Efficacy of endovascular embolization using combination of Embosphere microspheres and mechanical coils in treatment of massive hemoptysis

doi:10.3877/cma.j.issn.2095-5782.2017.04.014

Abstract

Abstract:

Objective:

To evaluate the clinical efficacy of bronchial artery embolization (BAE) using combination of Embosphere microspheres and mechanical coils in treatment of massive hemoptysis.

Methods:

During the period from October 2014 to January 2016, a total of 52 patients with massive hemoptysis who had failed to respond to medical management received BAE, among these, the clinical efficacy of massive hemoptysis patients treated with Embosphere microspheres (n=25, group EM) was compared with those treated with combination of Embosphere microspheres and mechanical coils (n=27, group MC) . All patients were followed up for 1 year.

Results:

BAE was successfully accomplished in all 52 patients with an effective rate of 96.15% for bleeding-cessation within 24 h. In each group there was 1 case of hemoptysis, without statistical significance (P>0.05) . Recurrence of hemoptysis within 1 year after BAE was seen in 9 patients (nEM=7, nMC=2, 8/52, 17.31%) . Recurrence of hemoptysis within 3 months after BAE was found in 1 patient in both EM and MC groups (P>0.05) . MC group had a lower recurrence rate than EM group during the follow-up period of 3~12 months after the procedure (3.7% vs 24%, P<0.05) .

Conclusions:

Combination of Embosphere microspheres and mechanical coils can efficient improve the metaphase and long-term efficacy of BAE, and reduce the recurrence of hemoptysis.

Key words: Embosphere microspheres, Mechanical coils, Combined embolization, Bronchial artery embolization, Efficacy

Changsheng Shi, Qing Yang, Cheng Li, Xixiang Yu, Zhenjing Shi, Bingru Zheng. Efficacy of endovascular embolization using combination of Embosphere microspheres and mechanical coils in treatment of massive hemoptysis[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2017, 05(04): 269-272.

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References 14

1	Rémy J, Arnaud A, Fardou H, et al. Treatment of hemoptysis by embolization of bronchial arteries 1[J]. Radiology, 1977, 122(1): 33-37.
2	Tom LM, Palevsky HI, Holsclaw DS, et al. Recurrent bleeding, survival, and longitudinal pulmonary function following bronchial artery embolization for hemoptysis in a U. S. adult population[J]. J Vasc Interv Radiol, 2015, 26(12): 1806-1813. doi: 10.1016/j.jvir.2015.08.019.
3	李成，施昌盛，虞希祥，等. Embosphere微球靶血管栓塞治疗中晚期肺癌大咯血的疗效[J/CD].中华介入放射学电子杂志，2016，4(3):155-157. doi:10.3877/cma.j.issn.2095-5782.2016.03.007.
4	李建军，翟仁友，戴定可，等.支气管动脉栓塞术治疗咯血的疗效分析[J].介入放射学杂志，2007，16(1):21-23. doi: 10.3969/j.issn.1008-794X.2007.01.006.
5	Bhalla A, Kandasamy D, Veedu P, et al. A retrospective analysis of 334 cases of hemoptysis treated by bronchial artery embolization[J]. J Vasc Interv Radiol, 2014, 25(3):S156-S157.
6	王草叶，王祁，何忠明，等.PVA颗粒联合金属弹簧圈栓塞治疗支气管扩张咯血临床价值分析[J].医学影像学杂志,2013,23(11):1699-1702.
7	吕洋，谭玉林.支气管动脉栓塞术治疗29例大咯血的临床分析[J].中华全科医学,2014,12(12):1929-1931.
8	施昌盛，虞希祥，施振静,等.应用Embosphere微球栓塞治疗难治性鼻出血[J].介入放射学杂志, 2012, 21(08):672-674.
9	Kim SW, Lee SJ, Ryu YJ, et al. Prognosis and predictors of rebleeding after bronchial artery embolization in patients with active or inactive pulmonary tuberculosis[J]. Lung, 2015,193(4):575-581. doi: 10.1007/s00408-015-9728-4.
10	Fruchter O, Schneer S, Rusanov V, et al. Bronchial artery embolization for massive hemoptysis: long-term follow-up.[J]. Asian Cardiovasc Thorac Ann，2015，23(1):55-60. doi: 10.1177/0218492314544310.
11	Ittrich H, Klose H, Adam G, et al. Radiologic management of haemoptysis: diagnostic and interventional bronchial arterial embolisation[J]. Rofo, 2015, 187:248-259.
12	苏旭东，于世平，苏秀琴,等.支气管动脉栓塞治疗咯血后复发原因分析及预防措施[J].当代医学,2012,18(6):31-34.doi:10.3969/j.issn.1009-4393.2012.6.010.
13	Shao H, Wu J, Wu Q, et al. Bronchial artery embolization for hemoptysis: a retrospective observational study of 344 patients[J]. Chin Med J（Engl）, 2015, 128(1): 58-62. doi: 10.4103/0366-6999.147811.
14	Robbins IM, Johnson J, Petracek M, et al. Translocation of microspheres into the pulmonary artery after bronchial artery injection[J]. Am J Respir Crit Care Med, 2015,191(12):e28-29. doi: 10.1164/rccm.201412-2325IM.

组别	例数	性别（男/女）	年龄（岁）	病因（例）
组别	例数	性别（男/女）	年龄（岁）	肺结核	支气管扩张	肺癌	血管畸形	不明原因
EM组	25	13/12	65.5±9.3	10	11	1	0	3
MC组	27	16/11	67.5±6.0	6	15	2	3	1
统计量	?	χ²=2.920	t=1.303	χ²=2.032	χ²=3.747	χ²=2.441	χ²=2.728	χ²=1.691
P值	?	0.60	0.17	0.17	0.41	1.0	0.24	0.34

组别	例数	性别（男/女）	年龄（岁）	病因（例）
组别	例数	性别（男/女）	年龄（岁）	肺结核	支气管扩张	肺癌	血管畸形	不明原因
EM组	25	13/12	65.5±9.3	10	11	1	0	3
MC组	27	16/11	67.5±6.0	6	15	2	3	1
统计量	?	χ²=2.920	t=1.303	χ²=2.032	χ²=3.747	χ²=2.441	χ²=2.728	χ²=1.691
P值	?	0.60	0.17	0.17	0.41	1.0	0.24	0.34

组别	例数	3个月内	3～12个月
EM组	25	1(4.0)	6(24)
MC组	27	1(3.7)	1(3.7)
χ²值	?	3.003	6.094
P值	?	>0.05	<0.05

组别	例数	3个月内	3～12个月
EM组	25	1(4.0)	6(24)
MC组	27	1(3.7)	1(3.7)
χ²值	?	3.003	6.094
P值	?	>0.05	<0.05

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