Current status of balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension

doi:10.3877/cma.j.issn.2095-5782.2020.02.017

Abstract

Abstract:

Chronic thromboembolic pulmonary hypertension is classifed as Group-4 pulmonary hypertension caused by organized thrombi in pulmonary arteries. Pulmonary endarterectomy is the preferred treatment for CTEPH. The soluble guanylate cyclase stimulator (riociguat) is the sole FDA-licensed drug for the treatment of CTEPH. With the development of interventional therapy, balloon pulmonary angioplasty has gradually become new therapy for patients with inoperable CTEPH or residual or recurrent pulmonary hypertension following PEA. This article reviews the development process, indications, treatment procedures and complications of BPA to provide a better understanding and evaluation of BPA as a treatment option in CTEPH patients.

Key words: Chronic thromboembolic pulmonary hypertension, Balloon pulmonary angioplasty, Pulmonary embolism

Yangyi Zhou, Jianping Gu, Tao Wang. Current status of balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2020, 08(02): 184-188.

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References 43

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文献	年份	病例数	治疗次数	BPA前后mPAP变化（mmHg）	BPA前后PVR（Wood单位）	6 min步行试验（m）
Tatebe等^[24]	2016	55	193	35.0±9.0→24.0±6.0	6.0±2.8→2.8±1.0	408.0±181.0→482.0±146.0
Ogo等^[25]	2017	80	385	42.0±11.0→25.0±6.0	11.0±5.3→5.1±2.3	372.0±124.0→470.0±99.0
Ogawa等^[26]	2017	308	1 408	43.2±11.0→24.3±6.4	10. 7±5.6→4.5±2.8	318.1±122.1→401.3±104.8
Kwon等^[27]	2018	15	52	41.1±13.1→32.1±9.5	7.6±5.7→5.1±3.2	387.0±86.4→453.4±64.8
Van Thor等^[28]	2019	31	75	39.5±11.6→30.6±8.2	6.1±4.7→3.3±2.0	374.0±124.0→422.0±125.0
Hoole等^[29]	2020	30	90	44.7±11.0→34.4±8.3	8.3±3.5→5.5±2.5	366.0±107.0→440.0±94.0

文献	年份	病例数	治疗次数	BPA前后mPAP变化（mmHg）	BPA前后PVR（Wood单位）	6 min步行试验（m）
Tatebe等^[24]	2016	55	193	35.0±9.0→24.0±6.0	6.0±2.8→2.8±1.0	408.0±181.0→482.0±146.0
Ogo等^[25]	2017	80	385	42.0±11.0→25.0±6.0	11.0±5.3→5.1±2.3	372.0±124.0→470.0±99.0
Ogawa等^[26]	2017	308	1 408	43.2±11.0→24.3±6.4	10. 7±5.6→4.5±2.8	318.1±122.1→401.3±104.8
Kwon等^[27]	2018	15	52	41.1±13.1→32.1±9.5	7.6±5.7→5.1±3.2	387.0±86.4→453.4±64.8
Van Thor等^[28]	2019	31	75	39.5±11.6→30.6±8.2	6.1±4.7→3.3±2.0	374.0±124.0→422.0±125.0
Hoole等^[29]	2020	30	90	44.7±11.0→34.4±8.3	8.3±3.5→5.5±2.5	366.0±107.0→440.0±94.0

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