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中华介入放射学电子杂志

中华介入放射学电子杂志 ›› 2021, Vol. 09 ›› Issue (03) : 331 -335,344. doi: 10.3877/cma.j.issn.2095-5782.2021.03.016

综述

外科切除与微波消融对非小细胞肺癌治疗的应用比较
訾洋1, 韦伟2, 杨泽军2, 王曼璐2, 贾广志2, 秦孝军2, 关利君2,†()   
  1. 1. 010000　内蒙古呼和浩特，内蒙古医科大学第一临床医学院
    2. 010000　内蒙古呼和浩特，内蒙古医科大学附属医院介入科
  • 收稿日期:2021-01-03 出版日期:2021-08-25
  • 通信作者: 关利君

Comparison of Surgical resection and Microwave Ablation in the treatment of Nonsmallcell Lung Cancer

Yang Zi1, Wei Wei2, Zejun Yang2, Manlu Wang2, Guangzhi Jia2, Xiaojun Qin2, Lijun Guan2,†()   

  1. 1. First Clinical Medical College, Inner Mongolia Medical University
    2. Department of Intervention, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Hohhot 010000, China
  • Received:2021-01-03 Published:2021-08-25
  • Corresponding author: Lijun Guan
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訾洋, 韦伟, 杨泽军, 王曼璐, 贾广志, 秦孝军, 关利君. 外科切除与微波消融对非小细胞肺癌治疗的应用比较[J]. 中华介入放射学电子杂志, 2021, 09(03): 331-335,344.

Yang Zi, Wei Wei, Zejun Yang, Manlu Wang, Guangzhi Jia, Xiaojun Qin, Lijun Guan. Comparison of Surgical resection and Microwave Ablation in the treatment of Nonsmallcell Lung Cancer[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2021, 09(03): 331-335,344.

肺癌是全世界最常见的恶性肿瘤之一，也是目前我国恶性肿瘤的首位死亡原因。其中，非小细胞肺癌占80%以上。截至目前，外科手术仍是非小细胞肺癌的首要治疗手段。但是大部分患者因为心肺功能较差、肿瘤已进入晚期或拒绝手术而不能行外科切除。因此，不少学者开始寻找新的治疗手段，解决当前出现的问题。近些年微波消融（MWA）因为适用范围广、效果好、并发症少等特点吸引了人们的注意，逐渐成为了部分肺癌患者的可靠治疗方法。而对于肺癌的治疗，如何取舍外科切除和MWA一直困扰着世界各国学者。文章对外科切除与MWA在肺癌中的应用进行综述比较，为肺癌治疗的选择提供参考。

关键词: 肺癌, 微波消融, 外科切除

Lung cancer is one of the most common malignant tumors in the world, and also the first cause of death of malignant tumors in China. Nonsmall cell lung cancer (NSCLC) accounts for more than 80% of all lung cancer cases. Up to now, surgery is still the primary treatment for Nonsmallcell lung cancer. However, most patients can not undergo surgical resection because of poor cardiopulmonary function, advanced tumor or refusal of surgery. Therefore, many scholars began to look for new treatment methods to solve the current problems. In recent years, microwave ablation (MWA) has attracted people's attention because of its wide application range, good effect and fewer complications. And it also solves some short plates of surgical resection. For the treatment of lung cancer, how to choose between surgical resection and MWA has been puzzling scholars all over the world. This article would like to review and compare surgical resection and MWA in the application of lung cancer to provide a reference for the selection of treatment of lung cancer.

