Evaluation the efficacy of 125I seed strand implantation for treatment of hepatocellular carcinoma with main portal vein tumor thrombus

doi:10.3877/cma.j.issn.2095-5782.2015.03.008

Abstract

Abstract:

Objective

To discuss the therapeutic efficacy and safety of ¹²⁵I seed strand implantation for treatment of hepatocellular carcinoma (HCC) with main portal vein tumor thrombus (MPVTT).

Methods

A total of 15 patients with confirmed HCC accompanied by MPVTT received implantation of ¹²⁵I seed strand via portal vein. The procedure was guided by ultrasound and DSA. The hepatic function, routine blood test as well as coagulation function, the changes of PVTT and the postoperative complications were analyzed.

Results

The implantation of ¹²⁵I seed strand was successfully accomplished in all the patients. The objective response rate of MPVTT was 40.00% (6/15) and the disease control rate was 86.67% (13/15). There was no significant difference between preoperative and postoperative two months in hepatic function, routine blood test and coagulation function. No serious procedure-related complications occurred.

Conclusions

Implantation of ¹²⁵I seed strand is safe, feasible and effective to treat MPVTT in HCC.

Key words: Liver neoplasms, Main portal vein tumor thrombus, ¹²⁵I seed strand

Jingpeng Wu, Dongfeng He. Evaluation the efficacy of ¹²⁵I seed strand implantation for treatment of hepatocellular carcinoma with main portal vein tumor thrombus[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2015, 03(03): 144-147.

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References 29

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项目		例数(%)
性别
?	男	12(80.00)
?	女	3(20.00)
年龄(岁)，平均值(范围)		57.6(36～79)
肝炎病史
?	有	13(86.67)
?	无	2(13.33)
肝功能分级
?	Child-Pugh A级	10(66.67)
?	Child-Pugh B级	5(33.33)
ECOG评分
?	0+1	12(80.00)
?	2	3(20.00)
AFP值(ng/ml)
?	≥400	9(60.00)
?	<400	6(40.00)
肿瘤类型
?	巨块型	5(33.33)
?	结节型	8(53.34)
?	混合型	2(13.33)
PVTT分布
?	主干+左支和右支	2(13.33)
?	主干+左支或右支	10(66.67)
?	左支或右支	3(20.00)

项目		例数(%)
性别
?	男	12(80.00)
?	女	3(20.00)
年龄(岁)，平均值(范围)		57.6(36～79)
肝炎病史
?	有	13(86.67)
?	无	2(13.33)
肝功能分级
?	Child-Pugh A级	10(66.67)
?	Child-Pugh B级	5(33.33)
ECOG评分
?	0+1	12(80.00)
?	2	3(20.00)
AFP值(ng/ml)
?	≥400	9(60.00)
?	<400	6(40.00)
肿瘤类型
?	巨块型	5(33.33)
?	结节型	8(53.34)
?	混合型	2(13.33)
PVTT分布
?	主干+左支和右支	2(13.33)
?	主干+左支或右支	10(66.67)
?	左支或右支	3(20.00)

项目	术前	术后2个月	t值	P值
ALT/(U/L)	57.63±29.80	51.59±32.78	0.646	0.529
AST/(U/L)	77.40±41.38	68.27±54.59	0.742	0.470
BILT/(μmol/L)	25.24±7.27	22.46±9.92	1.234	0.237
ALB/(g/L)	41.67±4.12	39.71±3.89	1.973	0.069
WBC/(×10⁹/L)	5.26±1.64	5.29±1.30	-0.111	0.913
PLT/(×10⁹/L)	138.80±58.38	136.27±56.13	0.324	0.751
PT/(s)	12.48±0.81	12.20±1.11	1.245	0.234

项目	术前	术后2个月	t值	P值
ALT/(U/L)	57.63±29.80	51.59±32.78	0.646	0.529
AST/(U/L)	77.40±41.38	68.27±54.59	0.742	0.470
BILT/(μmol/L)	25.24±7.27	22.46±9.92	1.234	0.237
ALB/(g/L)	41.67±4.12	39.71±3.89	1.973	0.069
WBC/(×10⁹/L)	5.26±1.64	5.29±1.30	-0.111	0.913
PLT/(×10⁹/L)	138.80±58.38	136.27±56.13	0.324	0.751
PT/(s)	12.48±0.81	12.20±1.11	1.245	0.234

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