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中华介入放射学电子杂志 ›› 2024, Vol. 12 ›› Issue (04) : 380 -385. doi: 10.3877/cma.j.issn.2095-5782.2024.04.016

综述

散发性静脉畸形的靶向治疗进展
王光伟1, 李桂莲2, 王勇2,()   
  1. 1.570311 海南海口,海南医科大学第二临床学院
    2.570311 海南海口,海南医科大学第二附属医院介入血管外科
  • 收稿日期:2024-03-28 出版日期:2024-11-25
  • 通信作者: 王勇

Novel molecular targeted therapy for sporadic venous malformations

Guangwei Wang1, Guilian Li2, Yong Wang2,()   

  1. 1.The Second Clinical College of Hainan Medical University,Hainan Haikou 570311
    2.Department of Interventional Radiology and Vascular Surgery,The Second Affiliated Hospital of Hainan Medical University,Hainan Haikou 570311,China
  • Received:2024-03-28 Published:2024-11-25
  • Corresponding author: Yong Wang
引用本文:

王光伟, 李桂莲, 王勇. 散发性静脉畸形的靶向治疗进展[J]. 中华介入放射学电子杂志, 2024, 12(04): 380-385.

Guangwei Wang, Guilian Li, Yong Wang. Novel molecular targeted therapy for sporadic venous malformations[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2024, 12(04): 380-385.

散发性静脉畸形(sporadic venous malformations,SVMs)是最常见的一种静脉畸形(venous malformations,VMs),主要表现为孤立、散发静脉血管的异常扩张和畸形,占所有静脉畸形的90%以上。近年来对血管畸形的发病的分子机制和相关信号传导通路研究越发透彻,SVMs多种致病基因与相关致病信号通路被证实,例如TIE2和PIK3CA;对于常规治疗无效的SVMs,多种靶向药物如西罗莫司、阿培利司等,可控制SVMs发展,显著改善患者临床症状,提高生活质量,在SVMs治疗中显示良好应用前景。

Sporadic Venous Malformations (SVMs) is the most common type of venous malformations. It mainly presents with isolated and sporadic abnormal dilatation and malformations,accounting for more than 90% of all venous malformations. In recent years, the molecular mechanism of the pathogenesis of vascular malformations and related signal transduction pathways have been studied more and more thoroughly. Multiple pathogenic genes and related pathogenic signal pathways of SVMs have been confirmed, such as TIE2 and PIK3CA. For SVMs that are ineffective to conventional treatment, a variety of targeted drugs, such as Sirolimus and Apelisib, can control the development of SVMs, significantly improve the clinical symptoms of patients, and improve the quality of life, showing a good application prospect in the treatment of SVMs.

图1 参与SVMs形成的细胞内信号通路和分子治疗的潜在靶点
表1 西罗莫司治疗SVMs的相关前瞻性研究
表2 西罗莫司治疗SVMs相关不良事件[6,29,30,34] [例(%)]
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