Preliminary investigation of PET-CT applied in malignant maxillary cancer patients undergoing radioactive seeds implantation

doi:10.3877/cma.j.issn.2095-5782.2016.03.004

Abstract

Abstract:

Objective:

To investigate the value of PET-CT guided target localization technique in radioactive iodine 125 seeds implantation for treating malignant maxillary cancer.

Methods:

Eleven patients diagnosed with maxillary malignant tumors underwent PET-CT scans and CT scans. The three-dimensional tumor imaging generated data was converted into DICOM format by the treatment planning system. Virtual implantation was also manipulated according to the three-dimensional position of the tumor. Gross tumor volume and matched peripheral dose were compared in different imaging methods.

Results:

The volumes of BTV and GTV by PET-CT were (35.21±7.8) cm³ and (42.17±9.32) cm³, respectively. Compared to CT imaging, the volumes and dose were significantly smaller (t=7.25, P<0.05). No tumors recurred and there were no severe complications.

Conclusions:

PET-CT is a feasible and reliable method for the diagnosis and treatment of maxillary malignant tumor, and it can significantly improve the accuracy of iodine 125 seeds implantation.

Key words: Maxillary neoplasms, Positron-emission tomography, Brachytherapy, Iodine 125 seeds implantation, Treatment plan system

Xing Wang, Jian Meng, Qianping Gu, Jie Zhang. Preliminary investigation of PET-CT applied in malignant maxillary cancer patients undergoing radioactive seeds implantation[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2016, 04(03): 142-145.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhjrfsxdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-5782.2016.03.004

https://zhjrfsxdzzz.cma-cmc.com.cn/EN/Y2016/V04/I03/142

Figures/Tables 3

References 15

1	王兴, 孟箭. ¹²⁵I植入联合尼妥珠单抗治疗头颈部恶性肿瘤的近期疗效及安全性评价[J]. 中华临床医师杂志:电子版, 2013,7(13): 6152-6154. doi：10.3969/cma.j.issn.1674-0785.2013.13.141.
2	Meng J, Meng QF, Gu QP, et al. Radioactive seed implantation combined with prosthesis denture in treatment of oral and maxillofacial malignancy[J]. Cell Biochem Biophys, 2013,67(3):1529-1532. doi: 10.1007/s12013-013-9656-y.
3	李锐, 付坤, 高宁, 等. MRI导航下125I治疗颌面部腺源性恶性肿瘤效果初探[J]. 中华口腔医学杂志, 2016,51(6): 346-349. doi:10.3760/cma.j.issn.1002-0098.2016.06.006.
4	Jiang YL, Meng N, Wang JJ, et al. Percutaneous computed tomography/ ultrasonography-guided permanent iodine-125 implantation as salvage therapy for recurrent squamous cell cancers of head and neck[J]. Cancer Biol Ther, 2010,9(12): 959-966.
5	马一栋, 胡漫, 卢洁, 等. 双示踪剂PET-CT在头颈部肿瘤生物适形调强放疗的初步研究[J]. 中华放射医学与防护杂志, 2014,34(8): 601-605. doi:10.3760/cma.j.issn.0254-5098.2014.08.010.
6	Han DL, Yu JM, Yu YH, et al. Comparison of 18F-fluorothymidine and 18F-fluorodeoxyglucose PET/CT in delineating gross tumor volume by optimal threshold in patients with squamous cell carcinoma of thoracic esophagus[J]. Int J Radiat Oncol Biol Phys, 2010,76(4):1235-1241. doi: 10.1016/j.ijrobp.2009.07.1681.
7	Looser KG, Shah JP, Strong EW. The significance of "positive" margins surgically resected epidermoid carcinomas[J]. Head Neck Surg, 1978,1(2):107-111.
8	Khalilur R, Hayashi K, Shibuya H. Brachytherapy for tongue cancer in the very elderly is an alternative to external beamradiation[J]. Br J Radiol, 2011, 84(1004): 747-749. doi: 10.1259/bjr/23130739.
9	王俊杰, 修典荣, 冉维强. 放射性粒子组织间近距离治疗肿瘤[M]. 2版. 北京大学医学出版社, 2004: 26-61.
10	Jiang P, Jiang Y, Wang JJ, et al. Percutaneous ultrasonography-guided permanent iodine-125 implantation as salvage therapy for recurrent head and neck carcinomas[J]. Cancer Biother Radiopharm，2011，26(6):753-757. doi: 10.1089/cbr.2010.0844.
11	张杰, 张建国, 朱铁砾, 等. 经CT引导头颈部恶性肿瘤¹²⁵I放射性粒子的植入[J]. 华西口腔医学杂志, 2008, 26(1): 8-14. doi:10.3321/j.issn:1000-1182.2008.01.003.
12	王璟媛, 张春明, 高伟, 等. PET-CT和SPECT-CT联合在评估颈部淋巴结转移阴性喉鳞癌患者前哨淋巴结微转移中的临床价值[J].中华临床医师杂志:电子版, 2014,8(12):2204-2209. doi：10.3877/cma.j.issn.1674-0785.2014.12.005.
13	王兴, 孟箭, 李志萍, 等. ¹²⁵I粒子植入治疗高龄非霍奇金淋巴瘤并吞咽困难一例[J]. 中华全科医师杂志, 2015,14(5):388-389. doi：10.3877/cma.j.issn.2095-5782.2016.03.002.
14	Meng J, Zhang J, Zhuang Q, et al. TPS-guided interstitial Iodine-125 implantation in patients with oral cavity and maxillofacial carcinomas[J]. Eur Rev Med Pharmacol Sci, 2014,14(2): 2803-2807.
15	霍小东, 柴树德, 郑广均, 等. PET-CT在¹²⁵I放射性粒子植入治疗肺癌中的作用[J]. 中国临床医学影像杂志, 2011,22(9): 616-618. doi：10.3969/j.issn.1008-1062.2011.09.003.

