Clinical effects of angioplasty combined with catheterized thrombolysis in treatment of arteriosclerosis obliterans of lower extremities

doi:10.3877/cma.j.issn.2095-5782.2018.03.011

Abstract

Abstract:

Objective:

To compare the clinical effects of angioplasty combined with catheterized thrombolysis and conventional angioplasty in the treatment of lower extremity arterial occlusive disease.

Methods:

From January 2014 to December 2015, clinical data of 33 patients with lower extremity ASO treated by different ways were analyzed, including 18 cases with routine interventional therapy (routine group) and 15 ones with interventional and thrombolytic therapy (thrombolysis group) . The clinical results in two groups were analyzed and compared.

Results:

Technical success rates were 88.89% in routine group and 93.33% in thrombolysis group. The clinical total effective rate in thrombolysis group was higher than that of routine group (100% vs. 88.89%) . The ABI values in both groups were significantly increased after operation, and the increase rate of ABI in thrombolysis group was larger than that in routine group (P<0.05) . The complications about thrombosis of thrombolysis group were lower than those of routine group. After 3, 6, 12 and 24 months of operation, the primary patency rates were 83.33%, 83.33%, 72.22% and 62.50% respectively in routine group, and 100%, 100%, 80.00% and 71.43% respectively in thrombolysis group. The primary patency in the thrombolysis group was much better than that in the routine group.

Conclusion:

For patients with ASO, the value of interventional treatment combined with thrombolysis is better than that of only routine interventional option.

Key words: Arteriosclerosis obliterans, Interventional therapy, Thrombolysis, Lower limb ischemia

Xingjie Wu, Shugui Huang, Jun Deng, Jun Li, Ping Fang, Wei Zhu. Clinical effects of angioplasty combined with catheterized thrombolysis in treatment of arteriosclerosis obliterans of lower extremities[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2018, 06(03): 232-236.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhjrfsxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-5782.2018.03.011

https://zhjrfsxdzzz.cma-cmc.com.cn/EN/Y2018/V06/I03/232

Figures/Tables 6

References 10

[1]	郑月宏，廖鹏志.下肢动脉硬化闭塞症治疗现状与展望[J].中华老年多器官疾病杂志，2016，15（3）：161-164.
[2]	李成学，王波涛，李建红，等.下肢动脉硬化闭塞症的腔内介入治疗及疗效观察[J].当代医学，2011，17（5）:15-17.
[3]	包俊敏.下肢动脉闭塞腔内治疗策略的新思考[J/CD].中国血管外科杂志（电子版），2017，9（2）:81-83.
[4]	Indes JE，Pfaff MJ，Farrokhyar F，et al. Clinical outcomes of 5358 patients undergoing direct open bypass or endovascular treatment for aorto-iliac occlusive disease: a systematic review and meta-analysis[J].J Endovasc Ther，2013，20（4）:443-455.
[5]	姚陈，叶彦琛，李勇辉，等.股浅动脉硬化闭塞症腔内治疗效果分析[J/CD].中国血管外科杂志（电子版），2015，7（3）:170-174.
[6]	王佩双，胡何节，方征东，等.股腘动脉闭塞腔内成形术与旁路转流术的临床疗效对比分析[J/CD].中国血管外科杂志（电子版），2014，6（1）:41-44.
[7]	Kitrou P，Parthipun A，Diamantopoulos A，et al. Targeted true lumen re-entry with the Outback catheter: accuracy，success，and complications in 100 peripheral chronic total occlusions and systematic review of the literature[J]. J Endovasc Ther，2015，22（4）:538-545.
[8]	钱结胜，朱康顺，姜在波，等.经桡、股动脉序贯途径腔内治疗下肢动脉硬化闭塞症[J].当代医学，2010，16（29）:516-520.
[9]	宋盛晗，王克勤，张望德.溶栓介入治疗主髂动脉闭塞伴血栓形成一例[J/CD].中华介入放射学电子杂志，2016，4（1）:48-50.
[10]	Bagan P，Dakhil B，Lacal P，et al. Acute peripheral arterial occlusion: prospective study evaluating intra-arterial thrombolysis with a micro-porous balloon catheter[J]. J Endovasc Ther，2013，20（3）:422-426.

组别	例数	性别（男/女）	年龄[岁，(±s)]	病程[年，(±s)]	Fontaine分期（例）Ⅰ/Ⅱ/Ⅲ/Ⅳ
常规组	18	12/6	70.11±5.57	9.56±3.15	0/5/9/4
溶栓组	15	11/4	71.13±5.82	10.33±3.18	0/5/7/3
统计量	?	χ²=0.172	t=-0.514	t=-0.704	Z=-0.314
P值	?	0.68	0.61	0.49	0.75

组别	例数	性别（男/女）	年龄[岁，(±s)]	病程[年，(±s)]	Fontaine分期（例）Ⅰ/Ⅱ/Ⅲ/Ⅳ
常规组	18	12/6	70.11±5.57	9.56±3.15	0/5/9/4
溶栓组	15	11/4	71.13±5.82	10.33±3.18	0/5/7/3
统计量	?	χ²=0.172	t=-0.514	t=-0.704	Z=-0.314
P值	?	0.68	0.61	0.49	0.75

组别	例数	术前	术后2周	术后3个月	术后6个月	F值	P值
常规组	18	0.42±0.11	0.72±0.07	0.69±0.07	0.65±0.06	4.723	0.036
溶栓组	15	0.43±0.09	0.83±0.07	0.79±0.07	0.73±0.06	5.555	0.025
t值	?	-0.253	-4.622	-4.118	-3.969	?	?
P值	?	0.800	0.001	0.001	0.001	?	?

组别	例数	术前	术后2周	术后3个月	术后6个月	F值	P值
常规组	18	0.42±0.11	0.72±0.07	0.69±0.07	0.65±0.06	4.723	0.036
溶栓组	15	0.43±0.09	0.83±0.07	0.79±0.07	0.73±0.06	5.555	0.025
t值	?	-0.253	-4.622	-4.118	-3.969	?	?
P值	?	0.800	0.001	0.001	0.001	?	?

组别	例数	穿刺点出血	血肿	血管通畅
组别	例数	穿刺点出血	血肿	3个月	6个月	12个月	24个月
常规组	18	2(11.11)	4(22.22)	15(83.33)	15(83.33)	13(72.22)	10(62.50*)
溶栓组	15	10(66.67)	4(26.67)	15(100.00)	15(100.00)	12(80.00)	10(71.43*)
χ²值	?	10.913	0.088	2.461	2.461	2.701	0.423
P值	?	0.001	0.770	0.233	0.233	0.604	0.520

Please choose a citation manager

Content to export