Clinical effect of microsphere embolization in treatment of non-small cell lung cancer with chemotherapy insensitivity

doi:10.3877/cma.j.issn.2095-5782.2018.03.009

Abstract

Abstract:

Objective:

To study the short-term and long-term therapeutic effects and survival of interventional microsphere embolization in the treatment of non-small cell lung cancer (NSCLC) invalid after chemotherapy.

Methods:

NSCLC patients (105 cases) who failed after chemotherapy during August 2011 to September 2015 in Angang General Hospital were as interventional embolization group (group A) , treated with embolization of bronchial artery using embosphere transcathter, re-examined after 3 months and re-embolized when necessary. NSCLC patients (76 cases) in our hospital during the same period were selected as chemotherapy control group (group B) , and treated with PE regimen and MIC regimen. The two groups were reviewed and evaluated every 3 months.

Results:

The effective rates of groups A and B were 74.3% and 45.5% (P=0.025) . The median survival time was 14.5 months and 11 months in groups A and B, respectively (P=0.042) .

Conclusion:

There are statistical difference between two ways. It is effective and safe for NSCLC failed by chemotherapy using interventional microsphere bronchial artery embolization.

Key words: Interventional therapy, Non-small cell lung cancer (NSCLC), Microsphere embolization, Chemotherapy

Dongming Ren, Xuan Li, Chengjun Sui, Ye Wang, Fengwei Zhou, Jie Liu, Dongyue Li, Cong Chen, Junting Liu. Clinical effect of microsphere embolization in treatment of non-small cell lung cancer with chemotherapy insensitivity[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2018, 06(03): 222-225.

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References 6

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组别	例数	年龄（岁，±s）	性别（男/女，例）	ECOG评分（例）			病理类型（例）			TNM分级（例）
组别	例数	年龄（岁，±s）	性别（男/女，例）	0	1	2	鳞癌	腺癌	其他	Ⅲa	Ⅲb	Ⅳa
栓塞组	105	65.20±12.24	67/38	16	33	56	62	38	5	17	48	40
对照组	76	64.45±13.48	51/25	14	23	39	41	28	7	11	37	28
统计量	?	t=1.296	χ²=0.211	?	Z=0.404	?	?	Z=0.875	?	?	Z=0.002	?
P值	?	0.195	0.646	?	0.686	?	?	0.382	?	?	0.999	?

组别	例数	年龄（岁，±s）	性别（男/女，例）	ECOG评分（例）			病理类型（例）			TNM分级（例）
组别	例数	年龄（岁，±s）	性别（男/女，例）	0	1	2	鳞癌	腺癌	其他	Ⅲa	Ⅲb	Ⅳa
栓塞组	105	65.20±12.24	67/38	16	33	56	62	38	5	17	48	40
对照组	76	64.45±13.48	51/25	14	23	39	41	28	7	11	37	28
统计量	?	t=1.296	χ²=0.211	?	Z=0.404	?	?	Z=0.875	?	?	Z=0.002	?
P值	?	0.195	0.646	?	0.686	?	?	0.382	?	?	0.999	?

组别	例数	CR	PR	SD	PD	RR(%)
栓塞组	105	34	44	21	6	74.3
对照组	76	9	26	31	10	45.5
χ²值	?	?	?	?	?	4.719
P值	?	?	?	?	?	0.025

组别	例数	CR	PR	SD	PD	RR(%)
栓塞组	105	34	44	21	6	74.3
对照组	76	9	26	31	10	45.5
χ²值	?	?	?	?	?	4.719
P值	?	?	?	?	?	0.025

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