Application of Gelatin Sponge-Iohexol Slurry in Percutaneous Liver Biopsy for Cirrhotic Patients with Moderate Thrombocytopenia

doi:10.3877/cma.j.issn.2095-5782.2026.02.009

Abstract

Abstract:

Objective

To evaluate the feasibility and safety of gelatin sponge-iohexol slurry for tract sealing after percutaneous liver biopsy in cirrhotic patients with moderate thrombocytopenia (PLT 20–50×10⁹/L).

Methods

A retrospective analysis was conducted on 60 patients with moderate thrombocytopenia who underwent CT-guided percutaneous liver biopsy at our hospital from March 2023 to March 2025. All patients underwent needle tract plugging with gelatin sponge-iohexol slurry immediately following the biopsy. The technical success rate, tract sealing success rate, and complication rates were evaluated.

Results

The technical success rates for both the biopsy procedure and tract sealing were 100%. Grade 1 bleeding occurred in 8 patients (13.3%), with no instances of Grade 2 or higher bleeding. Mild local pain was reported in 4 patients (6.7%). No complications such as puncture site infection, biliary injury, pneumothorax, fever, or non-target embolization occurred.

Conclusion

The use of gelatin sponge-iohexol slurry for tract sealing has preliminarily demonstrated safety and feasibility in cirrhotic patients with moderate thrombocytopenia.

Key words: cirrhosis, thrombocytopenia, percutaneous liver biopsy, gelatin sponge-iohexol slurry, puncture occlusion

Xiaojiao Shen, Xuerong Wu, Xiaoming Yan, Huiying Han, Jinyang Liu. Application of Gelatin Sponge-Iohexol Slurry in Percutaneous Liver Biopsy for Cirrhotic Patients with Moderate Thrombocytopenia[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2026, 14(02): 184-187.

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References 15

[1]	肖亮. 肝脏穿刺活检湘雅专家共识[J]. 中国普通外科杂志, 2021, 30(1): 1-8.
[2]	冯勇, 庄一平, 韦强, 等. 肝脏恶性病变经皮穿刺不同活检方式比较[J]. 临床放射学杂志, 2015, 34(5): 793-796.
[3]	Gangireddy VG, Kanneganti PC, Sridhar S, et al. Management of thrombocytopenia in advanced liver disease[J]. Can J Gastroenterol Hepatol, 2014, 28(10): 558-564.
[4]	Neuberger J, Patel J, Caldwell H, et al. Guidelines on the use of liver biopsy in clinical practice from the British Society of Gastroenterology, the Royal College of Radiologists and the Royal College of Pathology[J]. Gut, 2020, 69(8): 1382-1403.
[5]	McVay PA, Toy PT. Lack of increased bleeding after liver biopsy in patients with mild hemostatic abnormalities[J]. Am J Clin Pathol, 1990, 94(6): 747-753.
[6]	Chen MY, Yang AY, Hu YF, et al. Transjugular liver biopsy: enlarge the indications for liver biopsy with reliable diagnostic quality[J]. BMC Gastroenterol, 2023, 23(1): 282.
[7]	Midia M, Odedra D, Shuster A, et al. Predictors of bleeding complications following percutaneous image-guided liver biopsy: a scoping review[J]. Diagn Interv Radiol, 2019, 25(1): 71-80.
[8]	黄清博, 陈林, 封帆, 等. 医用胶封堵针道预防CT引导下肝穿刺活检后出血的有效性及安全性[J]. 中国介入影像与治疗学, 2024, 21(12): 729-732.
[9]	熊峻汶, 廖发超, 翟越, 等. 明胶海绵-凝血酶原-碘海醇用于封堵CT引导下经皮肝穿刺活检针道[J]. 中国介入影像与治疗学, 2024, 21(2): 75-78.
[10]	Rockey DC, Caldwell SH, Goodman ZD, et al. Liver biopsy[J]. Hepatology, 2009, 49(3): 1017-1044.
[11]	Tripodi A, Primignani M, Chantarangkul V, et al. Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion[J]. Liver Int, 2013, 33(3): 362-367.
[12]	Sasso R, Khalifa A, Guimaraes M, et al. Comparison of the safety of transjugular and percutaneous liver biopsies[J]. J Vasc Interv Radiol, 2023, 34(12): 2120-2127.
[13]	Zanetto A, Rinder HM, Senzolo M, et al. Reduced clot stability by thromboelastography as a potential indicator of procedure-related bleeding in decompensated cirrhosis[J]. Hepatol Commun, 2021, 5(2): 272-282.
[14]	Shah A, Amarapurkar D, Dharod M, et al. Coagulopathy in cirrhosis: a prospective study to correlate conventional tests of coagulation and bleeding following invasive procedures in cirrhotics[J]. Indian J Gastroenterol, 2015, 34(5): 359-364.
[15]	Yang X, Cheng HT, Huang Y, et al. Safety and efficacy of tract embolization using gelatin sponge particles in reducing pneumothorax after CT-guided percutaneous lung biopsy in patients with emphysema[J]. BMC Pulm Med, 2024, 24(1): 329.

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