Cervical spondylosis is a common and frequently occurring disease. With lifestyle changes and poor posture, its incidence is on the rise. Currently, the main minimally invasive treatment methods include radiofrequency ablation, laser ablation, collagenase lysis, and other technologies. Among these, collagenase has demonstrated positive long-term effects. However, ensuring that a sufficient amount of the drug solution reaches the target site remains a clinical challenge. This paper presents a retrospective analysis of six cases using an anterior approach for collagenase injection into the anterior epidural space, directly targeting the protruding surface of the nucleus pulposus. This technique may enhance drug delivery to the lesion and provide a new therapeutic option for the treatment of cervical spondylosis.

The clinical experience of the anterior approach for targeted collagenase injection into cervical discs was retrospectively analyzed in six patients treated at the Department of Minimally Invasive Intervertebral Disc Intervention, Shaanxi Second People's Hospital, from August 2024 to September 2024. The key technical points of the procedure were summarized.

All six patients were successfully discharged after the procedure. No postoperative complications such as nausea, vomiting, headache, or dizziness occurred, and no severe adverse events such as bleeding or inadvertent drug entry into the subarachnoid space were observed.

The anterior approach of collagenase injection into the anterior epidural space appears to be a feasible, safe, and reliable technique for the treatment of cervical spondylosis.