Meta analysis: The clinical value of sodium alginate microspheres combined with transcatheter arterial chemoembolization in treating primary hepatocellular cancer

doi:10.3877/cma.j.issn.2095-5782.2016.04.002

Abstract

Abstract:

Objective:

To evaluate the clinical value of sodium alginate microspheres (KMG) combined with transcatheter arterial chemoembolization (TACE) in treating patients with primary hepatocellular carcinoma.

Methods:

A comprehensive search into the Cochrane library, PubMed, CNKI, CMB and WanFang databases was conducted with the key words of sodium alginate microspheres、hepatocellular carcinoma、transcatheter arterial chemoembolization. Relative studies published in these sources were first screened by three researchers based on double-blind acceptance and rejection criteria. The accepted studies were then analyzed by RevManManger 5.3.

Results:

In the selected 6 studies, a total of 497 patients, 225 received KMG+TACE, and 272 underwent TACE only. The Meta analysis showed that KMG combined with TACE could shrink the tumor size better compared with TACE (OR=4.15, 95%CI:2.38-7.24, P<0.05), and improve the 1 year survival rate (OR=2.53, 95%CI:1.71-3.75, P<0.05). No publication bias was found (P>0.05).

Conclusions:

KMG combined with TACE could shrink tumor size and improve the 1 year survival rate better than TACE, however, it could not alleviate the postoperative complications better. So comparatively, KMG combined with TACE has some superior clinical value in treating primary hepatocellular carcinoma.

Key words: Meta analysis, Sodium alginate microspheres, Transcatheter arterial chemoembolization, Hepatocellular carcinoma

Fuan Wang, Weifan Sui, Penghua Lyu, Guiling Li. Meta analysis: The clinical value of sodium alginate microspheres combined with transcatheter arterial chemoembolization in treating primary hepatocellular cancer[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2016, 04(04): 192-196.

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References 20

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作者	年份	例数	年龄（岁）	Child-Pugh分级	KMG^Δ	化疗药物剂量	术后血清AFP(μg/L)	术后肿瘤缩小例数	术后发热例数	术后消化道反应例数	术后腹痛例数	1年生存例数
刘太峰	2005	20/20	NG	A/B	100～400 μm	MMC10 mg/次、THP 20 ～ 40 mg/次	361.24±412.34/2 049.57±4 191.03	19/14	45/40	35/15	44/39	16/10
邹子扬	2006	23/23	49.5±2.2	A/B	150 ～450 μm	THP、5-FU、MMC均10 mg	7/2	18/12	21/19	15/16	NG	16/10
孙伟	2012	78/128	57.5	A/B	100～300 μm	吡喃阿霉素或羟基喜树碱20 ～30 mg	NG	36/24	NG	NG	NG	63/74
欧胜秋	2013	35/35	NG	A/B	N/A	THP30 ～ 60mg、奥沙利铂100～ 150 mg	NG	NG	NG	19/21	13/5	13/8
张志国	2015	30/30	51.3±10.5	A/B	100~450 μm	表阿霉素40~60mg/m²或吡喃阿霉素30~40 mg/m²）、铂类药物（顺铂30~40mg/m²、卡铂200~300 mg/m²或奥沙利铂90~120 mg/m²）、羟基喜树碱10~20mg/m²	1346.21±600.54/2013.68±1004.21	NG	27/28	12/15	26/27	24/15
黄秋峰	2016	39/36	56.8±8.2	A/B	0.5～2.0 g	羟基喜树碱15～30 mg、吡喃阿霉素40～60 mg	NG	NG	29/29	16/12	31/31	23/21

作者	年份	例数	年龄（岁）	Child-Pugh分级	KMG^Δ	化疗药物剂量	术后血清AFP(μg/L)	术后肿瘤缩小例数	术后发热例数	术后消化道反应例数	术后腹痛例数	1年生存例数
刘太峰	2005	20/20	NG	A/B	100～400 μm	MMC10 mg/次、THP 20 ～ 40 mg/次	361.24±412.34/2 049.57±4 191.03	19/14	45/40	35/15	44/39	16/10
邹子扬	2006	23/23	49.5±2.2	A/B	150 ～450 μm	THP、5-FU、MMC均10 mg	7/2	18/12	21/19	15/16	NG	16/10
孙伟	2012	78/128	57.5	A/B	100～300 μm	吡喃阿霉素或羟基喜树碱20 ～30 mg	NG	36/24	NG	NG	NG	63/74
欧胜秋	2013	35/35	NG	A/B	N/A	THP30 ～ 60mg、奥沙利铂100～ 150 mg	NG	NG	NG	19/21	13/5	13/8
张志国	2015	30/30	51.3±10.5	A/B	100~450 μm	表阿霉素40~60mg/m²或吡喃阿霉素30~40 mg/m²）、铂类药物（顺铂30~40mg/m²、卡铂200~300 mg/m²或奥沙利铂90~120 mg/m²）、羟基喜树碱10~20mg/m²	1346.21±600.54/2013.68±1004.21	NG	27/28	12/15	26/27	24/15
黄秋峰	2016	39/36	56.8±8.2	A/B	0.5～2.0 g	羟基喜树碱15～30 mg、吡喃阿霉素40～60 mg	NG	NG	29/29	16/12	31/31	23/21

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