Key words: Lung cancer, Microwave ablation, Surgical resection
[1]
Altorki NK, Markowitz GJ, Gao D, et al. The lung microenvironment: an important regulator of tumour growth and metastasis[J]. Nat Rev Cancer, 2019, 19(1): 9-31.
[2]
Ye X, Fan W, Wang H, et al. Expert consensus workshop report: Guidelines for thermal ablation of primary and metastatic lung tumors (2018 edition)[J]. J Cancer Res Ther, 2018, 14(4): 730-744.
[3]
中华人民共和国国家卫生健康委员会. 原发性肺癌诊疗规范(2018年版)[J]. 肿瘤综合治疗电子杂志, 2019, 5(3): 100-120.
[4]
何建行，刘会平，杨运有. 电视胸腔镜肺癌根治术5年临床疗效[J]. 中国胸心血管外科临床杂志, 2002(1): 29-31.
[5]
王珏，郭占领. Ⅰ期至ⅢA期肺癌外科规范化治疗的研究进展[J]. 中国胸心血管外科临床杂志, 2014, 21(5): 675-680.
[6]
Ginsberg RJ, Rubinstein LV. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group[J]. Ann Thorac Surg, 1995, 60(3):615-622.
[7]
支修益，李辉，陈东红. 早期非小细胞肺癌外科治疗进展[J]. 肿瘤研究与临床, 2010(1): 2-6.
[8]
于占武，刘顺寿，玉寒冰, 等. 外科治疗老年肺癌40例的临床分析[J]. 辽宁中医药大学学报, 2009, 11(2): 126-127.
[9]
Zhong L, Sun S, Shi J, et al. Clinical analysis on 113 patients with lung cancer treated by percutaneous CT-guided microwave ablation[J]. J Thorac Dis, 2017, 9(3): 590-597.
[10]
Vogl TJ, Nour-Eldin NA, Albrecht MH, et al. Thermal ablation of lung tumors: focus on microwave ablation[J]. Rofo, 2017, 189(9): 828-843.
[11]
Song D, Yu F, Chen S, et al. Raman spectroscopy combined with multivariate analysis to study the biochemical mechanism of lung cancer microwave ablation[J]. Biomed Opt Express, 2020, 11(2): 1061-1072.
[12]
Han X, Yang X, Huang G, et al. Safety and clinical outcomes of computed tomography-guided percutaneous microwave ablation in patients aged 80 years and older with early-stage non-small cell lung cancer: A multicenter retrospective study[J]. Thorac Cancer, 2019, 10(12): 2236-2242.
[13]
Wei Z, Ye X, Yang X, et al. Microwave ablation in combination with chemotherapy for the treatment of advanced non-small cell lung cancer[J]. Cardiovasc Intervent Radiol, 2015, 38(1):135-142.
[14]
Zhang YQ, Wu YL, Feng Y, et al. A clinical study on microwave ablation in combination with chemotherapy in treating peripheral IIIB-IV nonsmall cell lung cancer[J]. Cancer Biother Radiopharm, 2020. DOI: 10.1089/cbr.2020.3859. Online ahead of print.
[15]
Das SK, Huang YY, Li B, et al. Comparing cryoablation and microwave ablation for the treatment of patients with stage IIIB/IV non-small cell lung cancer[J]. Oncol Lett, 2020, 19(1):1031-1041.
[16]
周京旭，李虹，吕文姣, 等. 经皮射频消融联合化疗治疗Ⅲb~Ⅳ期非小细胞肺癌的疗效[J]. 实用医学杂志, 2015, 31(11): 1786-1789.
[17]
Tafti BA, Genshaft S, Suh R, et al. Lung ablation: indications and techniques[J]. Semin Intervent Radiol, 2019, 36(3): 163-175.
[18]
Yao W, Lu M, Fan W, et al. Comparison between microwave ablation and lobectomy for stage I non-small cell lung cancer: a propensity score analysis[J]. Int J Hyperthermia, 2018, 34(8): 1329-1336.
[19]
Wang Y, Liu B, Cao P, et al. Comparison between computed tomography-guided percutaneous microwave ablation and thoracoscopic lobectomy for stage I non-small cell lung cancer[J]. Thorac Cancer, 2018, 9(11): 1376-1382.
[20]
Watanabe SI, Nakagawa K, Suzuki K, et al. Neoadjuvant and adjuvant therapy for Stage III non-small cell lung cancer[J]. Jpn J Clin Oncol, 2017, 47(12): 1112-1118.
[21]
Shumway D, Corbin K, Salgia R, et al. Pathologic response rates following definitive dose image-guided chemoradiotherapy and resection for locally advanced non-small cell lung cancer[J]. Lung Cancer, 2011, 74(3): 446-450.
[22]
Romero-Vielva L, Viteti S, Moya-Horno I, et al. Salvage surgery after definitive chemo-radiotherapy for patients with Non-Small Cell Lung Cancer[J]. Lung Cancer, 2019, 133: 117-122.
[23]
高云姝，李露嘉，李翊, 等. 微波消融序贯化疗治疗晚期非小细胞肺癌的免疫学效应观察[J]. 中华肺部疾病杂志(电子版), 2013, 6(6): 518-520.
[24]
