Application of CT perfusion imaging in evaluation the changes of skeletal muscle perfusion before and after revascularization of lower limbs

doi:10.3877/cma.j.issn.2095-5782.2022.02.012

Abstract

Abstract:

Objective

To evaluate the skeletal muscle perfusion using CT perfusion imaging before and after interventional treatment in patients with lower extremity arteriosclerosis obliterans.

Methods

18 patients with lower extremity arteriosclerosis obliterans were included in the study. Endovascular treatment was performed according to standard procedures in one lower extremity. The other one without endovascular treatment was included in the control group. CT perfusion scans were performed 3 days before and after treatment to collect all image data. After the CT perfusion image was processed by VPCT Body software, the bilateral medial plantar muscles were selected symmetrically as the region of interest (ROI), and the perfusion parameters were obtained: blood flow (BF), blood volume (BV), and mean transit time (MTT) and permeability (PMB). Wilcoxon signed rank test was used to compare differences between perfusion parameters.

Results

18 patients were successfully treated with endovascular treatment. Before interventional therapy, there was no significant difference between BV, BF, PMB and MTT in the treatment group and the control group. After interventional therapy, the BV, BF and PMB in the treatment group were significantly higher than those in the control group, and MTT in the treatment group were significantly lower than that in the control group. Before and after interventional therapy, there were no significant differences in BV, BF, PMB and MTT in the control group. In the treatment group,BV, BF and PMB were significantly higher , and the MTT decreased significantly.

Conclusions

CT perfusion imaging can be used to measure and evaluate the change of perfusion in lower extremity skeletal muscle in real time, which has high clinical value.

Key words: Lower extremity, Digital subtraction angiography, Ischemia, Skeletal muscle, Spiral computed tomography

Tao Wang, Haobo Su, Xu He, Wensheng Lou, Guoping Chen, Cheng Qian, Yinghao Li, Jianping Gu. Application of CT perfusion imaging in evaluation the changes of skeletal muscle perfusion before and after revascularization of lower limbs[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2022, 10(02): 190-195.

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Figures/Tables 6

References 15

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项目		例数（%）或均数±标准差
性别
	男	11（61.1%）
	女	7（38.9%）
年龄（岁）		71.6±9.2
危险因素
高血压		12（66.6%）
	吸烟	8（44.4%）
	糖尿病	7（38.9%）
	高脂血症	8（44.4%）
临床分级（Rutherford分级）
	0级	0
	1级	0
	2级	0
	3级	6
	4级	8
	5级	4
	6级	0

项目		例数（%）或均数±标准差
性别
	男	11（61.1%）
	女	7（38.9%）
年龄（岁）		71.6±9.2
危险因素
高血压		12（66.6%）
	吸烟	8（44.4%）
	糖尿病	7（38.9%）
	高脂血症	8（44.4%）
临床分级（Rutherford分级）
	0级	0
	1级	0
	2级	0
	3级	6
	4级	8
	5级	4
	6级	0

	BV（mL/100 g）	BF（mL/100 g/min）	MTT（s）	PMB（mL/100 g/min）
治疗前（治疗侧）	3.009 ± 2.219	39.134 ± 32.110	8.123 ± 7.912	3.012 ± 6.775
治疗前（对照侧）	3.891 ± 4.123	22.101 ± 18.213	7.512 ± 7.876	8.914 ± 8.568
P值	0.518	0.081	0.301	0.152

	BV（mL/100 g）	BF（mL/100 g/min）	MTT（s）	PMB（mL/100 g/min）
治疗前（治疗侧）	3.009 ± 2.219	39.134 ± 32.110	8.123 ± 7.912	3.012 ± 6.775
治疗前（对照侧）	3.891 ± 4.123	22.101 ± 18.213	7.512 ± 7.876	8.914 ± 8.568
P值	0.518	0.081	0.301	0.152

	BV（mL/100 g）	BF（mL/100 g/min）	MTT（s）	PMB（mL/100 g/min）
治疗后（治疗侧）	6.309 ± 3.160	51.904 ± 41.684	3.128 ± 3.982	14.005 ± 8.365
治疗后（对照侧）	4.522 ± 3.985	21.886 ± 18.631	7.069 ± 7.996	8.773 ± 7.006
P值	0.011	0.022	0.047	0.040

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