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中华介入放射学电子杂志 ›› 2020, Vol. 08 ›› Issue (04) : 364 -369. doi: 10.3877/cma.j.issn.2095-5782.2020.04.014

所属专题: 文献

综述

载药栓塞材料在肝癌治疗中的应用
石钦1, 周晨1, 刘家成1, 黄松江1, 杨崇图1, 熊斌1,()   
  1. 1. 430022 湖北武汉,华中科技大学同济医学院附属协和医院放射科,分子影像湖北省重点实验室
  • 收稿日期:2020-07-02 出版日期:2020-11-25
  • 通信作者: 熊斌
  • 基金资助:
    国家自然科学基金(81873917)

Application of drug-loaded embolic agents in the treatment of hepatocellular carcinoma

Qin Shi1, Chen Zhou1, Jiacheng Liu1, Songjiang Huang1, Chongtu Yang1, Bin Xiong1,()   

  1. 1. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Province Key Laboratory of Molecular Imaging, Hubei Wuhan 430022, China
  • Received:2020-07-02 Published:2020-11-25
  • Corresponding author: Bin Xiong
  • About author:
    Corresponding author: Xiong Bin, Email:
引用本文:

石钦, 周晨, 刘家成, 黄松江, 杨崇图, 熊斌. 载药栓塞材料在肝癌治疗中的应用[J/OL]. 中华介入放射学电子杂志, 2020, 08(04): 364-369.

Qin Shi, Chen Zhou, Jiacheng Liu, Songjiang Huang, Chongtu Yang, Bin Xiong. Application of drug-loaded embolic agents in the treatment of hepatocellular carcinoma[J/OL]. Chinese Journal of Interventional Radiology(Electronic Edition), 2020, 08(04): 364-369.

原发性肝癌是全球最常见的恶性肿瘤之一,其发病率和死亡率均居前列。肝动脉化疗栓塞(transarterial chemoembolization,TACE)是中晚期肝癌的首选治疗手段,通过将栓塞剂和化疗药物混合靶向递送至肿瘤区域,实现局部缺血坏死的同时减少药物全身副作用。其中,栓塞材料在TACE抗肝癌的功效中起着至关重要的作用。目前,已有多种栓塞材料通过不同的载药机制与化疗药物结合,并应用于肝癌治疗。本文就目前研发的载药栓塞材料在肝癌中的应用作一综述。

Primary liver cancer is one of the most common malignant tumors in the world with high morbidity and mortality. Transarterial chemoembolization (TACE) is the preferred treatment for advanced liver cancer. It can cause tumor ischemic necrosis while reducing systemic adverse events through the targeted delivery of embolic agent and chemotherapy drug. The embolic agent plays a crucial role in the treatment of liver cancer. At present, many embolic agents can be combined with chemotherapy drugs through various drug-loaded mechanisms, and they are further applied in the treatment of liver cancer. This article reviews the application of drug-loaded embolic agents in the treatment of liver cancer.

表1 有关DEB的载药机制及在肝癌中的应用
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