颈椎病是一种常见病，多发病，随着生活方式的改变、不良姿势的影响，发病率呈上升趋势，目前主要的微创治疗方式包括射频消融、激光消融、胶原酶溶解等技术。胶原酶作为远期效果肯定的一种治疗方式，如何让更多的药液抵达靶点一直是临床工作的难点。本文回顾性分析6例前入路胶原酶硬膜外前间隙注射技术，直接作用于突出的髓核表面，能够更好地让药液抵达靶点，为临床上颈椎病的治疗提供新的思路。

回顾性分析2024年8月至2024年9月陕西省第二人民医院椎间盘微创介入科共6例颈椎病患者前入路胶原酶硬膜外前间隙注射技术的临床经验，总结技术要点。

6例患者均成功完成手术，术后无明显恶心、呕吐、头痛、头晕等不适，无出血、药物进入蛛网膜下腔等严重并发症发生，术后患者症状较前缓解顺利出院。

前入路胶原酶硬膜外前间隙注射技术是一种可行、安全、可靠的治疗颈椎病的技术。

Cervical spondylosis is a common and frequently occurring disease. With lifestyle changes and poor posture, its incidence is on the rise. Currently, the main minimally invasive treatment methods include radiofrequency ablation, laser ablation, collagenase lysis, and other technologies. Among these, collagenase has demonstrated positive long-term effects. However, ensuring that a sufficient amount of the drug solution reaches the target site remains a clinical challenge. This paper presents a retrospective analysis of six cases using an anterior approach for collagenase injection into the anterior epidural space, directly targeting the protruding surface of the nucleus pulposus. This technique may enhance drug delivery to the lesion and provide a new therapeutic option for the treatment of cervical spondylosis.

The clinical experience of the anterior approach for targeted collagenase injection into cervical discs was retrospectively analyzed in six patients treated at the Department of Minimally Invasive Intervertebral Disc Intervention, Shaanxi Second People's Hospital, from August 2024 to September 2024. The key technical points of the procedure were summarized.

All six patients were successfully discharged after the procedure. No postoperative complications such as nausea, vomiting, headache, or dizziness occurred, and no severe adverse events such as bleeding or inadvertent drug entry into the subarachnoid space were observed.

The anterior approach of collagenase injection into the anterior epidural space appears to be a feasible, safe, and reliable technique for the treatment of cervical spondylosis.