Abstract:
Objective
This study aims to explore the accuracy of fractional flow reserve （FFR）measured by pressure wire at the proximal and distal ends of the lesion in chronic thromboembolic pulmonary hypertension.
Methods
This study consecutively enrolled patients （21 pulmonary arteries） with CTEPH who received BPA treatment at the Department of Respiratory and Critical Care Medicine， China-Japan Friendship Hospital， between February 2022 and August 2022.The FFR in the pulmonary arteries was measured using pressure wires， and PFG was calculated through selective pulmonary angiography.Correlation analysis was performed among FFR， PFG.
Results
In total， 18 patients with CTEPH were included in the study， including 11 （61.1%） male and 7 （38.9%） female patients， with an average age of 60.1 ± 10.5 years.In the 21 vessels of 18 patients， the FFR was 0.67±0.19.Vascular Distribution Characteristics： left lung： 8 blood vessels， all located in the left lower lobe.right lung： 13 blood vessels， distributed as follows： right upper lobe：5 vessels （38.5%）， right middle lobe： 1 vessel （7.7%）， right lower lobe： 7 vessels （53.8%）.Pulmonary Artery Blood Flow Classification： grade 0 blood flow： 1 vessel （4.8%）， grade 1 blood flow： 3 vessels （14.3%）， grade 2 blood flow： 3 vessels （14.3%）， grade 3 blood flow： 14 vessels （66.6%）.The results showed that there was a significant correlation between PFG and FFR （R= 0.937， P ＜0.0001）.
Conclusion
Fractional flow reserve（FFR） was an effective and precise evaluation method.It obtained via pressure wire measurement can guide balloon pulmonary angiography （BPA） treatment for CTEPH patients.
Key words:
Chronic thromboembolic pulmonary hypertension,
Balloon pulmonary angioplasty,
Pulmonary endarterectomy,
Fractional flow reserve,
Pulmonary artery flow grade
Jinzhi Wang, Yifan Wu, Xincao Tao, Wanmu Xie, Shuai Zhang, Yunxia Zhang, Zhu Zhang, Yu Zhang, Jixiang Liu, Linfeng Xi, Yishan Li, Qian Gao, Qiang Huang, Zhenguo Zhai. The assessment value of fractional flow reserve for hemodynamics in patients with chronic thromboembolic pulmonary hypertension[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2025, 13(01): 18-22.