Home    中文  
 
  • Search
  • lucene Search
  • Citation
  • Fig/Tab
  • Adv Search
Just Accepted  |  Current Issue  |  Archive  |  Featured Articles  |  Most Read  |  Most Download  |  Most Cited

Chinese Journal of Interventional Radiology(Electronic Edition) ›› 2024, Vol. 12 ›› Issue (02): 114-119. doi: 10.3877/cma.j.issn.2095-5782.2024.02.003

• Basic Science Research • Previous Articles    

Skeletonized diffusion indexes identify age-related microstructural alteration in mouse brain

Jianyu Yuan1, Mingyao Liang1, Yi He1,(), Hong Shan1,()   

  1. 1. Molecular Imaging Center, the Fifth Affiliated Hospital Sun Yat-sen University; Guangdong Provincial Molecular Imaging Engineering Technology Research Center; Guangdong-Hong Kong-Macao University Joint Laboratory of Interventional Medicine, the Fifth Affiliated Hospital of Sun Yat-sen University, Guangdong Zhuhai 519000, China
  • Received:2024-04-10 Online:2024-05-25 Published:2024-06-11
  • Contact: Yi He, Hong Shan

Abstract:

Objective

To investigate the sensitivity of skeletonized diffusion indexes in detecting age-related microstructural alteration in the mouse brain and to evaluate the neurostructural plasticity of mouse brain from sexual to body maturity.

Methods

Diffusion tensor imaging (DTI) was used to scan 8-week-old and 12-week-old mice. White matter skeleton was analyzed by tract tracing-based spatial statistics (TBSS) based on advanced normalization tools (ANTs). The peak width of the skeletonized average diffusivity (PSMD) was used to assess age-related white matter microstructural characteristics in mice.

Results

In mature mice, numerous white matter fiber tracts, including the anterior commissure, as well as the anterior and genu of the corpus callosum, exhibited significantly higher fractional isotropy (FA) compared to those in sexually mature mice(P < 0.05). Conversely, within the middle of the body of the corpus callosum and the cingulate cortex, a notable reduction in FA was observed in mature mice (P < 0.05). Furthermore, the peak width of skeletonized mean diffusivity (PSMD) demonstrated a consistent increase in body mature mice (P < 0.001).

Conclusion

The skeletonized diffusion index can identify age-dependent microstructural changes in the mouse brain, suggesting that myelination of white matter tracts and further maturation of nerve fibers occur from sexual to full body maturity.

Key words: Diffusion tensor imaging (DTI), Tract-based spatial statistics (TBSS), Peak width of skeletonized mean diffusivity (PSMD)

京ICP 备07035254号-20
Copyright © Chinese Journal of Interventional Radiology(Electronic Edition), All Rights Reserved.
Tel: 0756-2528259 E-mail: zhjrfsx@163.com
Powered by Beijing Magtech Co. Ltd