通过支架置入的成功率及生物相容性的实验动物研究，对肺动脉支架置入的可行性进行评价。

成年杂种犬8只，随机分为2组，每组4只。全麻下采用介入技术在其右肺下叶动脉置入Cook Zliver 635自膨式血管支架。实验组1术前2天～术后12周使用抗凝药，实验组2术前2天～术后6周使用抗凝药。所有动物，术前及术后即刻、术后6周、12周行DSA检查；术后6周、12周行CT肺动脉造影；术前及术后6周、12周进行肺动脉压力、潮气量及血气分析测定，12周时将动物处死取标本。评价支架置入过程、术后影像学表现、标本的组织病理学改变，对技术成功率、支架内皮覆盖、支架置入后狭窄率和潮气量、血气分析等参数进行统计学处理。采用SPSS 13. 0软件包进行分析，测最数据采用配对t检验及Friedman检验方法进行分析。

8只实验动物均顺利置入血管支架于右肺动脉内，支架释放过程顺利，支架膨胀良好、位置满意。术后影像学检查8只动物支架均未见狭窄、移位、变形、断裂等改变，但CT肺动脉造影显示其中2例支架近端未能完全贴紧血管壁。肺动脉压、潮气量、血气分析检查未发现显著改变。4例支架完全内皮化，4例支架未能完全内皮化(所有未完全内皮化的支架皆为远端内皮化，近端未内皮化，1例内皮化约30%、2例内皮化约50%、1例内皮化约70%)，支架远端较近端更易形成内皮化，内皮化程度与实验组无关。被支架覆盖开口的分支血管皆未堵塞，血管内皮绕过血管分支开口处生长。

自膨式血管支架可以顺利置入犬肺动脉，对呼吸功能、右心功能无显著影响。肺动脉的血管支架置入是安全可行的。

To evaluate the feasibility of the pulmonary artery stenting through the animal experimental study of stenting success rate and biocompatibility.

Eight adult mongrel dogs were randomly divided into two groups (each four). Cook Zliver 635 self-expanding stents have been placed into the pulmonary artery in their right lower lungs using interventional techniques under general anesthesia. Experimental group 1 took anticoagulants in a period spanning from 2 days before the operation to 12 weeks after it, while experimental group 2 took anticoagulants in a period spanning from 2 days before operation to 6 weeks after it. All the animals underwent DSA examination before and immediately after operation, after 6 weeks and 12 weeks; 6 weeks and 12 weeks after operation, they underwent CT pulmonary angiography; pulmonary artery pressure, tidal volume and blood gas analysis were checked 6 weeks and 12 weeks before and after operation. The animals were sacrificed 12 weeks after operation, and specimens were taken. Stenting procedure, postoperative imaging, histopathology specimens were evaluated through statistics on technical success rate, frame endothelial coverage rate, tidal volume, stenosis rate after stenting, blood gas analysis and other parameters. Data were analyzed with paired t test and the Friedman test using SPSS 13.0 software package.

Pulmonary vascular stents were successfully placed in the right lungs of all the eight animals. Stenting was smoothly operated, with a successful stent expansion and a well-satisfied position. Postoperative imaging of the 8 animals showed no stent stenosis, displacement, deformation, fracture or other changes, but the CT pulmonary angiography showed 2 cases of proximal stent not fully attached to the vessel wall. Inspection on pulmonary artery pressure, tidal volume and blood gas analysis found no significant change. Four cases of stent were completely endothelialized, but another 8 not all of them were distal endothelialization, instead of proximal; 1 was about 30% endothelialized, 2 about 50%, and the other 1 about 70%. Endothelialization was more easily found at the distal end than at the proximal end. Endothelization was not clearly distinguished between those 2 groups. The branch vessels covered by the stent were not clogged. Endothelium grew round blood vessel branches.

Self-expanding stents could be successfully placed in the pulmonary artery of dogs, which has no significant effect on respiratory function or right ventricular function. Pulmonary vascular stenting is safe and feasible.