序号	年龄(岁)	性别	肿瘤部位	病理类型	TNM分期	SUVmax
1	22	女	软硬腭	腺样囊性癌	T_4aN₀M₀	7.8
2	53	女	软硬腭	腺样囊性癌	T_4bN₀M₀	4.7
3	47	女	软硬腭	腺样囊性癌	T_4aN₀M₀	6.3
4	62	女	上颌窦	中分化鳞癌	T_4aN₁M₀	4.4
5	66	男	软硬腭	腺样囊性癌	T_4bN₀M₀	3.9
6	53	男	硬腭	低分化黏液表皮样癌	T_4aN₀M₀	9.3
7	55	女	软硬腭	腺样囊性癌	T_4bN₀M₀	3.8
8	81	女	上颌窦	肌上皮癌	T_4bN₀M₀	8.8
9	28	女	软硬腭	腺样囊性癌	T_4aN₀M₀	7.9
10	44	男	上颌窦	腺样囊性癌	T_4bN₀M₀	6.5
11	31	男	硬腭	腺样囊性癌	T_4aN₀M₀	8.5

序号	年龄(岁)	性别	肿瘤部位	病理类型	TNM分期	SUVmax
1	22	女	软硬腭	腺样囊性癌	T_4aN₀M₀	7.8
2	53	女	软硬腭	腺样囊性癌	T_4bN₀M₀	4.7
3	47	女	软硬腭	腺样囊性癌	T_4aN₀M₀	6.3
4	62	女	上颌窦	中分化鳞癌	T_4aN₁M₀	4.4
5	66	男	软硬腭	腺样囊性癌	T_4bN₀M₀	3.9
6	53	男	硬腭	低分化黏液表皮样癌	T_4aN₀M₀	9.3
7	55	女	软硬腭	腺样囊性癌	T_4bN₀M₀	3.8
8	81	女	上颌窦	肌上皮癌	T_4bN₀M₀	8.8
9	28	女	软硬腭	腺样囊性癌	T_4aN₀M₀	7.9
10	44	男	上颌窦	腺样囊性癌	T_4bN₀M₀	6.5
11	31	男	硬腭	腺样囊性癌	T_4aN₀M₀	8.5

