 ›› 2020, Vol. 08 ›› Issue (01) : 15 -18. doi: 10.3877/cma.j.issn.2095-5782.2020.01.004

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血管介入

TIPS术后门脉显影和肝脏体积对肝功能及并发肝性脑病的影响
申权1,(), 郑晖1, 杨维竹1, 郑曲彬1, 黄兢姚1, 黄宁1   
  1. 1. 350001 福建福州,福建医科大学附属协和医院介入科
  • 收稿日期:2020-01-02 出版日期:2020-02-25
  • 通信作者: 申权

Effect of the developing of portal vein after TIPS and liver volume on liver function and the incidence of hepatic encephalopathy

Quan Shen1,(), Hui Zheng1, Weizhu Yang1, Qubin Zheng1, Jingyao Huang1, Ning Huang1   

  1. 1. Department of Interventional Radiology, the Affiliated Union Hospital, Fujian Medical University, Fujian Fuzhou 350001, China
  • Received:2020-01-02 Published:2020-02-25
  • Corresponding author: Quan Shen
  • About author:
    Corresponding author: Shen Quan, Email:
引用本文:

申权, 郑晖, 杨维竹, 郑曲彬, 黄兢姚, 黄宁. TIPS术后门脉显影和肝脏体积对肝功能及并发肝性脑病的影响[J]. 中华介入放射学电子杂志, 2020, 08(01): 15-18.

Quan Shen, Hui Zheng, Weizhu Yang, Qubin Zheng, Jingyao Huang, Ning Huang. Effect of the developing of portal vein after TIPS and liver volume on liver function and the incidence of hepatic encephalopathy[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2020, 08(01): 15-18.

目的

探讨TIPS术后门脉显影及肝脏体积对术后肝功能及发生HE的影响。

方法

对94例肝硬化门脉高压患者行TIPS术,按术前肝功能Child-Pugh分级、肝脏体积及术后即刻门脉显影情况分组,3个月、6个月、1年随访,观察术后肝功能损害情况及有无发生HE,分析各组中肝功能损害情况及HE发生率的差异。

结果

TIPS术后患者肝功能均有不同程度损害,但绝大部分均能逐渐恢复。本组中1例出现肝功能损伤进展,最后并发肺炎及多脏器功能衰竭死亡,1例因腹腔内出血于术后3天死亡。肝功能Child A级组HE发病率10%(3/30),Child B级组HE发病率19.23%(10/52),Child C级组HE发病率41.67%(5/12),肝功能C级患者HE发病率明显高于A、B组,但无统计学差异(P>0.05);术后即刻门脉显影好的甲组中HE发病率17.81%(13/73),显影差的乙组中HE发病率23.81%(5/21),两组间差异无统计学意义(P>0.05);肝脏体积A组中HE发病率9.52%(4/42),B组中HE发病率26.92%(14/52),两组间差异有统计学意义(P<0.05)。

结论

TIPS术后即刻门脉显影好坏与术后肝性脑病发病率无明显相关;肝脏体积越小,术后肝性脑病发生率越高。

Objective

To evaluate the impact of the developing of portal vein after TIPS and liver volume on liver function and incidence of HE.

Methods

94 patients with liver cirrhosis portal hypertension underwent TIPS, were grouped according to preoperative liver function Child-Pugh classification, liver volume and the immediate portal vein development after TIPS. Follow-up was performed at 3 months, 6 months and1 year. Liver function and the incidence of HE were compared among the groups.

Results

The liver function of patients with TIPSS has been to various degrees damaged, but most of them could recover gradually. One case occurred liver function damage progress, eventually complicated by pneumonia and died of multiple organ failure. One case died of intraperitoneal hemorrhage 3 days after TIPSS. The incidence of HE in liver function Child A group, Child B group and Child C group were 10%(3/30), 19.23%(10/52) and 41.67%(5/12) respectively, the incidence of HE in Child C was apparently higer than those of Child A and B, but there were no statistical differences (P>0.05). The incidence of HE in group A with good immediate developing of portal vein was 17.81%(13/73), and that in group B with poor immediate developing of portal vein was 23.81%(5/21), without statisfical difference (P>0.05).The incidence of HE in liver volume A group and liver volume B group were 9.52%(4/42) and 26.92%(14/52) with statisfical difference (P<0.05).

Conclusions

The immediate developing of portal vein after TIPS was not significantly correlated with the incidence of HE.The smaller the liver volume, the higher the incidence of HE.

图1 TIPS术后门脉左右支即刻显影良好
图2 TIPS术中分流前门脉显影好
图3 TIPS术后即刻门脉左右支不显影(与图2同一病例)
表1 发生HE与术前肝功能Child-Pugh分级的关系
表2 发生HE与术后门脉显影的关系
表3 发生HE与肝脏体积的关系
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