To study the clinical efficacy and occurrence of complication of oral propranolol combined with local sclerotherapy for the treatment of large hemangioma in children.

Totally 237 infants (≤ 5 months old) with large hemangioma in Wuhan Children’s Hospital from January 2013 to April 2016 were selected and divided into two groups. The patients in simple treatment group (86 cases) were given local sclerosis treatment. Procedures were as follows: under the guidance of DSA or B ultrasound, multi-point puncture was performed on the tumor, after withdrawing blood, the sclerotherapy agent was slowly injected into the tumor tissue. The patients in combined treatment group (151 cases) were orally given propranolol combined with local sclerotherapy after 24 h long-term ECG is normal. 237 cases were followed up for 3 months to 1.5 years, and the clinical efficacy and complications in two groups were compared.

The total effective rate in combined treatment group was 96.7% (146/151) , which was higher than that of simple treatment group (89.5%, 77/86) , with significant difference (χ²=5.045, P<0.05) . The cure rate of combined treatment group was 71.5% (108/151) , which was higher than that of simple treatment group (47.7%, 41/86) , with significant difference (χ²=13.350, P<0.01) . The incidence of complications in combined treatment group was 25.8%, which was lower than that of the simple treatment group (38.4%) , with significant difference (χ²=4.077, P<0.05) .

Oral propranolol combined with local sclerotherapy is significantly better than the local sclerotherapy, with less comparison.