切换至 "中华医学电子期刊资源库"
高级检索
中华介入放射学电子杂志

中华介入放射学电子杂志 ›› 2018, Vol. 06 ›› Issue (04) : 352 -355. doi: 10.3877/cma.j.issn.2095-5782.2018.04.016

所属专题： 文献；

综述

腔内放射性粒子条的应用回顾及展望
包凯沪1, 顾建平2,†()   
  1. 1. 214400　东南大学附属江阴医院介入科
    2. 210006　南京医科大学附属南京医院（南京市第一医院）介入科
  • 收稿日期:2018-08-09 出版日期:2018-11-01
  • 通信作者: 顾建平

Review and prospect of application of intracavitary radioactive seeds strand

Kaihu Bao1, Jianping Gu2,†()   

  1. 1. Department of Inerventional Radiology, Jiangyin Affiliated Hospital, Southeast University, Jiangyin 214400, China
    2. Department of Inerventional Radiology, Nanjing First Hospital, Affiliated NanjingHospital of Nanjing Medical University, Nanjing 210006, China
  • Received:2018-08-09 Published:2018-11-01
  • Corresponding author: Jianping Gu
  • About author:
    Corresponding author: Gu Jianping, Email:
全文 ( ) 下载PDF ( ) 导出引用
引用本文：

包凯沪, 顾建平. 腔内放射性粒子条的应用回顾及展望[J]. 中华介入放射学电子杂志, 2018, 06(04): 352-355.

Kaihu Bao, Jianping Gu. Review and prospect of application of intracavitary radioactive seeds strand[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2018, 06(04): 352-355.

腔内放射性粒子条是参照放射治疗计划系统（TPS）使放射性粒子（如125I）在预先制作的管材内呈连续线性排列组合而成，是用于治疗恶性肿瘤腔道狭窄的低能放射源，其随着放射性125I粒子在各种肿瘤组织种植取得良好疗效的基础上，近些年逐步发展起来，并在胆道、体静脉血管、门静脉等腔道肿瘤控制方面取得了可喜的疗效。经空间布局优化的腔道内适形粒子条成为目前发展的方向。相关研究对不同肿瘤所致的恶性梗阻腔道内粒子条治疗效果及安全性等方面进行了总结，本文就此进行综述。

关键词: 放射性粒子条, 恶性梗阻, 125I粒子

The intracavitary radioactive seeds strand is a low-energy radioactive source for the treatment of malignant tumor stenosis, and it could be combined with radiotherapy treatment planning system (TPS) in a continuous linear arrangement of radioactive seeds (such as 125I) in pre-made tubing. Based on the good curative effect of various tumor tissue implants, radioactive 125I seeds have been gradually developed in recent years, and have achieved gratifying effects in the control of biliary, venous and portal vein tumors. The conformal seeds strand in the channel optimized by spatial layout has become the current development direction. The related research reviewed and summarized the therapeutic effect and safety of the seeds strand in the malignant obstruction caused by different tumors.

