Expression of Reactive Oxygen Species in Intracranial Aneurysms

doi:10.3877/cma.j.issn.2095-5782.2015.02.002

Abstract

Abstract:

Objective

To investigate the expression and role of reactive oxygen species (ROS) in intracranial aneurysms.

Methods

Intracranial aneurysms (n=29) and normal blood vessels (n=23) were harvested through surgery. The normal blood vessels were prepared as control group, the activity of xanthine oxidase(XO)and malondialdehyde(MDA)were measured. Rank-sum test was used to analyze the data.

Results

The levels of XO were significant higher in intracranial aneurysms segments compared with normal blood vessels segments ([20.66±7.45]U/gprot versus [5.32±0.98]U/gprot, respectively, P<0.01). The levels of MAD were significant higher in intracranial aneurysms segments compared with normal blood vessels segments ([8.35±5.06] nmol/gprot versus [3.61±0.52]nmol/gprot, respectively, P<0.01).

Conclusions

ROS was over-expressed in intracranial aneurysms and XO was an important source of ROS. XO-mediated ROS may contribute to the disease pathogenesis and play an important role in pathological progress of intracranial aneurysm.

Key words: Aneurysms, Reactive oxygen species, Xanthine oxidase

Li Li, Tianxiao Li, Liangfu Zhu, Jiangyu Xue, Ziliang Wang, Weixing Bai, Guang Feng. Expression of Reactive Oxygen Species in Intracranial Aneurysms[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2015, 03(02): 63-65.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhjrfsxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-5782.2015.02.002

https://zhjrfsxdzzz.cma-cmc.com.cn/EN/Y2015/V03/I02/63

References 14

1	Itoh Y, Takaoka R, Ohira M, et al. Reactive oxygen species generated by mitochondrial injury in human brain microvessel endothelial cells[J]. Clin Hemorheol Microcirc, 2006,34(1-2):163-168.
2	Guzik TJ, Sadowski J, Guzik B, et al. Coronary artery superoxide production and nox isoform expression in human coronary artery disease[J]. Arterioscler Thromb Vasc Biol, 2006,26(2):333-339
3	Juvela S, Poussa K, Porras M. Factors affecting formation and growth of intracranial aneurysms: a long-term follow-up study[J]. Stroke, 2001,32(2):485-491.
4	Hoi Y, Meng H, Woodward SH, et al. Effects of arterial geometry on aneurysm growth:three-dimensional computational fluid dynamics study[J]. J Neurosurg, 2004,101(4):676-681.
5	Wills S, Ronkainen A, van der Voet M, et al. Familial intracranial aneurysms: An analysis of 346 multiplex finnish families[J]. Stroke, 2003,34(6):1370-1374.
6	Sakaki T, Kohmura E, Kishiguehi T, et al. Loss and apoptosis of smooth muscle cells in intracranial aneurysms. Studies with in situ DNA end labeling and antibody against single-stranded DNA[J]. Acta Neurochir, 1997,139(5):469-475.
7	Gaetani P, Rodriguez Y, Baena R, et a1. Metalioproteases and intracranial vascular lesions[J]. NeurolRes, 1999,2l(4):385-390.
8	Kim SC, Singh M, Huang J, et al. Matrix metalloproteinase-9 in cerebral aneurysms[J]. Neurosurgery, 1997,4l(3):642-666.
9	Gavrila D, Li WG, McCormick ML, et al. Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice[J]. Arterioscler Thromb Vasc Biol, 2005,25(8):1671-1677.
10	Grigoryants V, Hannawa KK, Pearce CG, et al. Tamoxifen up-regulates catalase production, inhibits vessel wall neutrophil infiltration, and attenuates development of experimental abdominal aortic aneurysms[J]. J Vasc Surg,2005,41(1):108-114.
11	Miller FJ, Sharp WJ, Fang X, et al. Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling[J]. Arterioscler Thromb Vasc Biol, 2002,22(4):560-565.
12	Ejiri J, Inoue N, Tsukube T, et al. Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin Ⅱ type 1 receptor blocker[J]. Cardiovasc Res, 2003,59(4):988-996.
13	Grote K, Flach I, Luchtefeld M, et al. Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species[J]. Circulation Research, 2003,92(11):80-86.
14	Janiszewski M, Carmo AO, Pedro MA, et al. Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway[J]. Crit Care Med, 2004,32(3):818-825.

