Abstract:
Objective To assess the effectiveness of traditional chinese medicine in the treament of post-ablation syndrome of hepatocarcinoma with the syndrome of liver stagnation and spleen deficiency, and analyze the changes in peripheral blood T cell subsets.
Methods This multicenter, randomized, double-blind, placebo-controlled trial enrolled 120 patients with primary liver cancer and a diagnosis of liver depression and spleen deficiency. Patients were randomly assigned to either the treatment group or the control group. The treatment group received minimally invasive therapy combined with Chinese medicine granules (major Bupleurum decoction combined with six gentlemen decoction with modifications), while the control group received minimally invasive therapy plus placebo.
Results Compared with the control group, patients in the treatment group showed significant improvement in the incidence and severity of post-ablation symptoms by day 5 after ablation (P<0.05). The length of hospital stay was also significantly shorter in the treatment group (P=0.001). Furthermore, immune function, reflected by changes in T-cell subsets, improved significantly in the treatment group compared with the control group (P<0.05).
Conclusion Traditional Chinese medicine aimed at regulating the liver and spleen can effectively alleviate post-ablation syndrome in HCC patients with liver depression and spleen deficiency, enhance recovery of immune function, and shorten hospitalization duration.
Key words:
liver stagnation and spleen deficiency syndrome liver cancer,
post-ablation syndrome,
Chinese medicine,
multicenter,
random
Jiang Long, Huaguang Wang, Chunwang Yuan, Qingsheng Fan, Shi Dong. Traditional Chinese Medicine for Regulating Liver and Spleen in the Treatment of Post-Ablation Syndrome for Primary Liver Cancer with Liver Depression and Spleen Deficiency[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2025, 13(04): 309-313.