Key words: Radioactive seeds strand, Malignant obstruction, 125I seeds
[1]
杨敏捷,罗剑钧,刘清欣, 等. 125I粒子条剂量分布研究[J]. 介入放射学杂志, 2015, 24(1): 59-63.
[2]
戴真煜,姚立正,李文会, 等. 经皮胆道支架联合支架旁125I粒子条植入治疗恶性胆道梗阻[J]. 介入放射学杂志, 2011, 20(9): 706-708.
[3]
黄兢姚,杨维竹,江娜, 等. 125I粒子条胆道支架治疗恶性胆道梗阻38例[J]. 介入放射学杂志, 2014, 23(7): 633-636.
[4]
姜浩,赵辉,赵苏鸣, 等. 胆道支架及胆道支架联合125I粒子条植入治疗胆管癌伴阻塞性黄疸疗效评估[J]. 中国临床研究, 2015, 28(11): 1425-1428.
[5]
黄兢姚,杨维竹,江娜, 等. 经皮胆道支架联合支架内外粒子植入治疗胰头癌伴胆道梗阻[J]. 临床放射学杂志, 2015, 34(4): 629-633.
[6]
Ma J,Luo J,Gu J, et al. Malignant obstructive jaundice treated with intraluminal placement of Iodine-125 seed strands and metal stents: An analysis of long-term outcomes and prognostic features[J]. Brachytherapy, 2018, 17(4): 689-695.
[7]
张媛媛,马玉红,张福新. 胆道支架联合125I粒子植入治疗恶性梗阻性黄疸临床效果分析[J]. 中国现代普通外科进展, 2017, 20(2): 100-104.
[8]
姚红响,陈根生,叶冠雄, 等. 单纯胆道支架与125I粒子支架腔内照射治疗恶性梗阻性黄疸[J]. 中华肝胆外科杂志, 2014, 20(12): 869-872.
[9]
岳彦波. 125I粒子条联合胆道支架植入治疗恶性梗阻性黄疸的临床疗效分析[J]. 中外医疗, 2016, 35(21): 49-50.
[10]
尹晓翔,王志学,沈松鹤,朱鸷翔,吴涛.胆道支架联合125I粒子条置入治疗恶性阻塞性黄疸疗效分析[J]. 中国实用医药, 2015, (26): 94-95.
[11]
尹晓翔,王志学,沈松鹤, 等. 裸支架与裸支架联合125I粒子条治疗恶性梗阻性黄疸疗效对比分析[J]. 中国现代药物应用, 2015, 9(18): 75-76.
[12]
潘恒.新型胆道引流管的设计与临床应用研究[D]. 福建医科大学，2013.
[13]
姚红响,陈根生,叶冠雄, 等. 胆道支架联合125I粒子条治疗恶性梗阻性黄疸[J].介入放射学杂志, 2014, 23(10): 893-896.
[14]
刘明强,庄少鹉,刘丽莎.胆道支架联合125I粒子条置入治疗恶性胆道梗阻效果分析[J]. 福建医药杂志, 2016, 38(6): 28-30.
[15]
韩成龙,马亦龙,欧盛秋, 等. 125I粒子条联合胆道支架植入治疗恶性梗阻性黄疸22例疗效分析[J]. 介入放射学杂志, 2015, 24(2): 141-145.
[16]
罗剑钧. 腔内近距离放疗联合及支架植入治疗恶性胆道梗阻[J]. 介入放射学杂志, 2015, (3): 215-218.
[17]
Jiao D,Wu G,Ren J, et al. Study of self-expandable metallic stent placement intraluminal 125I seed strands brachytherapy of malignant biliary obstruction[J]. Surg Endosc, 2017, 31(12): 4996-5005.
[18]
黄兢姚,杨维竹,江娜, 等. 经皮胆道支架联合支架内外125I粒子植入治疗肝门部胆管癌研究[J]. 临床放射学杂志, 2016, 35(3): 448-452.
[19]
陈涛,朱晓黎,王万胜, 等. 125I粒子植入内照射治疗肝内胆管细胞癌疗效及安全性的初步分析[J]. 医学影像学杂志, 2017, 27(7): 1276-1280.
[20]
Yang M,Yan Z,Luo J, et al. A pilot study of intraluminal brachytherapy using 125I seed strand for locally advanced pancreatic ductal adenocarcinoma with obstructive jaundice[J]. Brachytherapy, 2016, 15(6): 859-864.
[21]
Zhang W,Yang ZQ,Shi HB, et al. Placement of 125I seed strands and stents for a type IV Klatskin tumor[J]. World J Gastroenterol, 2015, 21(1): 373-376.
[22]
Zhang W,Luo J,Liu Q, et al. Brachytherapy with Iodine-125 seeds strand for treatment of main portal vein tumor thrombi: an experimental study in a rabbit model[J]. Am J Cancer Res, 2016, 6(3): 587-599.
[23]
李说,颜志平,张雯, 等. 兔门静脉主干内植入连续排列125I粒子条的实验研究[J]. 介入放射学杂志, 2009, 18(8): 607-611.
[24]
王叙馥. 125Ⅰ粒子组织间植入治疗兔VX2移植性肝癌及对肝脏辐射损伤的实验研究[D]. 山东大学，2012.
[25]
