To observe the clinical efficacy of low-pressure ozone water flushing with interventional catheterization in the treatment of patients with intra-thoracic/intra-abdominal infection combined with external fistula.

A total of 16 patients with intra-thoracic/intra-abdominal infection combined with external fistula caused by surgery or trauma were selected. Among them, 1-4 species of bacteria were detected in 14 patients. Under the guidance of DSA, the sinus was treated with persistent low-pressure ozone water flushing with interventional catheterization, and some patients were additionally treated with antibiotics. The changes in inflammatory indexes and clinical efficacy were observed.

Among the 16 patients, 7 were cured, 8 improved and 1 died of massive hemorrhage due to inflammation eroding large blood vessels during hospitalization. After treatment, leukocytes, neutrophils, C-reactive protein and procalcitonin decreased in varying degrees compared with those before treatment (P < 0.05). The time of using antibiotics accounted for 31.56% of the total hospital stay, and the cost of antibiotics accounted for 5.72% of the treatment cost.

DSA-guided ozone water flushing with interventional catheterization for the sinus in intra-thoracic/intra-abdominal infection combined with external fistula has certain clinical and social value. The treatment method needs to be further studied.