Abstract:

Objective

To explore a prevention and control technology for osteoporosis （OP） and concurrent vertebral compression fractures （OVCF） using a biodegradable polymer drug loaded alendronafe balloon （ALN balloon） combined with polymethylmethacrylate （PMMA）.

Methods

12-month-old female miniature Bama pigs were used to study， and the base-line of bone mineral density （BMD）， estradio （E2） and bone gla protein BGP （BGP） were measured. With bilateral ovariectomy， prednisolone-induced for 3 weeks，and sham operation， sham drug administration， the pigs are randomly divided into three groups： osteoporosis modeling group 1 （OM-1 group）， osteoporosis modeling group 2 （OM-2 group）， and sham osteoporosis modeling group （SOM group）. Based on percutanous vertebral augmentation （PVA）， OM-1 group with ALN balloon + PMMA， OM-2 group with non drug loaded balloon + PMMA， SOM group with ALN balloon +PMMA. BMD， E2， BGP are measured at the 0， 3rd， 6th months.

Results

Three months after PVA surgery，the BMD values of lumbar spine in the OM-1 group were higher than those of the OM-2 group， and the difference was statistically significant （P＜0.05）. With the increase of animal age， the BMD values of lumbar spine in the OM-1 group showed an increasing trend， while those in the OM-2 group showed a decreasing trend， and the difference between the two groups was statistically significant （P＜0.01）. After PVA surgery，with increasing age， E2 levels in the OM-1 and OM-2 groups significantly decreased， while BGP levels significantly increased， with statistically significant differences compared to baseline values （P＜0.01），and there was no statistically significant difference between the two groups （P＞0.05）.

Conclusion

ALN balloon+PMMA simultaneously has the effect of preventing and treating OVCF and OP.

Key words: Osteoporosis, Biphosphonates, Bone mineral density, PVA