Clinical efficacy of combination therapy with ethanol+foam sclerotherapy+bleomycin A5+medical elastic sleeve for venous malformation in children

doi:10.3877/cma.j.issn.2095-5782.2017.04.005

Abstract

Abstract:

Objective:

To investigate the safety and efficacy of combination therapy with ethanol+foam sclerotherapy+bleomycin A5+ medical elastic sleeve for venous malformation in children.

Methods:

During the period of June 2013 to June 2016, a total of 188 children with venous malformations in Hebei Children’s Hospital were selected and divided into four types according to puig’s classification, such as type Ⅰ 48 cases, type Ⅱ 58 cases, type Ⅲ 52 cases and type Ⅳ 30 cases, and the patients were treated with combination therapy of ethanol, foam sclerotherapy, bleomycin A5 and medical elastic sleeve. The treatment results and complications were recorded and evaluated after one month.

Results:

The 188 children were averagely treated for three times, among which 98 cases were cured, 70 cases were improved, 20 cases were validly controlled, 13 cases had postoperative pain, and 3 cases had postoperative rupture. The adverse reaction rate was 8.5% (16/188) .

Conclusion:

Combination therapy of ethanol+ foam sclerotherapy+ bleomycin A5+medical elastic sleeve for venous malformation is an effective and safe therapy.

Key words: Venous malformations, Sclerotherapy, Ethanol, Sclerotherapy, Bleomycin A5, Children

Wenxian Zhang, Fangfang Li, Yifan Yang, Huiling Yang, Lei Xue. Clinical efficacy of combination therapy with ethanol+foam sclerotherapy+bleomycin A5+medical elastic sleeve for venous malformation in children[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2017, 05(04): 227-230.

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References 11

1	Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics[J]. Plast Reconstr Surg，1982，69(3):412-422.
2	Puig S, Aref H, Chigot V，et al. Classification of venous malformations in children and implications for sclerotherapy [J]. Pediatr Radiol，2003，33(2):99-103.
3	Breu FX, Guggenbichler S, Wollmann JC. 2nd European Consensus Meeting on Foam Selerotherapy 2006，Tegernsee，Germany. Vasa，2008，37(SupN 71)：1-29.
4	李龙，陈勇，李彦豪.关于影像引导下下肢静脉曲张泡沫硬化疗法技术操作规范的建议[J].中华医学杂志，2011，91(17):1218-1221.doi: 10.3760/cma.j.issn.0376-2491.2011.17.017.
5	王绪凯，谭海松，秦兴军.血管瘤及血管畸形治疗方法的选择[J].口腔颌面外科杂志，2012，22(3):153-156.doi：10.3969/j.issn.1005-4979.2012.03.001.
6	翁慧.小儿血管瘤瘤体注射聚桂醇的临床观察及护理[J].护理实践与研究，2011，8(5):55-56.doi：10.3969/j.issn.1672-9676.2011.05.026.
7	Do YS, Yakes WF, Shin SW，et al. Ethanol embolization of arteriovenous malformations: interim results [J]. Radionlogy，2005，235(2):674-682.
8	Steighner RJ, Povirk LF. Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage[J]. Proc Natl Aced Sci USA，1990，87(21):8350-8354.
9	曾庆乐，李彦豪，陈勇，等.平阳霉素碘油乳剂治疗肝海绵状血管瘤的临床应用[J].中华放射学杂志，2000，34(7):456.
10	杨伟洪，周汝明，向先俊，等.泡沫加液体混合硬化治疗低流量脉管畸形的初步研究[J/CD].中华介入放射学电子杂志，2016，4(4):211-215.doi：10.3877/cma.j.issn.2095-5782.2015.04.006.
11	周国瑜，张志愿，张陈平，等.口腔颌面部静脉畸形及血管瘤的激光治疗研究[J].中华口腔医学杂志，2005，40(3):200-202.doi: 10.3760/j.issn:1002-0098.2005.03.007.

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