Interventional therapeutic effect of hepatocellular carcinoma with obstructive jaundice

doi:10.3877/cma.j.issn.2095-5782.2013.02.012

Abstract

Abstract:

Objective

To investigate the of curative effect and its influencing factors of hepatocellular carcinoma with obstructive jaundice.

Methods

Percutaneous transhepatic biliary drainage（PTBD）were performed in 33 patients with hepatocellular carcinoma combined with obstructive jaundice，a part of them received transcatheter arterial chemoembolization（TACE）.

Results

All PTBD procedures were successful.The technical success rate was 100%，and seven stents were placed in 7 patients in 1 week after PTBD.Twenty-eight patients（84.84%，28/33）serum total bilirubin（TBIL）decreased after PTBD.Pruritus symptoms of skin gradually disappeared，liver function was significantly improved，and TACE was operated for one to six times with average 1.6 times.Nausea，anorexia，and fatigue gradually disappeared.Overall median survival was 8.0 months（mean：8.6 months，range 1～23 months）.TBIL decreased form 323.84μmol/L to 137.89μmol/L in 2 weeks after PTBD，TBIL decrease of 57.42%.Liver function failure and subsequent death occurred in 5 patients in 3 months with PTBD.

Conclusions

PTBD and TACE are effective palliative therapies in patients with HCC and obstructive jaundice.It can alleviate jaundice and improve the qualitly of life with long survival rate.But it's need to be cautious with poor liver function patients.

Key words: Hepatocelluar carcinoma, Obstructive jaundice, Interventional treatment

Duiping Feng, Chunming Xie, Minling Yang, Ningdong Pang, Yi Chen, Zhi-qiang Li, Ze-wen Su. Interventional therapeutic effect of hepatocellular carcinoma with obstructive jaundice[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2013, 01(02): 44-47.

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Figures/Tables 1

References 7

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检查时间	ALT（U/L）	AST（U/L）	ALB（g/L）	TBIL（μmoL/L）	DBIL（μmoL/L）
术前	135.90±144.11	156.38±100.89	29.45±6.63	323.84±108.90	151.93±89.93
术后1周	73.48±34.95	83.95±64.48	31.10±6.82	188.05±103.37	123.07±77.33
术后2周	64.33±56.72	85.92±136.65	32.09±7.30	137.89±121.05	87.26±71.16

检查时间	ALT（U/L）	AST（U/L）	ALB（g/L）	TBIL（μmoL/L）	DBIL（μmoL/L）
术前	135.90±144.11	156.38±100.89	29.45±6.63	323.84±108.90	151.93±89.93
术后1周	73.48±34.95	83.95±64.48	31.10±6.82	188.05±103.37	123.07±77.33
术后2周	64.33±56.72	85.92±136.65	32.09±7.30	137.89±121.05	87.26±71.16

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