To compare and analyze the value of breast tissue marker clip placement in X-ray evaluation of the effect of neoadjuvant chemotherapy and pathological examination of breast cancer.

From October 2022 to October 2023, 80 breast cancer patients undergoing neoadjuvant chemotherapy were selected from our hospital. They were divided into two groups based on whether a breast maker clip was placed: the marker clip group (n = 22) and the non-marker clip group (n = 58). The detection rates of primary breast lesions through X-ray re-examination, the coincident rate of X-ray evaluation and pathology evaluation after neoadjuvant chemotherapy, and the time-consuming of sending specimens to pathology after operation were compared between the two groups.

After the completion of neoadjuvant chemotherapy, the detection rate of primary breast lesions was 100% (22/22) in the marker clip group and 56.9% (33/58) in the non-marker clip group, there was significant difference between the two groups (P < 0.05). In the therapeutic effect of evaluated at X-ray, the sensitivity, specificity, positive predictive value, negative predictive value and assess compliance rate of the marker clip group were higher than those of the non-marker clip group; In the assessment of residual disease, the sensitivity, specificity, positive predictive value and assess compliance rate of the marker clip group were higher, and the negative predictive value was lower than those in the non-marker clip group. There was a significant difference between the two groups in the time it took for the specimens to reach the pathological results (P < 0.05).

Breast marking clip placement may be of some value in improving the X-ray evaluation of neoadjuvant chemotherapy for breast cancer and shortening the time of pathological diagnosis.