Study on the best diagnostic value of D-dimer in perioperative venous thromboembolism of lung cancer

doi:10.3877/cma.j.issn.2095-5782.2019.04.004

Abstract

Abstract:

Objective:

To investigate the best diagnostic value of plasma D-dimer in the diagnosis of venous thromboembolism in patients with lung cancer during perioperative period.

Methods:

A total of 50 patients with lung cancer diagnosed as "lung cancer" by pathology and treated with standard radical resection of lung cancer. Perform Pulmonary artery CTA and deep vein ultrasonography of both lower extremities, monitor the dynamic changes of D-dimer during perioperative period. Compare The levels of D-dimer in patients with and without venous thromboembolism during perioperative period of lung cancer. Calculate the best diagnostic value through the receiver operating characteristic curve (ROC) .

Results:

A total of 50 patients with lung cancer were enrolled in this study. The incidence of VTE was 10% (5/50) , of which DVT was 10% (5/50) and PE was 2% (1/50) . And one patient occurred DVT and PE simultaneity, the patient recovered well after inferior vena cava filter (IVCF) implantation and anticoagulation therapy. The D-dimer level in the VTE group was significantly higher than that in the non-VTE group at 1st, 3rd, 5th and 7th day after operation (P<0.05) .

Conclusions:

D-dimer 2.79 mg/L is the best diagnostic value of venous thromboembolism in patients with lung cancer during perioperative period. It is helpful for early diagnosis, prevention and treatment of VTE, and has important significance for improving the prognosis of VTE patients.

Key words: D-dimer, Lung cancer, Perioperative, Venous thromboembolism

Wen Chen, Changming Nong, Yi Feng, Guixiong Zheng, Yan Liang, Xingqiang Cen, Junyuan Zhang, Hong Zhong. Study on the best diagnostic value of D-dimer in perioperative venous thromboembolism of lung cancer[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2019, 07(04): 283-286.

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References 10

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组别	例数	术前	术后1 d	术后3 d	术后5 d	术后7 d
非VTE组	45	0.91±1.79	1.74±1.61	3.72±2.91	2.96±2.49	2.16±1.56
VTE组	5	0.62±0.41	6.06±5.05	6.76±5.3	7.12±5.26	4.73±3.88
t值	?	0.358	4.321	2.027	3.122	2.924
P值	?	0.722	<0.001	0.048	0.003	0.005

组别	例数	术前	术后1 d	术后3 d	术后5 d	术后7 d
非VTE组	45	0.91±1.79	1.74±1.61	3.72±2.91	2.96±2.49	2.16±1.56
VTE组	5	0.62±0.41	6.06±5.05	6.76±5.3	7.12±5.26	4.73±3.88
t值	?	0.358	4.321	2.027	3.122	2.924
P值	?	0.722	<0.001	0.048	0.003	0.005

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