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中华介入放射学电子杂志 ›› 2021, Vol. 09 ›› Issue (01) : 41 -44. doi: 10.3877/cma.j.issn.2095-5782.2021.01.007

所属专题: 文献

血管介入

聚多卡醇泡沫硬化治疗儿童Puig'sⅠ型和Ⅱ型肛周静脉畸形临床研究
左松1, 董长宪1,(), 肖莉1, 王彦林1, 郭晓楠1, 任腾飞1   
  1. 1. 450003 河南郑州,河南省人民医院血管瘤科,郑州大学人民医院
  • 收稿日期:2020-09-22 出版日期:2021-02-25
  • 通信作者: 董长宪

Clinical study on sclerotherapy with polidocanol injectable foam in treatment of Puig's Ⅰ and Ⅱ perianal venous malformations in children

Song Zuo1, Changxian Dong1,(), Li Xiao1, Yanlin Wang1, Xiaonan Guo1, Tengfei Ren1   

  1. 1. Department of Hemangioma and Vascular Malformation, Henan Provincial People's Hospital; People's Hospital of Zhengzhou University, Henan Zhengzhou 450003, China.
  • Received:2020-09-22 Published:2021-02-25
  • Corresponding author: Changxian Dong
引用本文:

左松, 董长宪, 肖莉, 王彦林, 郭晓楠, 任腾飞. 聚多卡醇泡沫硬化治疗儿童Puig'sⅠ型和Ⅱ型肛周静脉畸形临床研究[J/OL]. 中华介入放射学电子杂志, 2021, 09(01): 41-44.

Song Zuo, Changxian Dong, Li Xiao, Yanlin Wang, Xiaonan Guo, Tengfei Ren. Clinical study on sclerotherapy with polidocanol injectable foam in treatment of Puig's Ⅰ and Ⅱ perianal venous malformations in children[J/OL]. Chinese Journal of Interventional Radiology(Electronic Edition), 2021, 09(01): 41-44.

目的

探讨DSA引导下聚多卡醇泡沫硬化治疗儿童Puig'Ⅰ型和Ⅱ型肛周静脉畸形的临床疗效。

方法

回顾性分析2018年3月至2019年6月就诊于我科的38例Puig'sⅠ型和Ⅱ型肛周静脉畸形患儿,采用全麻下DSA引导经皮多点穿刺3%聚多卡醇泡沫硬化治疗,术后观察疗效、不良反应,术后随访14~28个月。

结果

38例患儿共治疗76次(1~3次/例),治愈28例,基本治愈9例,有效1例;治愈率73.68%(28/38),总有效率为100%。3%聚多卡醇泡沫硬化剂平均单次应用剂量为(5.94±1.69)mL。不良反应:76例次介入硬化治疗术后均有轻度肿胀,3例次肛周静脉畸形皮肤张力性水泡。皮肤轻度溃烂1例,对症治疗10 d后皮肤愈合。

结论

3%聚多卡醇泡沫硬化治疗儿童Puig'sⅠ型和Ⅱ型肛周静脉畸形是一种微创、安全、有效且值得推广的治疗方法。

Objective

To evaluate the clinical efficacy of DSA-guided sclerotherapy with polidocanol injectable foam in treatment of Puig's Ⅰ and Ⅱ perianal venous malformations in children.

Methods

A retrospective analysis was made of 38 children with Puig's Ⅰ and Ⅱ perianal venous malformations who were treated with DSA-guided percutaneous puncture of 3% polydocarol foam sclerotherapy under general anesthesia from March 2018 to June 2019 in Henan Provincial People's hospital.The curative effect, adverse reactions were observed in follow-up.

Results

The 38 children were treated 76 times (1-3 times/case), and the average single application dose of 3% polydocarol foam sclerosant was (5.94±1.69) mL. 28 cases were cured, 9 cases were basically cured and 1 case was effective; the cure rate was 73.68% (28/38), and the total effective rate was 100%. Adverse reactions. There were mild swelling at the lesion in 76 cases after interventional sclerotherapy and tension blisters in the skin in 3 cases.One patient had mild skin ulceration, however, the ulcertion healed after 10 days of symptomatic treatment. After 14-28 months of follow-up (median follow-up time was 24 months), there was no significant recurrence of symptoms.

Conclusions

3% polydocanol foam sclerotherapy is a minimally invasive, safe, effective and worth popularization treatment for Puig's Ⅰ and Ⅱ perianal venous malformations in children.

图1 经皮穿刺静脉造影示Puig'sⅡ型VM
图2 在路径图模式下注入3%聚多卡醇泡沫硬化剂,清晰显示泡沫硬化剂为负性显影
图3 MRI示肛周皮肤、皮下T2WI高信号
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