毛晓楠,卢再鸣,郭启勇.门静脉支架联合125I粒子条植入治疗门脉癌栓12例[J]. 介入放射学杂志, 2016, 25(12): 1058-1064.
[26]
刘清欣,颜志平,李说, 等.125I粒子条联合门静脉支架及化疗栓塞治疗原发性肝癌合并门静脉癌栓[J]. 介入放射学杂志, 2009, 18(8): 593-595.
[27]
王晓维,付守忠,戴锋, 等. 门静脉支架及125I粒子条植入联合肝动脉栓塞化疗术治疗原发性肝细胞肝癌伴门静脉癌栓的效果观察[J]. 南通大学学报（医学版）, 2016, 36(4): 305-308.
[28]
李说. 连续线状排列125I粒子条联合金属支架+TACE治疗肝癌门静脉主干癌栓实验及临床研究[D]. 复旦大学，2009.
[29]
吴林霖,罗剑钧,颜志平, 等. 门静脉支架及经动脉药物治疗栓塞联合或未联合血管内植入碘-125粒子条治疗肝癌合并门静脉主干癌栓的比较[J]. 中华肝脏病杂志, 2012, 20(12): 915-919.
[30]
吴林霖,颜志平,张雯, 等. 经动脉灌注化疗联合125I粒子条治疗原发性肝癌合并门脉癌栓的疗效分析[J].介入放射学杂志, 2015, 24(9): 776-780.
[31]
余天柱,罗剑钧,颜志平. 血管内近程放疗与序贯三维适形放疗治疗门静脉主干癌栓的疗效对比[J]. 介入放射学杂志, 2017, 26(9): 787-792.
[32]
Tan T,Xiao Y,Zhou S, et al. Y-configuration stent combined with iodine-125 seeds strand for the treatment of hepatocellular carcinoma with tumor thrombosis in portal vein branches: A case report[J]. Medicine（Baltimore）, 2017, 96(46): e8660.
[33]
Yao LH,Su L,Liu L, et al. Stenting of the portal vein combined with different numbers of iodine-125 seed strands: Dosimetric analyses[J]. Chin Med J（Engl）, 2017, 130(18): 2183-2189.
[34]
Sun JH,Zhou T,Zhu T, et al. Portal vein stenting combined with iodine-125 seeds endovascular implantation followed by transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma patients with portal vein tumor thrombus[J]. Biomed Res Int, 2016, 2016: 3048261.
[35]
李文会,戴真煜,万豪光, 等.125I粒子条联合门静脉支架及TACE序贯索拉菲尼治疗肝癌合并门静脉主干癌栓[J].中华医学杂志, 2016, 96(23): 1838-1842.
[36]
武京鹏,何东风. 125I粒子条植入治疗原发性肝癌伴门静脉主干癌栓的近期疗效[J/CD]. 中华介入放射学电子杂志, 2015, 3(3): 144-147.
[37]
Yang M,Fang Z,Yan Z, et al. Transarterialchemoembolisation （TACE）combined with endovascular implantation of an iodine-125 seed strand for the treatment of hepatocellular carcinoma with portal vein tumor thrombosis versus TACE alone: a two-arm, randomised clinical trial[J]. J Cancer Res Clin Oncol, 2014, 140(2): 211-219.
[38]
Luo J,Yan Z,Liu Q, et al. Endovascular placement of iodine-125 seed strand and stent combined with chemoembolization for treatment of hepatocellular carcinoma with tumor thrombus in main portal vein[J]. J Vasc Interv Radiol, 2011, 22(4): 479-489.
[39]
涂文辉,罗剑钧,刘清欣, 等. 原发性肝癌伴门静脉主干癌栓患者存活超5年1例并文献复习[J]. 介入放射学杂志, 2015, 24(12): 1101-1106.
[40]
Zhang ZH,Zhang W,Gu JY, et al. Treatment of hepatocellular carcinoma with tumor thrombus with the use of iodine-125 seed strand implantation and transarterial chemoembolization: A propensity-score analysis[J]. J Vasc Interv Radiol, 2018, 29(8): 1085-1093.
[41]
Luo JJ,Zhang ZH,Liu QX, et al. Endovascular brachytherapy combined with stent placement and TACE for treatment of HCC with main portal vein tumor thrombus[J]. Hepatol Int, 2016, 10(1): 185-195.
