To explore the effect of gradient compression stockings (GCS) combined with intermittent pneumatic compression (IPC) in the prevention of lower extremity deep vein thrombosis (LEDVT) in elderly patients with corona virus disease 2019 (COVID-19).

Sixty elderly patients with COVID-19 in our hospital from November 2022 to January 2023 were selected and randomly divided into observation group and control group through an online random number generator, with 30 cases in each group. The control group was given routine preventive intervention, while the observation group was given GCS combined with IPC inflation and compression intervention on the basis of routine intervention. The activated partial thromboplastin time (APTT), thrombin time (TT), bilateral femoral vein blood flow velocity, serum tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), patient satisfaction, occurrence rate of lower limb edema, and incidence rate of LEDVT were compared between the two groups.

There was no statistically significant difference in general data between the two groups of patients (P > 0.05). APTT, TT and bilateral femoral vein blood flow velocity in observation group were higher than those in control group, with statistically significant difference (P < 0.05). The incidence of lower limb swelling and LEDVT, TNF-α and IL-6 levels observation group were lower than those in control group (P < 0.05). The satisfaction of patients in observation group was significantly higher than that in control group (P < 0.05).

GCS combined with IPC can improve the coagulation function of elderly patients with COVID-19, reduce inflammatory reaction, increase the blood flow velocity of bilateral femoral veins, and significantly reduce the incidence of LEDVT.