To evaluate the effect of the different methods of percutaneous transhepatic biliary drainage (PTBD) to treat the patients with the malignant obstructive jaundice throught this prospective clinical control study.

There are 91 consecutive cases with the malignant objective jaundice (M:F=57:34), mean age (60.4±11.6 years) who were selected by our standard were accepted PTBD therapy. The patients who undergo PTIEBD will be send into three group at random: group IED-A (turn off drainage for 2 h after each meal) 20 cases, group IED-B (turn off drainage duaring daytime) 20 cases, group IED-C (turn off drainage persistently) 15 cases. Thirty-six patients underwent PTIEBD. TBIL, DBIL, AST, ALP before operation and 2—4 days, 8—10 days, and 1 month after the operation were analyzed by ANOVA test.

There is no obvious difference in TBIL, DBIL, AST, ALP among these groups before operation (P>0.05). At 1 month after PTBD, the level of TBIL, DBIL: group IED-B>group IED-A>group ED, and the difference between three group is obvious(P<0.05); the level of AST: group ED>group IED-A>group IED-B, and comparing group ED with group IED-A or group IED-B, the difference is obvious(P<0.05); the level of ALP: group IED-B>group IED-A>group ED, and comparing group IED-B with group IED-A or group ED, the difference is obvious (P<0.05). TBIL、DBIL、AST、ALP did not descend obviously after operation in IED-C group (P>0.05).

The different drainage has its own benefit, we should adopt the drainage according to the patient’s situation. Turn-off drainage is not recommended.