This study aims to retrieve, integrate, and evaluate the best evidence for hydration therapy in preventing contrast-induced nephropathy (CIN) after interventional procedures, providing an evidence-based foundation for the standardized prevention and management of CIN in clinical practice.

The PIPOST principle was followed to clearly define the evidence-based question. According to the "6S" evidence pyramid model, systematic searches were conducted in databases/websites such as BMJ Best Practice, UpToDate, JBI, PubMed, Web of Science, CNKI, VIP, Wanfang, the National Guideline Clearinghouse of the United States, the Scottish Intercollegiate Guidelines Network, the National Institute for Health and Care Excellence of the United Kingdom, and the Kidney Disease: Improving Global Outcomes. The search content focused on literature related to hydration therapy for preventing CIN in patients after interventional procedures. Data extraction and organization were carried out for the included literature, and a hierarchical evaluation was conducted.

A total of 15 articles were finally included, including 1 guideline, 1 expert consensus, 2 systematic reviews, 6 randomized controlled trials, and 5 quasi-experimental studies. A total of 18 recommendations covering four key dimensions, namely high-risk assessment, health education, implementation plans, and evaluation indicators, were integrated.

This study systematically analyzed the best practice evidence for hydration therapy in preventing post-interventional CIN, offering important scientific references for optimizing clinical decision-making and practice.