评估局部硬化剂注射治疗化脓性肉芽肿的安全性和疗效。

回顾性分析2022年2月至2024年12月，广州医科大学附属广州市妇女儿童医疗中心介入血管瘤科收治的化脓性肉芽肿患者的临床资料，根据肿物外观并参考其基底部尺寸，分为宽蒂型与窄蒂型，其中宽蒂型采用丝线结扎联合硬化剂注射，窄蒂型仅使用硬化剂注射，分析患者的治疗结果、并发症发生率、治疗次数以及复发情况，评估治疗的临床效果。

在15例患者中，共有9例窄蒂型接受了硬化剂注射，6例宽蒂型接受了丝线结扎联合硬化剂（1%聚多卡醇或聚桂醇）注射的联合治疗，所有病变在治疗后的8周内完全消退，1例患者接受了2次局部注射，其余患者仅接受一次注射。所有患者治疗过程耐受性良好，未见过敏反应和皮肤坏死等不良反应。随访时间2~24个月，未见肿物复发，愈合后无色素沉着或疤痕形成。

局部硬化注射是治疗化脓性肉芽肿的高效且安全的治疗方法，对于宽蒂型病例，结合结扎方法可提高疗效。

This study aimed to evaluate the safety and efficacy of local sclerosant injection in the treatment of pyogenic granuloma.

A retrospective analysis was performed on patients with pyogenic granuloma admitted to the Interventional Vascular Anomalies Department of our hospital from February 2022 to December 2024. Based on the appearance of the lesion and its basal dimensions, patients were classified into broad-stalk and narrow-stalk types. The broad-stalk type was treated with a combination of ligation using silk thread and injection of a sclerosant, whereas the narrow-stalk type received only the sclerosant injection. Treatment outcomes, incidence of complications, number of treatment sessions, and recurrence rates were analyzed to assess the clinical effectiveness of the treatment.

Among the 15 patients included, 9 with the narrow-stalk type underwent sclerosant injection, and 6 with the broad-stalk type received the combined treatment of silk thread ligation and injection of a sclerosant (either 1% polidocanol or Lauromacrogol). Complete resolution of the lesions was achieved within 8 weeks following treatment. Only 1 patient required 2 sessions of local injection, while the remaining patients were successfully treated with a single session. All patients tolerated the treatment well, and no adverse reactions such as allergic responses or skin necrosis were observed. During a follow-up period ranging from 2 to 24 months, no recurrences were noted, and no post-healing pigment deposition or scar formation was observed.

Local sclerosant injection is a highly effective and safe treatment modality for pyogenic granuloma. For broad-stalk lesions, the addition of ligation may further enhance therapeutic outcomes.