Research progress of carotid atherosclerotic stenosis rabbit model for interventional therapy

doi:10.3877/cma.j.issn.2095-5782.2023.04.012

Abstract

Abstract:

Cerebral atherosclerotic stenosis is an important etiology for cerebrovascular diseases. In recent years, researchers are constantly exploring animal models that can simulate the human cerebral atherosclerosis process, to verify the therapeutic effect of the cerebral atherosclerosis stenosis treatments. This article reviewed the modeling methods of rabbit carotid atherosclerotic stenosis model, and give comments on the advantages and disadvantages of the commonly used modeling methods for rabbit carotid atherosclerotic stenosis models. Provides suggestions for the establishment of rabbit carotid atherosclerosis stenosis model suitable for interventional angioplasty study.

Key words: Carotid atherosclerotic stenosis, Rabbit, Animal model, Interventional therapy

Shikai Li, Jia Liang, Yanyan He, Yi Yu, Tianxiao Li, Jinlong Chang, Yingkun He. Research progress of carotid atherosclerotic stenosis rabbit model for interventional therapy[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2023, 11(04): 357-362.

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References 50

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球囊直径(mm)	球囊压力	术前高脂时间(周）	术后高脂时间(周)	损伤方式	血管病变状态	观察到出现≥50%狭窄率的时间(周)	文献
0.67	轻轻扩张	1	12	牵拉3次	有血管闭塞	13	[20]
1.00	扩为2.5 mm	2	18	2 cm/s抽拉3次	有血管闭塞	14	[23]
1.00	3 atm	-	10	旋转抽拉3次	中重度狭窄	10	[18]
1.50	8 atm	-	-	抽拉3次	轻度狭窄	无	[19]
2.00	8 atm	-	-	抽拉3次	轻度狭窄	无	[19]
2.50	12 atm	0	12	扩张30 s损伤	偏心性轻度狭窄	无	[22]
2.50	2 atm	1	7	抽拉3次	中重度狭窄	8	[21]
2.75	2 atm	1	7	抽拉3次	中重度狭窄	8	[21]
3.00	2 atm	1	7	抽拉	中重度狭窄	8	[21]

球囊直径(mm)	球囊压力	术前高脂时间(周）	术后高脂时间(周)	损伤方式	血管病变状态	观察到出现≥50%狭窄率的时间(周)	文献
0.67	轻轻扩张	1	12	牵拉3次	有血管闭塞	13	[20]
1.00	扩为2.5 mm	2	18	2 cm/s抽拉3次	有血管闭塞	14	[23]
1.00	3 atm	-	10	旋转抽拉3次	中重度狭窄	10	[18]
1.50	8 atm	-	-	抽拉3次	轻度狭窄	无	[19]
2.00	8 atm	-	-	抽拉3次	轻度狭窄	无	[19]
2.50	12 atm	0	12	扩张30 s损伤	偏心性轻度狭窄	无	[22]
2.50	2 atm	1	7	抽拉3次	中重度狭窄	8	[21]
2.75	2 atm	1	7	抽拉3次	中重度狭窄	8	[21]
3.00	2 atm	1	7	抽拉	中重度狭窄	8	[21]

流速(mL/min）	损伤时间(min)	术前高脂时间(周）	术后高脂时间(周)	血管病变状态	观察到出现≥50%狭窄率的时间(周)	文献
120	10	1	5	轻度狭窄	无	[29]
120	15	1	11	中重度狭窄	4	[26]
125	10	1	7	中重度狭窄	4	[30]
160	15	-	-	中重度狭窄	8	[27]
250	5	-	-	轻度狭窄	无	[25]
250	5	1	12	有血管闭塞	4	[28]

流速(mL/min）	损伤时间(min)	术前高脂时间(周）	术后高脂时间(周)	血管病变状态	观察到出现≥50%狭窄率的时间(周)	文献
120	10	1	5	轻度狭窄	无	[29]
120	15	1	11	中重度狭窄	4	[26]
125	10	1	7	中重度狭窄	4	[30]
160	15	-	-	中重度狭窄	8	[27]
250	5	-	-	轻度狭窄	无	[25]
250	5	1	12	有血管闭塞	4	[28]

刺激物	损伤时间	术前高脂时间(周)	术后高脂时间(周)	损伤部位	血管病变状态	观察到出现≥50%狭窄率的时间(周)	文献
0.5 mL液氮	2 min	-	8	血管内	斑块破裂	无	[32]
0.5 mL液氮	2 min	-	8	血管表面	斑块破裂	无	[33]
液氮气体	15 s	-		血管内	轻度狭窄	无	[37]
液氮气体	15 s	-	13	血管内	中重度狭窄	13	[37]
0.5 mL双氧水	-	1	11	血管内	中重度狭窄	8	[35]
无水乙醇	10 s	4	8	血管内	中重度狭窄	12	[36]
无水乙醇	15 s	4	8	血管内	有血管闭塞	12	[36]
1.2 mA电流	15 min	-	6	血管表面	轻度狭窄	无	[34]
5% FeCl₃溶液	5 min	1	11	血管表面	偏心性狭窄	8	[38]

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