Advances in preclinical application of magnetic particle imaging

doi:10.3877/cma.j.issn.2095-5782.2020.01.015

Abstract

Abstract:

Magnetic Particle Imaging (MPI) is a new generation of molecular imaging technology derived from Magnetic Resonance Imaging (MRI).It adopted complex combinations of rotary variable gradient magnetic field that can directly detect the Superparamagnetic Iron Oxide nanoparticles (SPIO) in vivo with high sensitivity of the Moore level. MPI is characterized by high temporal spatial resolution, high sensitivity, no scanning depth limitation and no ionizing radiation, etc. It has been applied in cell tracer,angiography,tumor imaging and treatment and other preclinical fields. Since its emergence in 2005, MPI has developed rapidly in software algorithms, hardware development, tracer design, and preclinical applications. Therefore, on the basis of briefly describing the history and basic principles of MPI, this article would summarize the research progress of MPI in cell tracer, blood vessel, tumor and other preclinical fields in recent years, and prospect the clinical transformation of MPI.

Key words: Magnetic particle imaging, Superparamagnetic iron oxide nanoparticles, Molecular imaging, Tracer

Dejing Zhang, Yong Li, Meixiao Zhan, Yongjie Xin, Wei Zhao, Ligong Lu. Advances in preclinical application of magnetic particle imaging[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2020, 08(01): 77-82.

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References 41

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成像模式	空间分辨率	成像速度	敏感度	主要细胞示踪剂
光学成像	20 μm/成像深度受限	秒级	μmol	荧光颜料（ICG，Cy，Luciferase等）
PET/SPECT	1 000～2 000 μm	分级	pmol	放射性核（In111，Tc99m，18 F，68 Ga等）
MRI	25～500 μm	分级	mmol	增强剂（钆，锰，SPIO，19 F等）
MPI	250～1 400 μm	秒级	0.1 μmol	SPIO

成像模式	空间分辨率	成像速度	敏感度	主要细胞示踪剂
光学成像	20 μm/成像深度受限	秒级	μmol	荧光颜料（ICG，Cy，Luciferase等）
PET/SPECT	1 000～2 000 μm	分级	pmol	放射性核（In111，Tc99m，18 F，68 Ga等）
MRI	25～500 μm	分级	mmol	增强剂（钆，锰，SPIO，19 F等）
MPI	250～1 400 μm	秒级	0.1 μmol	SPIO

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