[42]
Zhang W,Yan Z,Luo J, et al. Iodine-125 seeds strand for treatment of tumor thrombus in inferior vena cava: an experimental study in a rabbit model[J]. Cardiovasc Intervent Radiol, 2013, 36(5): 1371-1382.
[43]
郝红军,张兴仕,金鑫, 等.支架联合125I粒子条植入治疗肝癌所致下腔静脉恶性梗阻20例[J]. 介入放射学杂志, 2016, 25(6): 538-542.
[44]
杨清慧,张雯,颜志平, 等. 植入放射性支架联合经动脉化疗栓塞（TACE）治疗肝恶性肿瘤合并下腔静脉（IVC）梗阻[J]. 复旦学报（医学版）, 2014, 41(5): 617-623.
[45]
张雯. 线状排列125I粒子条及金属支架联合TACE治疗肝癌伴下腔静脉恶性梗阻的实验与临床研究[D]. 复旦大学，2010.
[46]
Gong M,Song J,He X, et al. Intraluminal brachytherapy using a self-expandable stent loaded with linear iodine-125 seeds in a patient with reiterative recurrence of cancer-associated vein obstruction: A case report with 3 months of follow-up[J]. Vasc Endovascular Surg, 2018, 52(6): 463-468.
[47]
Li W,Dai Z,Yao L, et al. Chemoembolization and stenting combined with iodine-125 seed strands for the treatment of hepatocellular carcinoma with inferior vena cava obstruction[J]. Exp Ther Med, 2015, 10(3): 973-977.
[1] 苏伟力, 齐二朋, 高元瑾, 刘方义, 韩治宇, 于晓玲. 超声引导放射性粒子治疗复发性肝癌的疗效及安全性评价[J]. 中华医学超声杂志（电子版）, 2020, 17(04): 296-299.
[2] 杜思韵, 付平, 盖保东, 杨冬艳. 超声引导下经皮穿刺植入放射性125I粒子治疗腹部恶性肿瘤[J]. 中华医学超声杂志（电子版）, 2019, 16(02): 142-146.
[3] 陈育贞, 马育璇, 王东方, 黄代营. 舌癌放射性125I粒子组织间植入的护理体会[J]. 中华口腔医学研究杂志(电子版), 2017, 11(03): 189-191.
[4] 袁殿宝, 翟明慧, 吴娜, 高会斌. 超声内镜引导下胆囊穿刺引流治疗低位恶性梗阻性黄疸的动物实验研究[J]. 中华普通外科学文献(电子版), 2022, 16(06): 412-416.
[5] 李衡, 吴清华, 刘昌贺, 袁艺文, 吕正颀. 可移动125I粒子条联合经皮肝胆管内外引流术治疗肝门部胆管癌的临床价值[J]. 中华介入放射学电子杂志, 2023, 11(01): 48-54.
[6] 李琴, 莫伟, 李玉莲, 阳秀春, 周碧芳. 恶性梗阻性黄疸患者经皮肝穿刺胆道引流术后家庭照顾者照护体验的质性研究[J]. 中华介入放射学电子杂志, 2022, 10(04): 451-455.
[7] 李刚, 王全义, 苏金旺, 丁洁, 高鹏, 陈学波. 新型125I双链胆道引流管治疗胆管癌合并黄疸的近期疗效（附9例报告）[J]. 中华介入放射学电子杂志, 2021, 09(04): 403-406.
[8] 李善凯, 胡效坤. XperCT辅助PTCD精准治疗恶性梗阻性黄疸的临床应用研究[J]. 中华介入放射学电子杂志, 2020, 08(02): 170-174.
[9] 武贝, 陈国平, 顾建平. 恶性肿瘤相关静脉血栓栓塞症及治疗进展[J]. 中华介入放射学电子杂志, 2019, 07(04): 322-329.
[10] 张宏涛, 刘晓丽, 周汝明, 于慧敏, 隋爱霞, 边艳珠, 王娟, 时高峰. SPECT/CT评价前列腺癌粒子植入剂量分布与疗效初探[J]. 中华介入放射学电子杂志, 2019, 07(04): 278-282.
[11] 张宏涛, 苏晓华, 梁岩松, 高贞, 于慧敏, 赵金鑫, 隋爱霞, 王娟. 3D打印模板联合CT引导粒子植入治疗前列腺癌一例报告并文献复习[J]. 中华介入放射学电子杂志, 2019, 07(03): 197-201.
[12] 高贞, 隋爱霞, 苑德月, 张宏涛, 于慧敏, 底学敏, 王泽阳, 王娟. 125I粒子植入联合引流治疗巨大肿瘤伴液化坏死的临床观察[J]. 中华介入放射学电子杂志, 2019, 07(02): 117-120.
[13] 张宗鹏, 张娟, 尹春辉. 放射性125I粒子条胆道支架联合靶向动脉置管化疗药物灌注对恶性梗阻性黄疸的疗效评价[J]. 中华介入放射学电子杂志, 2019, 07(01): 59-63.
[14] 齐莉恩, 王红, 孟箭, 王兴. 个体化导板辅助125I放射性粒子植入治疗头颈部恶性肿瘤的手术护理[J]. 中华介入放射学电子杂志, 2017, 05(02): 102-105.
[15] 赵素清, 杨海平, 毛宇. 内镜联合X线监视下支架植入治疗中晚期食管癌恶性梗阻的临床应用[J]. 中华胸部外科电子杂志, 2018, 05(03): 168-172.
阅读次数
全文


摘要

版权所有 中华医学会 中华医学电子音像出版社有限责任公司  京ICP备14006079号-1  网络出版服务许可证：(署)网出证(京)字第075号