[1]	Juan Yin, Xing Yang, Ping Li, Minxin Xu, Yu Bao, Zhipeng Zhang, Hui Xue. The mechanism of anti-inflammatory and antioxidant effects of low-intensity pulsed ultrasound on lipopolysaccharide-induced RAW264.7 macrophage differentiation [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(01): 26-36.
[2]	Lu Zhao, Zheru Zhang, Junqi Jia, Chunlin Zong, Li Jing, Kai Guo, Lei Tian. The experimental study of M2 macrophages inhibiting the transformation of bone marrow mesenchymal stem cells into myofibroblasts after radiation [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2021, 15(04): 198-206.
[3]	Jianghe Zhang, Yuhong Li, Yujie Li, Hongzhuang Zhang, Yiming Zhang. The effect and potential mechanism of low level hydrogen peroxide on HaCat cell proliferation and wound healing in rat [J]. Chinese Journal of Cell and Stem Cell(Electronic Edition), 2021, 11(02): 75-82.
[4]	Wenqi Sun, Xinrong Wu, Yunrong Wang, Bei Zhao, Xiaotan Dou, Wen Li, Xiaoping Zou, Lei Wang, Min Chen. The value of measuring ROS and FH in colorectal epithelial cells for colorectal cancer screening [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(04): 326-330.
[5]	Huan Xiong, Yihao Zhu, Zhiqiao Hu, Ziming Yuan, Hanqing Hu, Qingchao Tang. Research progress of ferroptosis in colorectal diseases [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2021, 10(01): 86-89.
[6]	Yanchen Li, Jianning Li, Xiaowen Tu, Fengsheng Li. Progress of research on the role of ferroptosis in acute kidney injury caused by nuclear radiation [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(06): 338-341.
[7]	Jingyi Sun, Xuyan Liu, Wei Jiang. Research progress on the mechanism of podocyte injury mediated by NLRP3 inflammasome [J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(06): 267-271.
[8]	Yiming Du, Xin Chen, Shiguang Zhao. Progress of mechanism of oxidative stress in acute ischemic stroke [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2021, 07(02): 121-124.
[9]	Haiping Ling, Shijie Na, Tao Liu, Zong Zhuang, Yuhua Zhang, Qingrong Zhang, Chunhua Hang. Clinical efficacy analysis of stent assisted coil embolization in the treatment of intracranial blood blister-like aneurysm [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2021, 11(05): 263-267.
[10]	Wei Chen, Chaoyang Zhou, Bin Xi, Aijun Liang, Bin Zhou, Chunlian Liao, Xueju Cai, Dengfeng Wan. Clinical study of clipping ruptured anterior communicating aneurysms via contralateral pterional-craniotomy of dominant A1 [J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2020, 10(06): 323-326.
[11]	Aixia Chen, Pei Wu, Qiaowei Wu, Yuchen Li, Xuchen Hu, Jinbiao Yao, Pingbo Chen, Huaizhang Shi, Yuehua Wang. Safety and efficacy analysis of flow diverter only in the treatment of vertebrobasilar aneurysms [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2023, 11(03): 241-246.
[12]	Jian Jiao, Wenhan Li, Han Luo, Yajun Yuan, Wenhao Wang, Hanwei Liu, Benshuai Yu. Comparative analysis of the efficacy of Pipeline flow diverter and traditional stent-assisted coiling in the treatment of small and medium sized unruptured internal carotid artery aneurysms [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2023, 11(03): 223-229.
[13]	Zhuang Han, Zhenyu Jia, Wentao Wu, Linbo Zhao, Sheng Liu, Haibin Shi. The safety and efficacy of additional use of tirofiban in the treatment of intracranial fusiform aneurysms with stent-assistedcoiling (SAC) [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2022, 10(01): 11-15.
[14]	Shimeng Sun, Tianxiao Li, Li Li, Qiuji Shao, Kaitao Chang, Qiaowei Wu. Preliminary application of domestic Tubridge flow diverter in the treatment of vertebral artery dissecting aneurysm [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2021, 09(02): 160-164.
[15]	Shaoying Li, Ying Wen, Cuiping Jia, Yuan Zhang, Weihao Deng. The effect and implication of inhibiting glycotoxicity pathway on mitochondrial dysfunction [J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2023, 11(02): 65-70.

Please choose a citation manager

Content to export