利用主客体互倚模型探讨¹²⁵I粒子植入患者及其照顾者的病耻感对彼此生活质量的影响，为制定针对性护理干预策略提供依据。

采用便利抽样法，选取2023年1月至2024年1月江阴市人民医院收治的共80对¹²⁵I粒子植入患者及其主要照顾者为研究对象。使用社会影响量表评估患者病耻感，连带病耻感量表评估照顾者病耻感，简版生活质量量表评估两组生活质量。采用Pearson相关分析检验变量间关联性，并建立主客体互倚模型。通过主客体互倚模型路径分析量化主体效应与客体效应。

¹²⁵I粒子植入患者病耻感得分（58.95±12.38）高于照顾者（46.38±7.93），生活质量中患者躯体生活质量总分（42.94±10.33）、心理生活质量总分（29.81±8.39）均低于照顾者［分别为（49.15±9.49）、（37.26±8.58）］，差异均有统计学意义（病耻感：t=8.578，躯体生活质量：t=-3.962，心理生活质量：t=-5.555，均P<0.001）；患者病耻感与自身躯体生活质量（r=-0.733，P<0.001）、心理生活质量（r=-0.660，P<0.001）均呈负相关；照顾者病耻感与自身躯体生活质量（r=-0.563，P<0.001）、心理生活质量（r=-0.448，P<0.001）亦均呈负相关。主体效应：患者（β=-0.808）和照顾者（β=-0.947）的病耻感均显著负向预测自身躯体健康；客体效应：照顾者的病耻感对患者心理健康具有显著负向预测作用（β=-0.808, P<0.05），但患者病耻感对照顾者生活质量无显著影响（β=0.397, P=0.273；β=-0.655，P=0.092）。

¹²⁵I粒子植入患者与照顾者的病耻感处于较高水平且患者病耻感程度高于其照顾者；病耻感通过“主体-客体”双路径影响患者及照顾者的生活质量，应将患者和照顾者视为一个整体，通过降低病耻感改善双方整体生活质量。

To explore the mutual influence of stigma of ¹²⁵I implantation patients and their caregivers on their quality of life,and to provide a basis for the formulation of targeted nursing intervention strategies.

Using convenience sampling,80 pairs of patients undergoing ¹²⁵I seed implantation and their primary caregivers admitted to Jiangyin People's Hospital from January 2023 to January 2024 were selected as the research subjects. The Social Impact Scale (SIS) was used to assess the patients'stigma,the Associated Stigma Scale (ASS) to assess the caregivers'stigma,and the Short Form 12 (SF-12) to evaluate the quality of life of both groups.Pearson correlation analysis was conducted to test the correlation between variables,and the Actor-Partner Interdependence Model was established.The actor and partner effects were quantified through path analysis of the Actor-Partner Interdependence Model.

The score of stigma in patients after ¹²⁵I particle implantation (58.95 ± 12.38) was higher than that of caregivers (46.38 ± 7.93). The total scores of physical and psychological quality of life in patients (42.94 ± 10.33) and caregivers (49.15 ± 9.49) were lower, respectively. The differences were statistically significant (stigma: t=8.578, physical quality of life: t=-3.962, psychological quality of life: t=-5.555, all P<0.001). The stigma of patients was negatively correlated with their own physical quality of life (r=-0.733, P<0.001) and psychological quality of life (r=-0.660, P<0.001). The stigma of caregivers was also negatively correlated with their own physical quality of life (r=-0.563, P<0.001) and psychological quality of life (r=-0.448, P<0.001). The main effect: The stigma of patients (β=-0.808) and caregivers (β=-0.947) significantly negatively predicted their own physical health. The object effect: The stigma of caregivers had a significant negative predictive effect on the mental health of patients (β=-0.808, P<0.05), but the stigma of patients had no significant effect on the quality of life of caregivers (β=0.397, P=0.273; β=-0.655, P=0.092).

The stigma of patients undergoing ¹²⁵I seed implantation and their caregivers is at a relatively high level, with patients having a higher degree of stigma than their caregivers. Stigma affects the quality of life of patients and caregivers through the " actor-partner " dual path. Patients and caregivers should be regarded as a whole, and the overall quality of life of both should be improved by reducing stigma.