Study on the Relationship Between CRP, NLR and Puncture-related Lower Extremity Arterial Thrombosis Following Placental Accreta Spectrum Balloon Occlusion

doi:10.3877/cma.j.issn.2095-5782.2026.03.006

Abstract

Abstract:

Objective

To investigate the relationship between C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and puncture-related lower extremity arterial thrombosis following abdominal aortic balloon occlusion combined with caesarean section in patients with placenta accreta spectrum (PAS).

Methods

A retrospective analysis was conducted on baseline data, serological indicators, and perioperative indicators of PAS patients treated at our hospital. Univariate and multivariate logistic regression analyses were performed to identify relevant factors. Receiver operating characteristic (ROC) curves were plotted to evaluate predictive value.

Results

The levels of CRP, NLR, D-dimer, and the amount of red blood cells transfused intraoperatively in the thrombus group differed significantly from those in the non-thrombus group (P < 0.05). Logistic regression analysis indicated that CRP, NLR, and D-dimer were associated with puncture-related lower extremity arterial thrombosis following balloon occlusion and cesarean section in PAS patients, with AUC values of 0.752, 0.710, and 0.703, respectively.

Conclusion

CRP and NLR were associated with early puncture-related lower extremity arterial thrombosis following abdominal aortic balloon occlusion and cesarean section in PAS patients.

Key words: Inflammatory, Placenta accreta spectrum, Balloon occlusion, Thrombosis, Punctures

Qiongfang Chang, Xinyi Hu, Di Feng, Juanfang Liu, Jianhao Zhang. Study on the Relationship Between CRP, NLR and Puncture-related Lower Extremity Arterial Thrombosis Following Placental Accreta Spectrum Balloon Occlusion[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2026, 14(03): 265-271.

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References 38

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组别	血栓组(n=52)	非血栓组(n=138)	P值
年龄[岁，M(Q₁，Q₃)]	34.00(32.00,37.00)	33.50(31.00,34.00)	0.083
孕周[周，M(Q₁，Q₃)]	35.00(33.00,35.00)	35.00(33.00,36.00)	0.445
BMI[kg/m²，M(Q₁，Q₃)]	28.04(25.78,30.47)	27.87(25.33,32.52)	0.868
怀孕次数[次，M(Q₁，Q₃)]	4.00(3.00,5.00)	4.00(3.00,5.00)	0.598
剖宫次数[次，M(Q₁，Q₃)]	2.00(1.00,2.00)	2.00(1.00,2.00)	0.327
胎盘评分[分，M(Q₁，Q₃)]	12.00(10.00,13.00)	12.00(11.00,13.00)	0.947
糖尿病[例(%)]	12.00(23.08)	32.00(23.19)	0.987

组别	血栓组(n=52)	非血栓组(n=138)	P值
年龄[岁，M(Q₁，Q₃)]	34.00(32.00,37.00)	33.50(31.00,34.00)	0.083
孕周[周，M(Q₁，Q₃)]	35.00(33.00,35.00)	35.00(33.00,36.00)	0.445
BMI[kg/m²，M(Q₁，Q₃)]	28.04(25.78,30.47)	27.87(25.33,32.52)	0.868
怀孕次数[次，M(Q₁，Q₃)]	4.00(3.00,5.00)	4.00(3.00,5.00)	0.598
剖宫次数[次，M(Q₁，Q₃)]	2.00(1.00,2.00)	2.00(1.00,2.00)	0.327
胎盘评分[分，M(Q₁，Q₃)]	12.00(10.00,13.00)	12.00(11.00,13.00)	0.947
糖尿病[例(%)]	12.00(23.08)	32.00(23.19)	0.987

指标	血栓组[n=52，M(Q₁，Q₃)]	非血栓组[n=138，M(Q₁，Q₃)]	P值
白细胞(×10⁹/L)	8.44(7.10, 9.81)	8.12(6.99, 9.61)	0.636
血小板(×10⁹/L)	197.00(181.50, 225.50)	194.50(152.00, 221.00)	0.155
单核细胞(×10⁹/L)	0.51(0.41, 0.62)	0.45(0.36, 0.57)	0.154
CRP(mg/L)	4.41(3.05, 5.38)	2.72(1.84, 3.56)	<0.001
NLR	5.10(4.53, 6.22)	4.08(3.45, 5.08)	<0.001
D-二聚体(mg/L)	0.92(0.63, 1.28)	0.63(0.45, 0.92)	<0.001
PT(s)	10.25(10.00, 10.70)	10.30(10.00, 10.50)	0.508
FIB(g/L)	3.61(3.40, 4.00)	3.49(3.25, 3.91)	0.324

指标	血栓组[n=52，M(Q₁，Q₃)]	非血栓组[n=138，M(Q₁，Q₃)]	P值
白细胞(×10⁹/L)	8.44(7.10, 9.81)	8.12(6.99, 9.61)	0.636
血小板(×10⁹/L)	197.00(181.50, 225.50)	194.50(152.00, 221.00)	0.155
单核细胞(×10⁹/L)	0.51(0.41, 0.62)	0.45(0.36, 0.57)	0.154
CRP(mg/L)	4.41(3.05, 5.38)	2.72(1.84, 3.56)	<0.001
NLR	5.10(4.53, 6.22)	4.08(3.45, 5.08)	<0.001
D-二聚体(mg/L)	0.92(0.63, 1.28)	0.63(0.45, 0.92)	<0.001
PT(s)	10.25(10.00, 10.70)	10.30(10.00, 10.50)	0.508
FIB(g/L)	3.61(3.40, 4.00)	3.49(3.25, 3.91)	0.324

组别	血栓组[n=52，M(Q₁，Q₃)]	非血栓组[n=138，M(Q₁，Q₃)]	P值
术中出血量（mL）	1 500.00(800.00, 2 500.00)	1 200.00(700.00, 2 000.00)	0.145
术中输红细胞量（U）	4.00(0.00, 4.00)	2.00(0.00, 4.00)	0.046
术中输血浆量（mL）	400.00(0.00, 400.00)	300.00(0.00, 400.00)	0.104
球囊放置时长（min）	259.50(206.00, 324.00)	267.00(213.00, 327.00)	0.985

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