To investigate the feasibility and safety of Intra-arterial chemotherapy via posterior communicating artery (p-IAC) for retinoblastoma (RB).

We retrospectively analyzed 4 patients diagnosed with retinoblastoma undergoing p-IAC. We recorded the data including gender, age, tumor staging, arteries approached, arteriography features and adverse events of p-IAC.

A total of 4 RB patients (2 boys, 2 girls) were included in this study. 3 children had RB in the right eye ( 2 eyes were stage D and 1 eye was stage E according to the International Intraocular Retinoblastoma Classification) and1 child has RB in the left eye (stage E). There were 5 procedures in all cases with excellent choroid staining by ophthalmography, and no embolism perfusion or obvious reflux. No catheter shedding was observed during the infusion of chemotherapy drugs, and no obvious adverse reactions were observed in the other 3 cases except eyelid swelling in 1 case.

p-IAC is safe and feasible in the treatment of RB, and can be attempt to children with difficulty in intubation due to ocular artery angle problems.