To investigate the preparation, physicochemical characterization of iron-copper-based metal-organic frameworks (Fe-Cu MOFs) nanomaterials combined with microwave ablation in treating Hepatocellular Carcinoma.

Fe-Cu MOFs nanomaterials were synthesized by hydrothermal method, their physicochemical characteristics were observed, and the microwave sensitization ability was evaluated by measuring the microwave heating effect of different concentrations (0, 2, 6, 10 mg/mL)in vitro. In addition, biocompatibility was evaluated at the cellular level, and the inhibitory effect of combined therapy with microwave ablation on cell proliferation was explored. Subsequently, a subcutaneous tumor model in H22 Hepatocellular Carcinoma mice was established to evaluate the inhibitory effect of Fe-Cu MOFs combined with MW on tumor growth.

Fe-Cu MOFs nanomaterials with a faceted structure and a particle size of (182.28 ± 0.79) nm was successfully synthesized. The heating effect under microwave irradiation increased with the duration and concentration of the nanomaterials. Fe-Cu MOFs combined with microwave irradiation notably suppressed tumor cell proliferation. In vivo studies showed that mice treated with Fe-Cu MOFs and microwaves exhibited higher tumor site temperatures and significantly reduced tumor volumes compared to microwave-only treatment.

Fe-Cu MOFs nanomaterials have good microwave sensitization properties, which can effectively improve the therapeutic effect of microwave ablation in Hepatocellular Carcinoma.