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中华介入放射学电子杂志 ›› 2013, Vol. 01 ›› Issue (01) : 27 -31. doi: 10.3877/cma.j.issn.2095-5782.2013.01.008

南京医科大学附属南京医院介入科;南京医科大学附属南京医院妇科

Glubran-2胶栓塞卵巢静脉治疗盆腔淤血综合征
苏浩波1, 顾建平1,(), 楼文胜1, 何旭1, 谢静燕2, 陈亮1, 陈国平1, 宋进华1, 施万印1, 汪涛1, 赵伯翔1   
  1. 1.210006 南京医科大学附属南京医院介入科
    2.210006 南京医科大学附属南京医院妇科
  • 收稿日期:2013-06-20 出版日期:2013-08-01
  • 通信作者: 顾建平

Transcatheter ovarian vein embolization using Glubran-2 acrylic glue for the treatment of pelvic congestion syndrome

Hao-bo SU1, Jian-ping GU1,(), Wen-sheng LOU1, Xu HE1, Jing-yan XIE1, Liang CHEN1, Guo-ping CHEN1, Jin-hua SONG1, Wan-yin SHI1, Tao WANG1, Bo-xiang ZHAO1   

  1. 1.Department of Interventional Radiology,Nanjing Hospital Affiliated to Nanjing Medical University,Nanjing 210006,China
  • Received:2013-06-20 Published:2013-08-01
  • Corresponding author: Jian-ping GU
引用本文:

苏浩波, 顾建平, 楼文胜, 何旭, 谢静燕, 陈亮, 陈国平, 宋进华, 施万印, 汪涛, 赵伯翔. Glubran-2胶栓塞卵巢静脉治疗盆腔淤血综合征[J]. 中华介入放射学电子杂志, 2013, 01(01): 27-31.

Hao-bo SU, Jian-ping GU, Wen-sheng LOU, Xu HE, Jing-yan XIE, Liang CHEN, Guo-ping CHEN, Jin-hua SONG, Wan-yin SHI, Tao WANG, Bo-xiang ZHAO. Transcatheter ovarian vein embolization using Glubran-2 acrylic glue for the treatment of pelvic congestion syndrome[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2013, 01(01): 27-31.

目的

探讨Glubran-2胶栓塞卵巢静脉治疗盆腔淤血综合征(pelvic congestion syndrome,PCS)的临床疗效及应用价值。

方法

2009年1月至2012年6月,采用Glubran-2胶对12例PCS患者(年龄36~65岁,中位年龄45.2岁)进行卵巢静脉栓塞治疗。临床疗效观察以问卷方式采集,了解患者术前及术后1、3、6和12个月盆腔疼痛症状改善程度,以及有无手术相关的不适症状、并发症等。疼痛症状改善程度用视觉模拟评分法(VAS)进行评估分析。治疗前后疼痛评分比较采用配对t检验

结果

应用Glubran-2胶栓塞卵巢静脉技术成功率100%,无并发症发生。12例患者中术后问卷调查达到治愈3例(25.0%),好转8例(66.7%),总有效率91.7%;无效1例(8.3%)。随访VAS评分调查显示栓塞术后慢性盆腔疼痛程度评分显著改善[术前(6.4±1.8)分,术后12个月随访(1.8±2.2)分,P<0.05]。

结论

应用Glubran-2胶进行PCS的介入治疗是安全、有效的。

Objective

To evaluate the therapeutic effectiveness of ovarian vein embolization using Glubran-2 acrylic glue for pelvic congestion syndrome(PCS).

Methods

Between January 2009 and June 2012,12 patients(mean age,45.2years;range,36—65 years)were diagnosed with PCS and underwent ovarian vein Glubran-2 acrylic glue embolization.Follow-up was performed by physical examination and a questionnaire-based assessment of pain at 1,3,6,and 12 months after the procedure.In addition,in those cases where pain persisted after embolization or where patients were dissatisfied with the procedure,additional treatments and subsequent changes in pain scores were also analyzed by visual analogue scale(VAS).

Results

Technical success was achieved in all patients(100%)with no complications.Among a total of 12 patients,91.7%(11/12)were observed a statistically significant improvement in each category of specific symptoms at 1,3,6,and 12 months after the procedure.1 patients(8.3%,1/12)responded that the pain level had not changed.Pain score(VAS)was 6.4±1.8 pre-procedural versus 1.8±2.2 at the end of follow-up(P<0.05).

Conclusion

Ovarian vein embolization using Glubran-2 acrylic glue is a safe and effective therapeutic method for treatment of PCS.

表1 12例盆腔淤血综合征患者静脉栓塞术前症状分级与术后6个月疗效分布(例数)
表2 盆腔淤血综合征患者静脉栓塞术前与术后不同时间慢性盆腔疼痛视觉模拟(VAS)评分比较
1
Tu FF,Hahn D,Steege JF.Pelvic congestion syndrome-associated pelvic pain:a systematic review of diagnosis and management.Obstet Gynecol Surv,2010,65(5):332-340.
2
Liddle AD,Davies AH.Pelvic congestion syndrome:chronic pelvic pain causedby ovarian and internal iliac varices.Phlebology,2007,22(3):100-104.
3
Lechter A,Lopez G,Martinez C,et al.Anatomy of the gonadal veins:a reappraisal.Surgery,1991,109(6):735-739.
4
马水清,任芸静,郎景和.盆腔淤血综合征的临床研究进展.国外医学妇产科学分册,2004,31(3):167-170.
5
Edwards RD,Robertson IR,MacLean AB,et al.Case report:pelvic pain syndrom—successful treatment of a case by ovarian vein embolisation.Clin Radiol,1993,47(6):429-431.
6
Freedman J,Ganeshan A,Crowe PM.Pelvic congestion syndrome:the role ofinterventional radiology in the treatment of chronic pelvic pain.Postgrad Med J,2010,86(1022):704-710.
7
Kies DD,Kim HS.Pelvic congestion syndrome:a review of current diagnostic and minimally invasive treatment modalities.Phlebology,2012,27(Suppl 1):52-57.
8
Venbrux AC,Chang AH,Kim HS,et al.Pelvic congestion syndrome(pelvic venous incompetence):impact of ovarian and internal iliac vein embolotherapy on menstrual cycle and chronic pelvic pain.J Vasc Interv Radiol,2002,13(2 Pt 1):171-178.
9
Gandini R,Chiocchi M,Konda D,et al.Transcatheter foam sclerotherapy of symptomatic female varicocele with sodium-tetradecyl-sulfate foam.Cardiovasc Intervent Radiol,2008,31(4):778-784.
10
Maleux G,Stockx L,Wilms G,et al.Ovarian vein embolization for the treatment of pelvic congestion syndrome:long-term technical and clinical results.J Vasc Interv Radiol,2000,11(7):859-864.
11
Tu FF,Hahn D,Steege JF.Pelvic congestion syndrome-associated pelvic pain:a systematic review of diagnosis and management.Obstet Gynecol Surv,2010,65(5):332-340.
12
van der Vleuten CJ,van Kempen JA,Schultze-Kool LJ.Embolization to treat pelvic congestion syndrome and vulval varicose veins.Int J Gynaecol Obstet,2012,118(3):227-230.
13
Raffi L,Simonetti L,Cenni P,et al.Use of Glubran-2 acrylic glue in interventional neuroradiology.Neuroradiology,2007,49(10):829-836.
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