[1]	Siyun Du, Ping Fu, Baodong Gai, Dongyan Yang. Ultrasound-guided interstitial implantation of iodine-125 seeds for treatment of malignant abdominal tumors [J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2019, 16(02): 142-146.
[2]	Tingting He, Yankun Shi, Kehui Yuan, Rongrong Hu, Jiangshan Huang, Liang Chen, Ruimin Wang. Diagnostic value of ¹⁸F-FDG PET/CT imaging in breast imaging reporting and data system ultrasound category 3-5 lesions [J]. Chinese Journal of Breast Disease(Electronic Edition), 2021, 15(01): 4-10.
[3]	Shuang Dong, Xiaoying Li, Litao Sun, Jiawei Tian. Advances in the application of imaging techniques in preoperative staging of cervical cancer [J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(01): 113-119.
[4]	Zhiyong Mei, Qing Pang, Yong Wang, Zhongran Man, Hao Jin, Huichun Liu. Comparison of the efficacy between stent combined with ¹²⁵I seeds intracavitary irradiation and palliative surgery in advanced extrahepatic cholangiocarcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2021, 15(06): 412-417.
[5]	Zhengyang Yang, Song Liu, Shichao Ai, Wenxian Guan. Status and progress of new PET-CT probe application in gastric cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2019, 13(02): 209-214.
[6]	Jiahui Zhao, Zhu Hou, Yong Luo, Mingchuan Li, Tao Peng, Yongxing Wang, Yongguang Jiang. Clinical analysis of urinary complications of brachytherapy in patients of prostate cancer [J]. Chinese Journal of Endourology(Electronic Edition), 2022, 16(05): 400-403.
[7]	Xi Zhang, Xianli Qin, haijie Fu, Jingna Zhang, Ye Zhang, Yifei Han. Pulmonary sclerosing pneumocytoma of the lung: MSCT and ¹⁸F-FDG PET/CT imaging characteristics [J]. Chinese Journal of Lung Diseases(Electronic Edition), 2022, 15(03): 300-305.
[8]	Zidong Zhou, Yueming Zha, Wenshan Huang, Min Yang, Guixiong Zhang, Jiehua Xu. Differential diagnosis of moderately- or poorly-differentiated hepatocellular carcinoma from intrahepatic cholangiocarcinoma based on ¹⁸F-FDG PET-CT radiomics features [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2019, 08(02): 154-158.
[9]	Xin Zhang, Jiaxin Xie, Yaping Feng. Application of multimodality imaging in the diagnosis and treatment of spinal cord injury [J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2020, 06(05): 312-316.
[10]	Xinfeng Lin, Nan Li, Fei Wang, Wei Zhao, Zhi Yang. Clinical value of ¹⁸F-FDG PET/CT in postoperative colorectal cancer patients with elevated serum carcinoembryonic antigen [J]. Chinese Journal of Clinicians(Electronic Edition), 2019, 13(11): 822-827.
[11]	Xing Wang, Qingfei Meng, Cuiling Shao, Yuting Bai, Jian Meng. Application of prosthesis assisting postoperative brachytherapy for jaw bone neoplasms [J]. Chinese Journal of Clinicians(Electronic Edition), 2018, 12(10): 563-566.
[12]	Gang Li, Quanyi Wang, Jinwang Su, Jie Ding, Peng Gao, Xuebo Chen. Short term effect of new double ¹²⁵I chain biliary drainage tube for the treatment of cholangiocarcinoma with jaundice (report of 9 cases) [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2021, 09(04): 403-406.
[13]	Yujing Xin, Yi Chen, Yanan Wang, Yi Yang, Xiang Zhou. Clinical analysis of ultrasound-guided celiac ganglion irradiation with ¹²⁵I seeds for pain control in local advanced pancreatic carcinoma [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2020, 08(01): 38-43.
[14]	Hongtao Zhang, Xiaoli Liu, Ruming Zhou, Huimin Yu, Aixia Sui, Yanzhu Bian, Juan Wang, Gaofeng Shi. Evaluating dose distribution and therapeutic effect of prostate cancer brachytherapy with gamma-ray detecting by SPECT/CT [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2019, 07(04): 278-282.
[15]	Jianjian Chen, Yuan Yao, Xueliang Zhou, Dechao Jiao, Xinwei Han. Current status and research progress of metal stent combined with intraluminal antineoplastic technique in treatment of malignant biliary obstruction [J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2019, 07(02): 163-167.

Please choose a citation manager

Content to export