To investigate the safety and efficacy of additional use of tirofiban during and within 24 h after the procedure in the treatment of intracranial fusiform aneurysms with stent-assisted coiling (SAC).

From January 2015 to December 2020, patients with intracranial fusiform aneurysms treated with SAC and intravenous administration of tirofiban 0.1 μg/kg/min were retrospectively collected in this study. The measured end points were rates of ischemic events, intracranial hemorrhage and 3 month modified Rankin Scale (mRS).

A total of 38 patients with 39 aneurysms were identified. Stent-assisted coiling was successful in all cases with single stent-assisted in 26 aneurysms and double stent-assisted in 13 aneurysms , achieving immediate complete aneurysm occlusion in 78.9% (30/38). At 6-month angiographic follow-up, complete aneurysm occlusion was obtained in 92.3% (24/26). Ischemic complications were observed in 7.9% (3/38) of patients. No intracranial hemorrhage was noted. Good outcomes (mRS 0-1) were observed in 97.4% (37/38) of patients at the 3-month follow up.

Additional use of tirofiban during and within 24h after the procedure appears to be a safe treatment for fusiform aneurysms treated with SAC.