Wei Z, Ye X, Yang X, et al. Microwave ablation in combination with chemotherapy for the treatment of advanced non-small cell lung cancer[J]. Cardiovasc Intervent Radiol, 2015, 38(1): 135-142.
[25]
何春雷，孙京涛，刘爱兰, 等. CT引导水冷循环微波消融联合放化疗治疗Ⅲ期周围型肺癌的临床疗效探究[J]. 医疗装备, 2016, 29(2): 2-3.
[26]
De Groot PM, Shroff GS, Carter BW, et al. Lung cancer: postoperative imaging and complications[J]. J Thorac Imaging, 2017, 32(5): 276-287.
[27]
王瞻，许林锋. 肺癌微波消融治疗进展[J]. 临床放射学杂志, 2014, 33(7): 1105-1107.
[28]
田慧，叶欣. 微波消融治疗早期非小细胞肺癌现状[J]. 介入放射学杂志, 2018, 27(11): 1102-1106.
[29]
叶欣，范卫君，王徽, 等. 热消融治疗原发性和转移性肺部肿瘤专家共识(2017年版)[J]. 中国肺癌杂志, 2017, 20(7): 433-445.
[30]
Songping , Cui , Hui . [Perioperative venous thromboembolism (VTE) prophylaxis in thoracic cancer patients: Chinese Experts Consensus - Interpretation of Perioperative Hypercoagulable State[J]. Chinese Journal of Lung Cancer, 2019, 22(12): 752-756.
[31]
Sanchez-Lorente D, Navarro-Ripoll R, Guzman R, et al. Prehabilitation in thoracic surgery[J]. J Thorac Dis, 2018, 10 (Suppl 22): S2593-S2600.
[32]
Tokunaga Y, Kita Y, Okamoto T. Analysis of risk factors for bronchopleural fistula after surgical treatment of lung cancer[J]. Ann Thorac Cardiovasc Surg, 2020, 26(6): 311-319.
[33]
Dai L, Kang X, Yan W, et al. Analysis of prolonged hospitalizations (longer than 7 days): 115 lung cancer patients after video assistant thoracic surgery (VATS)[J]. Zhongguo Fei Ai Za Zhi, 2018, 21(3): 223-229.
[34]
Li Z, Yu Y, Lu J, et al. Analysis of the T descriptors and other prognosis factors in pathologic stage I non-small cell lung cancer in China[J]. J Thorac Oncol, 2009, 4(6): 702-709.
[35]
刘文科，张林，张曙光. ⅠA期非小细胞肺癌患者肺叶切除术及肺叶部分切除术的生存分析[J]. 中国胸心血管外科临床杂志, 2017, 24(10): 768-773.
[36]
Li Y, Bie F, Wang Y, et al. Prognostic effect of a risk index model in postoperative non-small-cell lung cancer patients[J]. Future Oncol, 2019, 15(24): 2829-2840.
[37]
Wolf FJ, Grand DJ, Machan JT, et al. Microwave ablation of lung malignancies: effectiveness, CT findings, and safety in50 patients[J]. Radiology, 2008, 247(3): 871-879.
[38]
Yang X, Ye X, Zheng A, et al. Percutaneous microwave ablation of stage I medically inoperable non-small cell lung cancer: clinical evaluation of 47 cases[J]. J Surg Oncol, 2014, 110(6): 758-763.
[39]
陆运，薛涛，胡若愚, 等. 肺腺癌淋巴结转移危险因素的回顾性研究[J]. 东南大学学报(医学版), 2019, 38(3): 505-510.
[40]
姚源山，华青旺，沈海波. Ⅰ期非小细胞肺癌术后的预后分析[J]. 中国肿瘤外科杂志, 2019, 11(1): 36-40.
[41]
Decaluwe H, Petersen RH, Brunelli A, et al. Multicentric evaluation of the impact of central tumour location when comparing rates of N1 upstaging in patients undergoing video-assisted and open surgery for clinical Stage I non-small-cell lung cancerdagger[J]. Eur J Cardiothorac Surg, 2018, 53(2): 359-365.
[42]
阚奇伟，刘伦旭. 肺癌手术中淋巴结清扫的现状与进展[J].中国胸心血管外科临床杂志, 2009, 16(3): 214-217.
[43]
汪天虎. 中央型肺癌的微创治疗[J]. 临床外科杂志, 2018, 26(3): 168-170.
[44]
方文涛，陈瑭冰，罗继壮, 等. 微创外科技术在中央型肺癌治疗中的应用[J]. 中华外科杂志, 2020(1): 57-58.
[45]
Li Z, Chen W, Xia M, et al. Sleeve lobectomy compared with pneumonectomy for operable centrally located non-small cell lung cancer: a meta-analysis[J]. Transl Lung Cancer Res, 2019, 8(6): 775-786.
[46]
闵伟伟，张建斌，李鸿伟, 等. 全胸腔镜肺叶切除治疗早期中央型肺癌的回顾性分析[J]. 实用肿瘤杂志, 2019, 34(6):529-533.
[47]
Xie D, Deng J, Gonzalez-Rivas D, et al. Comparison of video-assisted thoracoscopic surgery with thoracotomy in bronchial sleeve lobectomy for centrally located non-small cell lung cancer[J]. J Thorac Cardiovasc Surg, 2021, 161(2): 403-413.
[48]
汪超，张本华. 微波消融在肺癌治疗中的研究新进展[J]. 泰山医学院学报, 2018, 39(9): 1077-1080.
[49]
郭亚，孙亚红，宋鹏远, 等. CT引导经皮穿刺微波消融肺部恶性肿瘤的临床观察[J]. 临床肿瘤学杂志, 2013, 18(7): 640-643.
[50]
Yuan HB, Wang XY, Sun JY, et al. Flexible bronchoscopy-guided microwave ablation in peripheral porcine lung: a new minimally-invasive ablation[J]. Transl Lung Cancer Res, 2019, 8(6): 787-796.
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