本文报道1例40岁女性中线癌患者，因胸痛、咳嗽等症状就诊，确诊时伴纵隔、肺转移，经单药化疗无效且症状加重，出现气管及上腔静脉受压表现。经多学科会诊后，先予CT引导下¹²⁵Ⅰ粒子植入术，术后局部肿瘤缩小但局部肺转移灶增大，遂行粒子补种联合支气管动脉灌注化疗栓塞术，后续同步安罗替尼靶向治疗与信迪利单抗免疫治疗。经6个月综合治疗，患者胸部肿瘤消失、淋巴结缩小，影像学评估为部分缓解，临床症状显著改善。本病例提示，介入局部治疗联合靶向及免疫的综合方案，可为无法手术、常规化疗无效的中线癌患者提供有效治疗思路，能快速缓解症状、提升疗效。

We present a case of a 40-year-old female patient with midline carcinoma, who was admitted for chest pain and cough and diagnosed with concurrent mediastinal and pulmonary metastases. Single-agent chemotherapy proved ineffective and her clinical symptoms aggravated, accompanied by tracheal and superior vena cava compression. Following multidisciplinary consultation, CT-guided ¹²⁵Ⅰ seed implantation was initially performed. Local tumors regressed postoperatively while partial pulmonary metastatic lesions progressed, prompting seed reimplantation combined with bronchial arterial chemoembolization, followed by concurrent anlotinib targeted therapy and sintilimab immunotherapy. After six months of comprehensive treatment, the thoracic tumors resolved, lymph nodes shrank, radiological evaluation indicated partial response, and the patient's clinical symptoms were significantly relieved. This case demonstrates that the integrated regimen of interventional local therapy plus targeted and immunotherapy offers a viable therapeutic approach for inoperable midline carcinoma patients with refractory conventional chemotherapy, enabling rapid symptom relief and improved treatment efficacy.